TITLE

Extracapular Extension Predictors of Prostate Carcinoma for 2-10 ngr/ml PSA Values

AUTHOR(S)
Kulovac, Benjamin; Aganovic, Damir; Prcic, Alden; Hadziosmanovic, Osman; Eminagic, Dzenana; Obralic, Nermina
PUB. DATE
June 2011
SOURCE
Medical Archives / Medicinski Arhiv;2011, Vol. 65 Issue 3, p160
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose of the research is to establish which clinical and biopsy parameters could predict extra-capsular spread of prostate carcinoma for 2-10 ng/ml PSA values, in patients submitted to radical retropubic prostatectomy. Methodology: In the period of 30 months, 80 patients were treated with radical retro-pubic prostatectomy with bilateral pelvic lymphadenectomy, for whom clinical, biopsy, radiological and biochemical analysis were positive to organ limited tumor. Serum PSA, fpsa/tpsa, PSAD,values are evaluated, and other parameters as number of positive biopsies, percentage of positive biopsies, localization of positive biopsies, and perineural invasion and biopsy Gleason score. Results: from total number of 80 patients with 2-10 ng/ml PSA, 7 (9%) patients had extra-capsular spread of prostate carcinoma. Upon using multivariate regression analysis, following parameters were proved as significant predictors of extra-capsular spread: biopsy Gleason score, number of positive biopsy samples and invasion, while serum PSA, FPSA/TPSA ratio, PSAD, prostate age and volume have not shown as significant predictors for extra-capsular extension. Conclusion: Biopsy GS, perineural invasion and number of biopsy samples are statistically significant predictors of extra-capsular spread of prostate carcinoma for 2-10 ml PSA. Percentage of positive biopsies, tumor length in a sample and the localization of positive biopsies are on the borderline of statistical significance and as such should be taken into consideration.
ACCESSION #
66347075

 

Related Articles

  • What would happen if neurovascular bundles were left behind in radical retropubic prostatectomy? AKBULUT, Ziya; KANDEMİR, Olcay; ATMACA, Ali Fuat; DEMİRCİ, Durmuş Alparslan; DOĞAN, Bayram; CANDA, Abdullah Erdem; BALBAY, Mevlana Derya // Turkish Journal of Medical Sciences;Jun2013, Vol. 43 Issue 3, p448 

    Aim: To evaluate whether nerve-sparing radical prostatectomy (NSRP) results in a residual tumor in the remaining neurovascular bundle (NVB). Materials and methods: A total of 88 patients underwent bilateral NSRP. The ipsilateral NVB was excised uni-/bilaterally on the tumor side, separately....

  • Increased rate of positive biopsies using a combination of MR-Tomography, spectroscopy and diffusion-weighted magnetic resonance imaging prior to prostate biopsies in patients with persistent elevated prostate-specific antigen values: A retrospective analysis Lunacek, A.; Simon, J.; Bernt, R.; Huber, M.; Plas, E.; Mrstik, C. // Urology Annals;Apr2013, Vol. 5 Issue 2, p76 

    Purpose: Persistently elevated prostate-specific antigen (PSA) values following negative biopsies result in a diagnostic dilemma. In order to improve detection rates in patients with former negative biopsies and persistently elevated PSA values, magnetic resonance tomography (MRT), magnetic...

  • Validation of revised Epstein's criteria for insignificant prostate cancer prediction in a Greek subpopulation. Chondros, K.; Karpathakis, N.; Heretis, I.; Mavromanolakis, E.; Chondros, N.; Sofras, F.; Mamoulakis, C. // Hippokratia;2015, Vol. 19 Issue 1, p30 

    Background: Different treatment options for patients with prostate cancer (PCa) are applicable after stratifying patients according to various classification criteria. The purpose of our study is to evaluate the revised Epstein's criteria for insignificant PCa prediction in a Greek...

  • Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy. Gilbert, Rebecca; Martin, Richard M.; Evans, David M.; Tilling, Kate; Davey Smith, George; Kemp, John P.; Lane, J. Athene; Hamdy, Freddie C.; Neal, David E.; Donovan, Jenny L.; Metcalfe, Chris // PLoS ONE;10/2/2015, Vol. 10 Issue 10, p1 

    Introduction: Prostate-specific antigen (PSA) testing is a widely accepted screening method for prostate cancer, but with low specificity at thresholds giving good sensitivity. Previous research identified four single nucleotide polymorphisms (SNPs) principally associated with circulating PSA...

  • Prostate Cancer Predicting Factors. Pourmand, Gholamreza; Allameh, Farzad; Mohammad, Kazem; Dehghani, Sanaz; Pourmand, Bita; Mehrsai, Abdolrasoul; Hosseini, Seyed Hamed // Urology Journal;Autumn2012, Vol. 9 Issue 4, p667 

    Purpose: To determine the probability of having prostate cancer (PCa) using the combination of serum level of prostate-specific antigen (PSA) and age. Materials and Methods: A total of 160 patients and 190 controls were enrolled in this hospital- based case-control study. Using a logistic...

  • Pathological findings and oncological control afforded by radical prostatectomy in men with high-risk prostate cancer: a single-centre study. Masson-Lecomte, Alexandra; Hupertan, Vincent; Comperat, Eva; Vaessen, Christophe; Chartier-Kastler, Emmanuel; Cussenot, Olivier; Bitker, Marc-Olivier; Roupr�t, Morgan // World Journal of Urology;Oct2011, Vol. 29 Issue 5, p665 

    Objective: To assess pathological findings and oncological control afforded by radical prostatectomy (RP) in high-risk prostate cancers (PCa) at our institution. Materials and methods: We performed a retrospective review of prostate cancer patients who underwent RP between 1995 and 2006 for a...

  • Assay-specific artificial neural networks for five different PSA assays and populations with PSA 2–10 ng/ml in 4,480 men. Stephan, Carsten; Chuanliang Xu; Cammann, Henning; Graefen, Markus; Haese, Alexander; Huland, Hartwig; Semjonow, Axel; Diamandis, Eleftherios P.; Remzi, Mesut; Djavan, Bob; Wildhagen, Mark F.; Blijenberg, Bert G.; Finne, Patrik; Stenman, Ulf-Hakan; Klaus Jung; Meyer, Hellmuth-Alexander // World Journal of Urology;Feb2007, Vol. 25 Issue 1, p95 

    Use of percent free PSA (%fPSA) and artificial neural networks (ANNs) can eliminate unnecessary prostate biopsies. In a total of 4,480 patients from five centers with PSA concentrations in the range of 2–10 ng/ml an IMMULITE PSA-based ANN (iANN) was compared with other PSA assay-adapted...

  • When Naked Became Armored: An Eight-Gene Phylogeny Reveals Monophyletic Origin of Theca in Dinoflagellates. Orr, Russell J. S.; Murray, Shauna A.; Stüken, Anke; Rhodes, Lesley; Jakobsen, Kjetill S. // PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1 

    The dinoflagellates are a diverse lineage of microbial eukaryotes. Dinoflagellate monophyly and their position within the group Alveolata are well established. However, phylogenetic relationships between dinoflagellate orders remain unresolved. To date, only a limited number of dinoflagellate...

  • Reproducibility, Performance, and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese. Akamatsu, Shusuke; Takahashi, Atsushi; Takata, Ryo; Kubo, Michiaki; Inoue, Takahiro; Morizono, Takashi; Tsunoda, Tatsuhiko; Kamatani, Naoyuki; Haiman, Christopher A.; Wan, Peggy; Chen, Gary K.; Le Marchand, Loic; Kolonel, Laurence N.; Henderson, Brian E.; Fujioka, Tomoaki; Habuchi, Tomonori; Nakamura, Yusuke; Ogawa, Osamu; Nakagawa, Hidewaki // PLoS ONE;Oct2012, Vol. 7 Issue 10, Special section p1 

    Prostate specific antigen (PSA) is widely used as a diagnostic biomarker for prostate cancer (PC). However, due to its low predictive performance, many patients without PC suffer from the harms of unnecessary prostate needle biopsies. The present study aims to evaluate the reproducibility and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics