TITLE

Absence of genetic linkage of chromosome 5q31 with asthma and atopy in the general population

AUTHOR(S)
Kamitani, Atsushi; Wong, Zilla Y. H.; Dickson, Phillip; van Herwerden, Lynne; Raven, Joan; Forbes, Andrew B.; Abramson, Michael J.; Walters, E. Haydn; Harrap, Stephen B.
PUB. DATE
September 1997
SOURCE
Thorax;Sep1997, Vol. 52 Issue 9, p816
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
66299148

 

Related Articles

  • Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region. Palmer, Lyle J. // Human Molecular Genetics;Apr2001, Vol. 10 Issue 8, p891 

    Studies the relationship between asthma and atopy in the chromosome 5q1-33 candidate region. Complication of gene discovery in asthma by substantial etiological heterogeneity; Linkage to asthma phenotypes.

  • Linkage analysis of the 5q31—33 candidate region for asthma in 240 UK families. Holloway, J W; Lonjou, C; Beghé, B; Peng, Q; Gaunt, T R; Gomes, I; Hall, I P; Dewar, J C; Wilkinson, J; Thomas, N S; Holgate, S T; Morton, N E // Genes & Immunity;Feb2001, Vol. 2 Issue 1, p20 

    Atopy and asthma are complex genetic diseases resulting from the interactions of a number of genetic and environmental factors. We had previously reported allelic association between the IL9 marker on chromosome 5q31–33 and atopy. In order to further investigate the role of susceptibility...

  • Evidence for association and linkage between atopy, airway hyper-responsiveness, and the β subunit Glu237Gly variant of the high-affinity receptor for immunoglobulin E in the French-Canadian population. Laprise, Catherine; Boulet, Louis-Philippe; Morissette, Jean; Winstall, Eric; Raymond, Vincent // Immunogenetics;Jul2000, Vol. 51 Issue 8/9, p695 

    Following detection of linkage between atopy and chromosome 11q13 markers, association between this disorder and variants of the β subunit of the high-affinity receptor for immunoglobulin E (FcεRI-β, a candidate gene for asthma-related conditions co-localizing within the same region)...

  • Association and Linkage of Atopic Dermatitis with Chromosome 13q12–14 and 5q31–33 Markers. Beyer, Kirsten; Nickel, Renate; Freidhoff, Linda; Björkstén, Bengt; Huang, Shau-Ku; Barnes, Kathleen C.; MacDonald, Susan; Forster, Johannes; Zepp, Fred; Wahn, Volker; Beaty, Terri H.; Marsh, David G.; Wahn, Ulrich // Journal of Investigative Dermatology;Nov2000, Vol. 115 Issue 5, p906 

    Summary Atopic dermatitis is a chronic inflammatory skin disease that affects 10–20% of the population. Linkage of atopy, asthma, allergic rhinitis, and total serum IgE levels to several different chromosomal regions have been described extensively, but little is known about the genetic...

  • The gene encoding interleukin-13: a susceptibility locus for asthma and related traits. Wills-Karp, Marsha // Respiratory Research;2000, Vol. 1, p19 

    Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been...

  • Meta-analysis for linkage to asthma and atopy in the chromosome 5q31–33 candidate region. Palmer, Lyle J.; Barnes, Kathleen C.; Burton, Paul R.; Chen, Hong; Cookson, William O. C. M.; Deichmann, Klaus A.; Elston, Robert C.; Holloway, John W.; Jacobs, Kevin B.; Laitinen, Tarja; Wjst, Matthias // Human Molecular Genetics;Apr2001, Vol. 10 Issue 8, p891 

    Asthma is a common, complex human disease. Gene discovery in asthma has been complicated by substantial etiological heterogeneity, the possibility of genes of small effect and the concomitant requirement for large sample sizes. Linkage to asthma phenotypes has been investigated most intensively...

  • Meta-analysis of genome-wide linkage studies of asthma and related traits. Denham, Samuel; Koppelman, Gerard H.; Blakey, John; Wjst, Matthias; Ferreira, Manuel A.; Hall, Ian P.; Sayers, Ian // Respiratory Research;2008, Vol. 9, Special section p1 

    Background: Asthma and allergy are complex multifactorial disorders, with both genetic and environmental components determining disease expression. The use of molecular genetics holds great promise for the identification of novel drug targets for the treatment of asthma and allergy. Genome-wide...

  • A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma. Blumenthal, Malcolm N.; Langefeld, Carl D.; Beaty, Terri H.; Bleecker, Eugene R.; Ober, Carole; Lester, Lucille; Lange, Ethan; Barnes, Kathleen C.; Wolf, Raoul; King, Richard A.; Solway, Julian; Oetting, William; Meyers, Deborah A.; Rich, Stephen S. // Human Genetics;Jan2004, Vol. 114 Issue 2, p157 

    Atopy is an IgE-mediated condition known to aggregate in families and is a major risk factor for asthma. As part of the Collaborative Study on the Genetics of Asthma (CSGA), a genome-wide scan for atopy, defined by skin sensitivity to one or more common environmental allergens, was conducted in...

  • A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. Laitinen, Tarja; Daly, Mark J.; Rioux, John D.; Kauppi, Paula; Laprise, Catherine; Petäys, Tuula; Green, Todd; Cargill, Michele; Haahtela, Tari; Lander, Eric S.; Laitinen, Lauri A.; Hudson, Thomas J.; Kere, Juha // Nature Genetics;May2001, Vol. 28 Issue 1, p87 

    The genetics of asthma and atopy have been difficult to determine because these diseases are genetically heterogeneous and modified by environment. The pedigrees in our study (n=86) originate in eastern central Finland (Kainuu province). According to census records, this region had only 200...

  • Significant linkage to chromosome 12q24.32-q24.33 and identification of SFRS8 as a possible asthma susceptibility gene. Brasch-Andersen, C.; Tan, Q.; Borglum, A. D.; Haagerup, A.; Larsen, T. R.; Vestho, J.; Kruse, T. A.; Børglum, A D; Vestbo, J // Thorax;Oct2006, Vol. 61 Issue 10, p874 

    Background: Asthma is a complex genetic disorder. Many studies have suggested that chromosome 12q harbours a susceptibility gene for asthma and atopy. Linkage on chromosome 12q24.21-q24.33 was investigated in 167 Danish families with asthma. Methods: A two step...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics