Human Herpesvirus-8 Encoded Kaposin: Subcellular Localization Using Immunofluorescence and Biochemical Approaches
- Expression of human herpesvirus 8-encoded cyclin D in Kaposi's sarcoma spindle cells. Davis, Monica A.; Blasig, Cornelia; Sturzl, Michael; Schreier, Anneliese; Hong-Guang Guo; Reitz, Marvin; Opalenik, Susan R.; Browning, Philip J. // JNCI: Journal of the National Cancer Institute;12/17/97, Vol. 89 Issue 24, p1868
Studies the expression of human herpesvirus 8-encoded cyclin D gene in Kaposi's sarcoma spindle cells. Detection of v-cyclin D transcripts by means of reverse transcriptase-polymerase chain reaction analysis and in situ hybridization; Isolation of v-cyclin D complementary DNA.
- Kaposi's Sarcoma Associated Herpes Virus (KSHV) Induced COX-2: A Key Factor in Latency, Inflammation, Angiogenesis, Cell Survival and Invasion. Sharma-Walia, Neelam; Paul, Arun George; Bottero, Virginie; Sadagopan, Sathish; Veettil, Mohanan Valiya; Kerur, Nagaraj; Chandran, Bala // PLoS Pathogens;Feb2010, Vol. 6 Issue 2, p1
Kaposi's sarcoma (KS), an enigmatic endothelial cell vascular neoplasm, is characterized by the proliferation of spindle shaped endothelial cells, inflammatory cytokines (ICs), growth factors (GFs) and angiogenic factors. KSHV is etiologically linked to KS and expresses its latent genes in KS...
- Molecular Polymorphism of Kaposi's Sarcoma--Associated Herpesvirus (Human Herpesvirus 8) Latent Nuclear Antigen: Evidence for a Large Repertoire of Viral Genotypes and Dual Infection with Different Viral Genotypes. Shou-Jiang Gao; Yan-Jin Zhang; Jian-Hong Deng; Rabkin, Charles S.; Flore, Ornella; Jenson, Hal B. // Journal of Infectious Diseases;11/1/99, Vol. 180 Issue 5, p1466
Studies the molecular polymorphism of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen. Properties of Kaposi's sarcoma-associated herpesvirus-infected cell lines and molecular polymorphism of latent nuclear antigen (LNA); LNA molecular polymorphism.
- Abstracts. // JAMA: Journal of the American Medical Association;2/15/95, Vol. 273 Issue 7, p516
Presents an abstract of the study `Identification of Herpesvirus-Like DNA Sequences in AIDS-Associated Kaposi's Sarcoma,' by Yuan Chang et al. published in the 1994 issue of the periodical `Science.' Isolation of unique sequences present in Kaposi's sarcoma tissues obtained from AIDS patients;...
- Coupling herpesvirus to angiogenesis. Boshoff, Chris // Nature;1/1/1998, Vol. 391 Issue 6662, p24
Describes research which reported that the G-protein-coupled receptor (GPCR) encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) induces an angiogenic switch in transformed NIH3T3 cells. Spindle cells in KSHV; KSHV-GPCR fully active in absence of chemokine ligands; Other viral oncogenes...
- G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Bais, Carlos; Santomasso, Bianca; Coso, Omar; Arvanitakis, Leandros; Geras Raaka, Elizabeth; Gutkind, J. Silvio; Asch, Adam S.; Cesarman, Ethel; Gershengorn, Marvin C.; Mesri, Enrique A. // Nature;1/1/1998, Vol. 391 Issue 6662, p86
Presents research which showed that signaling by the Kaposi's sarcoma-associated herpesvirus (KSHV-HHV8) G-protein-coupled receptor leads to cell transformation and tumorigenicity, and induces a switch to an angiogenic phenotype mediated by vascular endothelial growth factor. Activity of...
- Kaposi's Sarcoma-Associated Herpesvirus ORF45 Interacts with Kinesin-2 Transporting Viral Capsid-Tegument Complexes along Microtubules. Narayanan Sathish; Fan Xiu Zhu; Yan Yuan // PLoS Pathogens;Mar2009, Vol. 5 Issue 3, p1
Open reading frame (ORF) 45 of Kaposi's sarcoma-associated herpesvirus (KSHV) is a tegument protein. A genetic analysis with a null mutant suggested a possible role for this protein in the events leading to viral egress. In this study, ORF45 was found to interact with KIF3A, a kinesin-2 motor...
- 'Gay' cancer linked to genetic factors. Trow, Robert // Body Politic;Mar82, Issue 81, p15
Reports on studies on the genetic predisposition of gay men to Kaposi's sarcoma (KS). Statistics on reported cases in Canada and the U.S. Factors contributing to KS susceptibility; Role of antigens HLADR5 and DR6.
- Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus. Flore, Ornella; Rafii, Shahin; Ely, Scott; O'Leary, John J.; Hyjek, Elizabeth M.; Cesarman, Ethel // Nature;8/6/1998, Vol. 394 Issue 6693, p588
States that Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 is invariably present in Kaposi's sarcoma lesions. The viral oncogenes and serological evidence which suggests that KSHV infection is necessary for the development of Kaposi's sarcoma; Finding that the infection...