Nitric oxide in acute ischaemic stroke: a target for neuroprotection

July 1999
Journal of Neurology, Neurosurgery & Psychiatry;Jul1999, Vol. 67 Issue 1, p1
Academic Journal
No abstract available.


Related Articles

  • Inhalation Gases or Gaseous Mediators As Neuroprotectants for Cerebral Ischaemia. Sutherland, Brad A.; Harrison, Joanne C.; Nair, Shiva M.; Sammut, Ivan A. // Current Drug Targets;Feb2013, Vol. 14 Issue 2, p56 

    Ischaemic stroke is one of the leading causes of morbidity and mortality worldwide. While recombinant tissue plasminogen activator can be administered to produce thrombolysis and restore blood flow to the ischaemic brain, therapeutic benefit is only achieved in a fraction of the subset of...

  • Potential of immunosuppressive agents in cerebral ischaemia. Gupta, Yogendra Kumar; Chauhan, Anjali // Indian Journal of Medical Research;Jan2011, Vol. 133 Issue 1, p15 

    Ischaemic stroke is a disorder involving multiple mechanisms of injury progression including activation of glutamate receptors, release of proinflammatory cytokines, nitric oxide (NO), free oxygen radicals and proteases. Presently, recombinant tissue plasminogen activator (rtPA) is the only drug...

  • Do statins afford neuroprotection in patients with cerebral ischaemia and stroke? Vaughan, C.J.; delanty, N.; Basson, C.T. // CNS Drugs;2001, Vol. 15 Issue 8, p589 

    An emerging body of evidence indicates that beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or 'statins', provide neuroprotection in addition to reducing ischaemic stroke. Statins reduce the incidence of ischaemic stroke by stabilising atherosclerotic plaques in the...

  • Neuroprotective Effects of Free Radical Scavengers in Stroke. Chen X. Wang; Shuaib, Ashfaq // Drugs & Aging;2007, Vol. 24 Issue 7, p537 

    Acute ischaemic stroke is a leading cause of death in the majority of industrialised countries and also in many developing countries. Free radicals are generated in the brain during ischaemic injury and these radicals are involved in the secondary injury processes. Several free radical...

  • Neuroprotection in acute ischaemic stroke. II: Clinical potential. Davis, M.; Barer, D. // Vascular Medicine;1999, Vol. 4 Issue 3, p149 

    In the 4 years since our first article, there has been considerable progress in our under-standing of the pathophysiology of acute ischaemic stroke, and the results of well-conducted trials have at last begun to change everyday clinical practice. The timing of the various pro-cesses of the...

  • Cortical plasticity: Plasticity gets sex-specific. Yates, Darran // Nature Reviews Neuroscience;Dec2012, Vol. 13 Issue 12, p817 

    The article offers information on nitric oxide synthase 1(NOS1), which has roles in plasticity and NOS1alpha, plays a part in stroke by contributing to ischaemic damage and this effect is greater in males.

  • Pharmacological therapies in post stroke recovery: recommendations for future clinical trials. Chollet, F.; Cramer, S.; Stinear, C.; Kappelle, L.; Baron, J.; Weiller, C.; Azouvi, P.; Hommel, M.; Sabatini, U.; Moulin, T.; Tardy, J.; Valenti, M.; Montgomery, S.; Adams, H. // Journal of Neurology;Aug2014, Vol. 261 Issue 8, p1461 

    Stroke is a leading cause of serious long-term disability in adults and is the second leading cause of death worldwide. Early reperfusion and neuroprotection techniques have been the focus of much effort with the aim of very acute treatment of the stroke. Targeting different mechanisms,...

  • Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing. O'Collins, Victoria E; Macleod, Malcolm R; Cox, Susan F; Van Raay, Leena; Aleksoska, Elena; Donnan, Geoffrey A; Howells, David W // Journal of Cerebral Blood Flow & Metabolism;Mar2011, Vol. 31 Issue 3, p962 

    There is some evidence that in animal models of acute ischaemic stroke, combinations of neuroprotective agents might be more efficacious than the same agents administered alone. Hence, we developed pragmatic, empirical criteria based on therapeutic target, cost, availability, efficacy,...

  • Acute ischaemic stroke. Gubitz, Gord // BMJ: British Medical Journal (International Edition);03/11/2000, Vol. 320 Issue 7236, p692 

    Presents a study on acute ischaemic stroke. Definition of stroke; Percentage of acute strokes caused by cerebral infarction; Effects of specialized care in people with stroke; Effect of medical treatment, such as trombolysis, in acute ischaemic stroke.

  • Brain ischaemia, new patterns and treatments.  // Journal of Neurology;May2006 Supplement 2, Vol. 253, pII3 

    The article presents abstracts of medical research related to ischaemia. They include "White Matter Ischaemic Syndromes" by M. Hennerici, "Present and future of acute stroke therapy," and "Penumbra Is Brain: Targeted Neuro-Imaging in Hyperacute Stroke."


Read the Article


Sign out of this library

Other Topics