TITLE

Metabolic syndrome among patients receiving clozapine: A preliminary estimate

AUTHOR(S)
Grover, Sandeep; Nebhinani, Naresh; Chakrabarti, Subho; Avasthi, Ajit; Kulhara, Parmanand
PUB. DATE
October 2011
SOURCE
Indian Journal of Pharmacology;Oct2011, Vol. 43 Issue 5, p591
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To study the prevalence of metabolic syndrome in patients receiving clozapine. Materials and Methods: For this study, 100 patients attending the psychiatry outpatient clinic of a tertiary care hospital who were receiving clozapine for more than three months were evaluated for the presence of metabolic syndrome using the International Diabetes Federation (IDF) and modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III) criteria. Results: Forty-six patients fulfilled IDF criteria and 47 met modified NCEP ATP-III criteria of metabolic syndrome. There was significant correlation between these two sets of criteria used to define the metabolic syndrome (Kappa value -0.821, P < 0.001). Among the individual parameters studied, increased waist circumference was the most common abnormality, followed by abnormal blood glucose levels and elevated triglyceride levels. All these abnormalities were seen in more than half (52-61%) of the patients. When the sample was divided into two groups, i.e., those with and without metabolic syndrome, patients with metabolic syndrome had significantly higher body mass index and had spent more time in school. Logistic regression analysis revealed that these two variables together explained about 19% of the variance in metabolic syndrome (adjusted r2 = 0193; F = 12.8; P < 0.001). Conclusion: The findings of the present study suggest that metabolic syndrome is highly prevalent in subjects receiving clozapine.
ACCESSION #
66573354

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics