Corticosteroids in the Treatment of Alcohol-Induced Rhabdomyolysis

October 2011
Mayo Clinic Proceedings;Oct2011, Vol. 86 Issue 10, p1005
Academic Journal
Rhabdomyolysls is a common condition with potentially devastating complications, including acute renal failure, arrhythmias, and death. The standard of care Is to use supportive measures such as aggressive fluid repietion to prevent kidney Injury and attenuate clinical symptoms. Besides fluid management, few therapeutic options are available for the treatment of acute rhabdomyoiysls. As a resuit, acute and refractory cases remain difficult to manage. We report a case of alcohol-induced rhabdomyolysis that responded dramatlcaliy to high-dose corticosteroids. A 55-year-oid man presented to the emergency department for evaluation of dif- fuse muscle pain, weakness, and darkening urine. On admission, his creatlne kinase (CR) level was 50,022 U/L. Despite aggressive fluid repietion, his CR level continued to increase, peaking at 401,280 U/L with a concomitant Increase In muscle pain and urine darkening. On administration of high-dose cortlcosteroids, clinical symptoms and CK levels improved dramaticaliy, and the patient was discharged 36 hours later with complete resolution of muscle pain and weakness. Given their iow toxicity profile, short-term high-dose corticosterolds may be a vaild treatment option for recurrent rhabdomyolysis unresponsive to fluid repletion.


Related Articles

  • Acute swollen legs due to rhabdomyolysis: initial management as deep vein thrombosis may lead to acute renal failure. Mallinson, R.H.; Goldsmith, D.J.A.; Higgins, R.M.; Venning, M.C.; Ackrill, P. // BMJ: British Medical Journal (International Edition);11/19/94, Vol. 309 Issue 6965, p1361 

    Investigates the association of management of bilateral calf swelling caused by rhabdomyolysis with the development of acute renal failure. Characteristics of rhabdomyolysis; Diagnosis of the disease; Treatment of rhabdomyolysis.

  • Acute Renal Failure Due to Nontraumatic Rhabdomyolysis. Koffler, Alan; Friedler, Robert M.; Massry, Shaul G. // Annals of Internal Medicine;Jul76, Vol. 85 Issue 1, p23 

    Focuses on a study which examined acute renal failure caused by nontraumatic rhabdomyolysis. Association between the diseases; Materials and methodology; Results and discussion.

  • Propofol infusion syndrome in a super morbidly obese patient (BMI = 75). Ramaiah, Ramesh; Lollo, Loreto; Brannan, Douglas; Bhananker, Sanjay M. // International Journal of Critical Illness & Injury Science;Jan-Jun2011, Vol. 1 Issue 1, p84 

    Propofol infusion syndrome (PRIS) is a rare but often fatal complication as a result of large doses of propofol infusion (4–5 mg/kg/hr) for a prolonged period (>48 h). It has been reported in both children and adults. Besides large doses of propofol infusion, the risk factors include...

  • Rhabdomyolysis and acute renal failure in children. Watanabe, T. // Pediatric Nephrology;Dec2001, Vol. 16 Issue 12, p1072 

    Acute renal failure (ARF) is an important complication of rhabdomyolysis. However, the contributing factors to the development of ARF in children with rhabdomyolysis remain obscure. The aim of this study was to clarify the factors contributing to the development of ARF in children with...

  • Acute renal failure due to rhabdomyolysis in presence of concurrent ciprofibrate and ibuprofen...  // BMJ: British Medical Journal (International Edition);05/31/97, Vol. 314 Issue 7094, p1593 

    Presents an abstract of a study entitled `Acute Renal Failure Due to Rhabdomyolysis in Presence of Concurrent Ciprofibrate and Ibuprofen Treatment,' by S. Ramachandran, P.D. Giles et al.

  • Fenofibrate.  // Reactions Weekly;1/5/2008, Issue 1183, p15 

    The article describes the case of a 42-year-old woman who developed rhabdomyolysis and acute renal failure during treatment with fenofibrate. The patient was administered fenofibrate and candesartan cilexetil/hydrochlorothiazide for hypertension and hyperlipidaemia. She was later hospitalised...

  • Atorvastatin/nitrates interaction: Rhabdomyolysis and acute renal failure in an elderly patient: case report.  // Reactions Weekly;Dec2013, Issue 1481, p9 

    The article presents a case study of a 65-year-old woman who was diagnosed with rhabdomyolysis and acute renal failure while receiving atorvastatin and a nitrate drug for hyperlipidaemia and ischaemic heart disease.

  • Dengue-associated acute kidney injury. Oliveira, João Fernando Picollo; Burdmann, Emmanuel A. // Clinical Kidney Journal;Dec2015, Vol. 8 Issue 6, p681 

    Dengue is presently the most relevant viral infection transmitted by a mosquito bite that represents a major threat to public health worldwide. Acute kidney injury (AKI) is a serious and potentially lethal complication of this disease, and the actual incidence is unknown. In this review, we will...

  • Rhabdomyolysis and acute kidney injury in two children: Answers. Fidan, Kibriya; Kandur, Yasar; Tumer, Leyla; Hasanoglu, Alev; Soylemezoglu, Oguz // Pediatric Nephrology;Jun2013, Vol. 28 Issue 6, p901 

    Answers to a quiz on the cases of two children with rhabdomyolysis and acute kidney injury are presented.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics