TITLE

Contemporary genetic technologies and female reproduction

PUB. DATE
November 2011
SOURCE
Human Reproduction Update;Nov2011, Vol. 17 Issue 6, p829
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
BACKGROUND The Fifth Evian Annual Reproduction (EVAR) Workshop Meeting discussed knowledge regarding contemporary genetics in female reproduction. METHODS Specialist reproductive medicine clinicians and geneticists delivered presentations based on published literature and current research. The content of this report is based on the expert presentations and subsequent group discussions that took place during this Workshop. RESULTS Numerous ovarian genes with a role in infertility have been identified. Future challenges for genetic screening of patients, such as those with polycystic ovary syndrome, primary ovarian insufficiency or endometriosis, include the identification of high-throughput strategies and how to apply these findings to infertile patients. The identification of high-quality embryos in IVF using objective technologies remains a high priority in order to facilitate single-embryo transfer. Gene expression profiling of cumulus cells surrounding the oocyte, and proteomic and metabolomic approaches in embryo culture media may significantly improve non-invasive embryo quality assessment. CONCLUSIONS The way forward in advancing the knowledge of genes involved in reproduction was considered to be through genome-wide association studies involving large numbers of patients. Establishing international collaboration is required to enable the application of such technologies in sufficient numbers of patients.
ACCESSION #
66733930

 

Related Articles

  • Can proteomics help to shape the future of human assisted conception? Katz-Jaffe, M. G.; Gardner, D. K. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Oct2008, Vol. 17 Issue 4, p497 

    Proteomics describes the changes in all proteins expressed and translated from a single genome. At present little is known regarding either the genome or proteome of human gametes or the preimplantation embryo. The unravelling of this information is fundamental to understanding the complexity of...

  • Number and Size of Antral Follicles as Predictive Factors in Vitro Fertilization and Embryo... Pohl, Michaela; Hohlagschwandtner, Maria // Journal of Assisted Reproduction & Genetics;Jul2000, Vol. 17 Issue 6, p315 

    Evaluates whether number and size of antral follicles can predict the outcome of in vitro-fertilization-embryo transfer. Use of three-dimensional transvaginal ultrasound technology; Application of gonadotropin; Implantation rate, number of retrieved oocytes and endometrium thickness.

  • Number and Size of Antral Follicles as Predictive Factors in Vitro Fertilization and Embryo... Pohl, Michaela; Hohlagschwandtner, Maria // Journal of Assisted Reproduction & Genetics;Jul2000, Vol. 17 Issue 6, p315 

    Evaluates whether number and size of antral follicles can predict the outcome of in vitro-fertilization-embryo transfer. Use of three-dimensional transvaginal ultrasound technology; Application of gonadotropin; Implantation rate, number of retrieved oocytes and endometrium thickness.

  • Implicación clínica y frecuencia del hallazgo incidental de endometriosis durante la captura ovular. Anguas, Julián Ruiz; Mondragón, Esperanza Carballo; Jaen, Everardo Anta; Monterrosas, Leonor Durán; Ambe, Alberto Kably // Ginecologia y Obstetricia de Mexico;mar2007, Vol. 75 Issue 3, p121 

    Background: Endometriosis is a clinical disease that is associated with poor outcomes in in vitro fertilization (IVF) programs with a decrease in oocyte retrieval, oocyte quality, implantation and pregnancy rates. When an endometrioma is diagnosed, it is indicated to remove endometrial cysts by...

  • A NOVEL OPERATIVE TREATMENT OF SEVERE ADENOMYOSIS PRIOR TO EMBRYO TRANSFER. Osada, H. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Oct2010 S3 Supplemen, Vol. 20, pS14 

    Introduction: Severe case of adenomyosis is not only a cause of infertility, but may include severe dysmenorrhea, thus may interfere with a woman's well-being. Routine conservative surgery for adenomyosis involves a wedge resection of the involved uterine tissue, followed by approximating the...

  • Sensitivity of Women to Luteinizing Hormone.  // Fertility Weekly;6/23/2003, p7 

    Compares the sensitivity of the granula cells of women with endometriosis to luteinizing hormone (LH) with that of the cells of women without the condition. Impact of the disease on oocyte fertilization rates in vitro in women; Cycles stimulated with exogenous gonadotropins; Abnormalities of...

  • Cumulative impact of adding frozen--thawed cycles to single versus double fresh embryo transfers. Lundin, Kersti; Bergh, Christina // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Jul2007, Vol. 15 Issue 1, p76 

    Randomized control trials have shown that single embryo transfer (SET) results in lower live birth rates than double embryo transfer (DET), while observational, retrospective studies find no decrease in overall live birth rate when using a SET policy. The cumulative (fresh transfer followed by...

  • Women with the Disease Have Slightly Fewer Children than the General Population. Hansen, V. Hjordt // Fertility Weekly;8/18/2014, p10 

    The article discusses a study conducted in Denmark suggesting that women with endometriosis have slightly fewer numbers of children compared to those without the disease. It notes that the study was designed to evaluate long-term reproductive prognosis and all pregnancy outcomes for the disease...

  • Endometriosis, assisted reproduction technology, and risk of adverse pregnancy outcome. Stephansson, Olof; Kieler, Helle; Granath, Fredrik; Falconer, Henrik // Human Reproduction;Sep2009, Vol. 24 Issue 9, p2341 

    BACKGROUND: Endometriosis, a common gynaecological disease, is characterized by local and systemic inflammation, which may cause infertility and consequently, increased utilization of assisted reproduction technology (ART). We aimed to estimate the risk for preterm birth,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics