Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin/mitomycin C resistance in other bacteria

January 2011
BMC Structural Biology;2011, Vol. 11 Issue 1, p33
Academic Journal
The article examines the crystal structure of EhpR, a small gene of plant-colonizing bacterium Enterobacter agglomerans, to understaNDits resistance mechanism. It is mentioned that although,EhpR shares a common fold with glyoxalase-I/bleomycin resistance proteins, the ligand binding site does not contain residues. It is also found that EhpR confers resistance by binding D-alanyl-griseoluteic acid and acting as a chaperone involved in exporting the antibiotic.


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