Protective Effect of Vitamins C and E on Malathion-Induced Nephrotoxicity in Male Rats

UZUN, Fatma Gökçe; KALENDER, Yusuf
April 2011
Gazi University Journal of Science;2011, Vol. 24 Issue 2, p193
Academic Journal
The male Wistar rats were given malathion and/or vitamin C+vitamin E daily via gavage for 4 weeks. When malathion-, vitamins C+E plus malathion-treated groups were compared to control, body and kidney weights decreased; serum urea, uric acid and creatinine levels increased significantly. Vitamins C+E plus malathion-treated group was compared to malathion-treated group there were statistically decrease in the serum urea level, while no significant changes were observed in other parameters. Light microscopic investigations revealed that both the malathion- and vitamins C+E plus malathion-treated groups exhibited histopathological changes in kidney. It appears that vitamins C and E didn't ameliorate malathion-induce nephrotoxicity.


Related Articles

  • The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat erythrocytes: role of vitamins E and C. Sutcu, Recep; Altuntas, Irfan; Buyukvanli, Bora; Akturk, Onur; Ozturk, Ozlem; Koylu, Halis; Delibas, Namik // Toxicology & Industrial Health;2007, Vol. 23 Issue 1, p13 

    Reactive oxygen species caused by organophosphates may be involved in the toxicity of various pesticides. Therefore, in this study, we aimed to investigate the effects of acute exposure to organophosphate insecticide diazinon (DI) and possible ameliorating role of vitamins E and C, with the...

  • Ovarian toxicity in rats caused by methidathion and ameliorating effect of vitamins E and C. Güney, Mehmet; Demirin, Hilmi; Oral, Baha; Özgüner, Meltem; Bayhan, Gökhan; Altuntas, Irfan // Human & Experimental Toxicology;Jun2007, Vol. 26 Issue 6, p491 

    We have investigated the effect of subchronic administration of methidathion (MD) on ovary evaluated ameliorating effects of vitamins E and C against MD toxicity. Experimental groups were as follows: control group; a group treated with 5 mg/kg body weight MD (MD group); and a group treated with...

  • Vitamin C dose-dependently ameliorates renal hemodynamic toxicity of cisplatin in adult Swiss albino rats: a histopathologic and biochemical study. Bidadkosh, Arash; Eini, Fatemeh; Mohseni, Maryam; Rastegar, Amir; Fallahi, Hamid; Roshanzamir, Majid; Yazdani, Saleh // Comparative Clinical Pathology;Mar2014, Vol. 23 Issue 2, p269 

    Nephrotoxicity is usually thought of as a common invariable consequence of hemodynamic toxicity whose effects, including oliguria and dysuria, has largely limited the clinical use of cisplatin. In this study, we investigated the protective effects of low and high dose of vitamin C against...

  • The effects of desferrioxamine on cisplatin-induced lipid peroxidation and the activities of antioxidant enzymes in rat kidneys. Kadikoylu, G.; Bolaman, Z.; Demir, S.; Balkaya, M.; Akalin, N.; Enli, Y. // Human & Experimental Toxicology;Jan2004, Vol. 23 Issue 1, p29 

    Cisplatin-induced nephrotoxicity is associated with an increase in lipid peroxidation and oxygen free radicals in rat kidneys. In this study, the effects of desferrioxamine were compared to vitamin C and E on cisplatin-induced lipid peroxidation and antioxidant enzyme activities in rat kidneys....

  • Reno-protective effect of Naringenin in combination with vitamins C and E on cadmium induced oxidative nephrotoxicity in rats. Prabu, S. Milton; Shagirtha, K.; Renugadevi, J. // Journal of Pharmacy Research;Jun2011, Vol. 4 Issue 6, p1921 

    Cadmium (Cd) induced oxidative stress and renal injury is one of the major outcomes of the chronic Cd toxicity, which can be ameliorated by numerous antioxidants. This study was aimed to evaluate the therapeutic efficacy of the combined pretreatment with naringenin (NGN) in combination with...

  • Combined effects of treatment with vitamin C, vitamin E and selenium on the skin of diabetic rats. Sokmen, BB; Basaraner, H; Yanardag, R // Human & Experimental Toxicology;Apr2013, Vol. 32 Issue 4, p379 

    The aim of this study was to investigate the effects of vitamin C, vitamin E and selenium (Se) on the skin tissue of streptozotocin-induced diabetic rats. Swiss albino rats were divided into four groups: control, control + antioxidants, diabetic, diabetic + antioxidants groups. Diabetes was...

  • EFFECTS OF SUPPLEMENTATION WITH VITAMIN E ON GENTAMYCIN-INDUCED ACUTE RENAL FAILURE IN RATS. Stojiljković, Nenad; Ilić, Sonja; Veljković, Milica; Todorović, Jovan // Facta Universitatis, Series: Medicine & Biology;2014, Vol. 16 Issue 2, p61 

    A frequent administration of gentamicin in clinical practice has shown its bactericidal activity, and besides being vestibulotoxic it is highly nephrotoxic, which can further result in acute renal insufficiency. The study analyzed 24 Wistar rats, divided into three equal groups. GM group...

  • Histological effects of cinnamon on nephrotoxicity resulted from Gentimicin in rats. Tanomand, Sedigheh; Nahid, Alaeyan Jahromi; Zahra, Alaeyan Jahromi; Houshang, Jamali; Majid, Alaeyan Jahromi; Reza, Alaeyan Jahromi Ali // Advances in Environmental Biology;2014 Special, Vol. 8 Issue 16, p11 

    Background and objective: Gentimicin is an antibiotic from the family of Aminoglycosides used in the treatment of infections resulted from Gram-negative bacteria, the use of which is limited due to its nephrotoxicity. In this study the histological effect of cinnamon on the nephrotoxicity...

  • Plasma, erythrocyte membrane bound enzymes and tissue histopathology in male Wistar rats exposed to common insecticides. NWOZO, Sarah; AKPODONO, Enor; OYINLOYE, Babatunji // Journal of Pesticide Science;2015, Vol. 40 Issue 1, p13 

    Low doses (one-fourth of the LD50) of dichlorvos (DDVP), lambda-cyhalothrin (LMB), cypermethrin (CPM), and imidacloprid (IMP) were administered to adult male Wistar rats for 3 weeks. Erythrocyte antioxidant enzymes, biomarkers of tissue toxicity and histopathology of some visceral organs, were...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics