No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data

January 2011
BMC Psychiatry;2011, Vol. 11 Issue 1, p151
Academic Journal
The article presents a research which examines whether there exists an association between catechol-o-methyl-transferase (COMT) val158met and suicidal behavior. It is reported that, COMT is a catabolic enzyme for catecholaminergic neurotransmitters in the brain. According to the research, there exists no association between COMTmet and suicidal behavior.


Related Articles

  • Repetition of suicide attempts across episodes of severe depression Behavioural sensitisation found in suicide group but not in controls. Brådvik, Louise; Berglund, Mats // BMC Psychiatry;2011, Vol. 11 Issue 1, p1 

    Background: Those who die by suicide and suffer from depression are known to have made more suicide attempts during their life-span as compared to other people with depression. A behavioural sensitisation or kindling model has been proposed for suicidal behaviour, in accordance with a...

  • The association between bullying and early stages of suicidal ideation in late adolescents in Greece. Skapinakis, Petros; Bellos, Stefanos; Gkatsa, Tatiana; Magklara, Konstantina; Lewis, Glyn; Araya, Ricardo; Stylianidis, Stelios; Mavreas, Venetsanos // BMC Psychiatry;2011, Vol. 11 Issue 1, p22 

    Background: Bullying in schools has been associated with suicidal ideation but the confounding effect of psychiatric morbidity has not always been taken into account. Our main aim was to test the association between bullying behavior and early stages of suicidal ideation in a sample of Greek...

  • Gender differences in suicidal expressions and their determinants among young people in Cambodia, a post-conflict country. Jegannathan, Bhoomikumar; Kullgren, Gunnar // BMC Psychiatry;2011, Vol. 11 Issue 1, p47 

    Background: Suicide among young people is a global public health problem, but adequate information on determinants of suicidal expression is lacking in middle and low income countries. Young people in transitional economies are vulnerable to psychosocial stressors and suicidal expressions. This...

  • ALGOS: the development of a randomized controlled trial testing a case management algorithm designed to reduce suicide risk among suicide attempters. Vaiva, Guillaume; Walter, Michel; Arab, Abeer S. Al; Courtet, Philippe; Bellivier, Frank; Demarty, Anne Laure; Duhem, Stephane; Ducrocq, Francois; Goldstein, Patrick; Libersa, Christian // BMC Psychiatry;2011, Vol. 11 Issue 1, p1 

    Background: Suicide attempts (SA) constitute a serious clinical problem. People who attempt suicide are at high risk of further repetition. However, no interventions have been shown to be effective in reducing repetition in this group of patients. Methods/Design: Multicentre randomized...

  • Suicide attempts and related factors in patients admitted to a general hospital: a ten-year crosssectional study (1997-2007). Alberdi-Sudupe, Jesús; Pita-Fernández, Salvador; Gómez-Pardiñas, Sonia M.; Iglesias-Gil-de-Bernabé, Fernando; García-Fernández, Jorge; Martínez-Sande, Gonzalo; Lantes-Louzao, Sara; Pértega-Díaz, Sonia // BMC Psychiatry;2011, Vol. 11 Issue 1, p51 

    Background: Suicide and suicide attempts represent a severe problem for public health services. The aim of this study is to determine the socio-demographic and psychopathological variables associated with suicide attempts in the population admitted to a General Hospital. Methods: An...

  • EMSAM (deprenyl patch): how a promising antidepressant was underutilized. Asnis, Gregory M.; Henderson, Margaret A. // Neuropsychiatric Disease & Treatment;2014, Vol. 10, p1911 

    The EMSAM patch is a unique monoamine oxidase inhibitor (MAOI) being the only antidepressant utilizing a transdermal delivery system. This was welcomed by clinicians who hoped that EMSAM would be better tolerated than oral MAOIs and non-MAOI antidepressants, as well as being effective for...

  • Suicide risk with anticonvulsants. Kuritzky, Louis // Primary Care Reports;Jul2010 Clinical Briefs, p14 

    The article presents a study by Patorno et al., published in the "Journal of the American Medical Association," which examined the suicidal behavior/ideation among patients receiving anticonvulsants.

  • Suicide risk with anticonvulsants. Kuritzky, Louis // Clinical Oncology Alert;Jul2010 Supplement, p14 

    The article presents a study by Patorno et al., published in the "Journal of the American Medical Association," which examined the suicidal behavior/ideation among patients receiving anticonvulsants.

  • Variants in COMT and DBH Influence on Response Inhibition Ability in Chinese Han Females. Gong, Pingyuan; Li, Jing; Chi, Wanyu; Wang, Jian; Yao, Tianbao; Zhang, Kejin; Gao, Xiaocai; Zhang, Fuchang // Cellular & Molecular Neurobiology;Nov2011, Vol. 31 Issue 8, p1163 

    Catechol- O-methyltransferase (COMT) and dopamine-beta hydroxylase (DBH) are key enzymes to breakdown dopamine. Some previous studies have indicated that val158met in COMT and 19 bp insertion/deletion in 5′ flank of DBH are related to the performance of executive function. To further...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics