Myopathy with antibodies to the signal recognition particle: clinical and pathological features

Miller, T.; Al-Lozi, M. T.; Lopate, G.; Pestronk, A.
October 2002
Journal of Neurology, Neurosurgery & Psychiatry;Oct2002, p420
Academic Journal
No abstract available.


Related Articles

  • Azathioprine.  // Reactions Weekly;11/17/2012, Issue 1428, p9 

    The article describes the case of a pregnant woman who developed hepatotoxicity while receiving azathioprine for anti-signal recognition particle antibody-positive necrotising myopathy.

  • Clinical and histopathological features of myopathies in Japanese patients with anti-SRP autoantibodies. Takada, Tetsuya; Hirakata, Michito; Suwa, Akira; Kaneko, Yuko; Kuwana, Masataka; Ishihara, Tadayuki; Ikeda, Yasuo // Modern Rheumatology (Springer Science & Business Media B.V.);Apr2009, Vol. 19 Issue 2, p156 

    To elucidate the clinical and histopathological features associated with autoantibodies to the signal recognition particle (SRP), we have studied 23 Japanese patients with this specificity among 3,500 patients with polymyositis/dermatomyositis and other connective tissue diseases. Anti-SRP...

  • Unusual manifestations in two cases of necrotizing myopathy associated with SRP antibodies. Hanisch, F.; Müller, T.; Stoltenburg, G.; Zierz, S. // Rheumatology International;May2013, Vol. 33 Issue 5, p1371 

    A letter to the editor is presented which discusses two cases of necrotizing myopathy associated with signal recognition particle (SRP).

  • Myopathy and an unusual serum antibody point to a defined syndrome.  // Journal of Clinical Pathology;Jan2003, Vol. 56 Issue 1, p51 

    Cites key research findings on syndromes affecting skeletal muscles. Findings that patients found with serum antibody to the signal recognition particle represent a defined syndrome; Empirical evidence on improvements in muscle strength from early corticosteroid treatment; Implications on...

  • Inflammatory and Immune Myopathies: Concepts in Diagnosis and Treatment. Pestronk, Alan // Journal of Child Neurology;Mar2002, Vol. 17 Issue 3, p205 

    Discusses diagnosis and treatment of inflammatory and immune myopathies. Classification of myopathies; Clinical characteristics of polymyositis; Pathologic features of the anti-Jo-1 clinical syndrome.

  • Analysis on clinical features of necrotizing autoimmune myopathy. LI Yi; FU Jun; MENG Ling-chao; ZHANG Wei; WANG Zhao-xia; LÜ He; ZUO Yue-huan; YUAN Yun // Chinese Journal of Contemporary Neurology & Neurosurgery;Oct2016, Vol. 16 Issue 10, p689 

    Objective To investigate the clinical manifestations and auxiliary examination features of necrotizing autoimmune myopathy (NAM). Methods According to the inclusion criteria from European Neuromuscular Center (ENMC) International Workshop on idiopathic inflammatory myopathies published in 2004,...

  • Successful treatment of refractory anti-signal recognition particle myopathy using abatacept. Maeshima, Keisuke; Kiyonaga, Yasuhiro; Imada, Chiharu; Iwakura, Mikako; Hamasaki, Hajime; Haranaka, Miwa; Ishii, Koji // Rheumatology;Feb2014, Vol. 53 Issue 2, p379 

    A letter to the editor is presented which discussed a study on the efficacy of abatacept treatment in the remission of anti-signal recognition particle (SRP)- positive myopathy.

  • Serum levels of anti-SRP54 antibodies reflect disease activity of necrotizing myopathy in a child treated effectively with combinatorial methylprednisolone pulses and plasma exchanges followed by intravenous cyclophosphamide. Momomura, Mei; Miyamae, Takako; Nozawa, Tomo; Kikuchi, Masako; Kizawa, Toshitaka; Imagawa, Tomoyuki; Drouot, Laurent; Jouen, Fabienne; Boyer, Olivier; Yokota, Shumpei // Modern Rheumatology (Springer Science & Business Media B.V.);May2014, Vol. 24 Issue 3, p529 

    We describe the effectiveness of combinatorial therapy with plasma exchanges and methylprednisolone pulses followed by intravenous cyclophosphamide in a young girl with anti-signal recognition particle 54 (SRP54) antibody-associated myopathy. We also use a newly described quantitative assay to...

  • Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expression. Gunawardena, Harsha; Betteridge, Zoe E.; McHugh, Neil J. // Rheumatology;Jun2009, Vol. 48 Issue 6, p607 

    The idiopathic inflammatory myopathies (IIMs)—DM and PM—have been historically defined by broad clinical and pathological criteria. These conditions affect both adults and children with clinical features including muscle weakness, skin disease, internal organ...

  • Clinical utility of anti-signal recognition particle antibody in the differential diagnosis of myopathies. S. Suzuki; T. Satoh; S. Sato; M. Otomo; Y. Hirayama; H. Sato; M. Kawai; T. Ishihara; N. Suzuki; M. Kuwana // Rheumatology;Oct2008, Vol. 47 Issue 10, p1539 

    Objective. Auto-antibodies to signal recognition particle (SRP) are known to be specific to PM among rheumatic disorders, but the specificity in myopathic diseases remains unclear. The clinical utility of anti-SRP antibody in the differential diagnosis of myopathies has not been studied. The aim...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics