A Novel Crystal Form of Cabergoline, Form L

Ham, Zoran; Svete, Peter; Urleb, Uroš; Kocjan, Darko
September 2011
Acta Chimica Slovenica;2011, Vol. 58 Issue 3, p492
Academic Journal
A new crystal form of cabergoline, form L, was discovered and characterized by thermal analyses, X-ray powder diffraction (XRPD), infrared spectroscopy (IR), Raman spectroscopy, dynamic vapor sorption (DVS), and comparative dissolution behavior. The morphology of rod-shaped crystals was investigated by scanning electron microscopy (SEM). Form L was compared to other non-solvated forms of cabergoline such as form I, II, VII and to the amorphous form. The thermodynamic stability of form L is supported by its long-term stability. Form L is a pharmaceutically applicable crystal form.


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