TITLE

Elevated levels of matrix metalloproteinases in bronchoalveolar lavage ?uid of emphysematous patients

AUTHOR(S)
Finlay, Geraldine A.; Russell, Kenneth J.; McMahon, Kevin J.; D'arcy, Elizabeth M.; Masterson, James B.; FitzGerald, Muiris X.; O'Connor, Clare M.
PUB. DATE
June 1997
SOURCE
Thorax;Jun1997, Vol. 52 Issue 6, p502
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
66296780

 

Related Articles

  • Untangling the protease web in COPD: metalloproteinases in the silent zone. Johnson, Simon R. // Thorax;Feb2016, Vol. 71 Issue 2, p105 

    The article discusses research on the association of specific aspects of the emphysema phenotype, such as small airway disease and emphysema, with bronchoalveolar lavage matrix metalloproteinase (MMP) and cytokine levels in chronic obstructive pulmonary disease (COPD) patients. It references a...

  • Sarcoidosis is a Th1/Th17 multisystem disorder: wider implications. Parisinos, C. A. // Thorax;Nov2011, Vol. 66 Issue 11, p1011 

    A letter to the editor is presented in response to an article in the previous issue by Facco that proved that elevated levels of T helper 17 cells in the peripheral blood and bronchoalveolar lavage of active sarcoidosis patients increased interleukin 17 expression in lung and lymph nodes.

  • Mononuclear Phagocytes and Airway Epithelial Cells: Novel Sources of Matrix Metalloproteinase-8 (MMP-8) in Patients with Idiopathic Pulmonary Fibrosis. Craig, Vanessa J.; Polverino, Francesca; Laucho-Contreras, Maria E.; Shi, Yuanyuan; Liu, Yushi; Osorio, Juan C.; Tesfaigzi, Yohannes; Pinto-Plata, Victor; Gochuico, Bernadette R.; Rosas, Ivan O.; Owen, Caroline A. // PLoS ONE;May2014, Vol. 9 Issue 5, p1 

    Objectives: Matrix metalloproteinase-8 (MMP-8) promotes lung fibrotic responses to bleomycin in mice. Although prior studies reported that MMP-8 levels are increased in plasma and bronchoalveolar lavage fluid (BALF) samples from IPF patients, neither the bioactive forms nor the cellular sources...

  • Production and Activation of Matrix Metalloproteinase 7 (Matrilysin 1) in the Lungs of Patients With Idiopathic Pulmonary Fibrosis. Fujishima, Seitaro; Shiomi, Takayuki; Yamashita, Shuji; Yogo, Yurika; Nakano, Yasushi; Inoue, Takashi; Nakamura, Morio; Tasaka, Sadatomo; Hasegawa, Naoki; Aikawa, Naoki; Ishizaka, Akitoshi; Okada, Yasunori // Archives of Pathology & Laboratory Medicine;Aug2010, Vol. 134 Issue 8, p1136 

    Context.--Idiopathic pulmonary fibrosis (IPF) is characterized by diffuse interstitial inflammation and fibroblast proliferation with accelerated remodeling of extracellular matrix, which result in irreversible destruction of the lung's architecture. Objective.--To elucidate the production...

  • Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis. Bergin, David A.; Hurley, Killian; Mehta, Adwait; Cox, Stephen; Ryan, Dorothy; O'Neill, Shane J.; Reeves, Emer P.; McElvaney, Noel G. // Journal of Inflammation Research;2013, Vol. 6, p1 

    Bronchiectasis is an airway disease characterized by thickening of the bronchial wall, chronic inflammation, and destruction of affected bronchi. Underlying etiologies include severe pulmonary infection and cystic fibrosis (CF); however, in a substantial number of patients with non-CF-related...

  • Type I collagenases in bronchoalveolar lavage fluid from preterm babies at risk of developing chronic lung disease. Sweet, D. G.; Mcmahon, K. J.; Curley, A. E.; O'Connor, C. M.; Halliday, H. L. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2001, Vol. 84 Issue 3, pF168 

    Objective--To assess whether increased collagenolysis precedes severe chronic lung disease (CLD). Methods--Matrix metalloproteinase-1 (MMP-1) and MMP-8 (enzymes that degrade type I collagen, the main structural protein of lung extracellular matrix) were measured by enzyme linked immunosorbent...

  • Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis. A G Richter // Thorax;Feb2009, Vol. 64 Issue 2, p156 

    BACKGROUND AND AIM: Aberrant angiogenesis and defective epithelial repair are key features of idiopathic pulmonary fibrosis (IPF). Endostatin is an antiangiogenic peptide with known effects on endothelial cells. This study aimed to establish the levels of endostatin in the bronchoalveolar lavage...

  • Matrix metalloproteinases 7 and 9 and their types 1 and 4 tissue inhibitors in tumors and plasma of patients with colorectal cancer. E. Gershtein; E. Korotkova; A. Shcherbakov; V. Prorokov; D. Golovkov; N. Kushlinskii // Bulletin of Experimental Biology & Medicine;Apr2007, Vol. 143 Issue 4, p459 

    Abstract  Enzyme immunoassays showed significantly elevated content of matrix metalloproteinase 7 and type 1 tissue inhibitor of metalloproteinases in tumors compared to adjacent histologically unchanged mucosa of patients with colorectal cancer; the levels of metalloproteinase 9 and type...

  • Enhanced cough reflex in a model of bleomycin-induced lung fibrosis in guinea pigs. Fernández-Blanco, Joan Antoni; Aguilera, Mònica; Domènech, Anna; Tarrasón, Gema; Prats, Neus; Miralpeix, Montse; De Alba, Jorge // Clinical Science;Dec2015, Vol. 129 Issue 12, p1001 

    Fibrotic lung diseases, such as idiopathic pulmonary fibrosis, are associated with spontaneous dry cough and hypersensitivity to tussive agents. Understanding the pathophysiology driving enhanced cough may help us to define better therapies for patients. We hypothesized that lung fibrosis...

  • Matrix Metalloproteinases 2, 7, and 9 and Tissue Inhibitor of Metalloproteinases-1 in Tumors and Serum of Patients with Ovarian Neoplasms. Gershtein, E.; Levkina, N.; Digayeva, M.; Laktionov, K.; Tereshkina, I.; Kushlinsky, N. // Bulletin of Experimental Biology & Medicine;May2010, Vol. 149 Issue 5, p628 

    The content of matrix metalloproteinases 7 and 9 was significantly increased, while the content of metalloproteinase 2 was reduced in ovarian cancer tissue compared to benign tumors. In blood serum from patients with ovarian cancer, the concentrations of matrix metalloproteinases 7 and 9 and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics