TITLE

Protective Effect of Vitamins C and E on Malathion-Induced Nephrotoxicity in Male Rats

AUTHOR(S)
UZUN, Fatma Gökçe; KALENDER, Yusuf
PUB. DATE
April 2011
SOURCE
Gazi University Journal of Science;2011, Vol. 24 Issue 2, p193
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The male Wistar rats were given malathion and/or vitamin C+vitamin E daily via gavage for 4 weeks. When malathion-, vitamins C+E plus malathion-treated groups were compared to control, body and kidney weights decreased; serum urea, uric acid and creatinine levels increased significantly. Vitamins C+E plus malathion-treated group was compared to malathion-treated group there were statistically decrease in the serum urea level, while no significant changes were observed in other parameters. Light microscopic investigations revealed that both the malathion- and vitamins C+E plus malathion-treated groups exhibited histopathological changes in kidney. It appears that vitamins C and E didn't ameliorate malathion-induce nephrotoxicity.
ACCESSION #
66297629

 

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