TITLE

Safety of a non-adjuvanted therapeutic vaccine for the treatment of feline dermatophytosis

AUTHOR(S)
Westhoff, D.; Orveillon, F. X.; Farnow, D.; Klös, M-C.; Elbers, K.
PUB. DATE
December 2010
SOURCE
Veterinary Record: Journal of the British Veterinary Association;Dec2010, Vol. 167 Issue 23, p899
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The safety of a non-adjuvanted inactivated fungal vaccine for the treatment of dermatophytosis in cats was investigated in two studies: a controlled laboratory study, and a placebo-controlled double-blind field study with a cross-over design in Europe. In the laboratory study, two groups of 10 cats each were administered an intramuscular twofold overdose, followed by five single 1 ml doses, of either vaccine or control product at 14-day intervals. In the field study, cats were treated with three intramuscular injections of 1 ml vaccine administered at 14-day intervals, as recommended by the manufacturer. A total of 89 cats were enrolled in the field study and divided into two groups to receive either vaccine or placebo for the first three treatments, followed by the opposite product for the final three treatments. The cats enrolled in the two studies were 12 weeks of age or older, as recommended by the manufacturer. All the cats were monitored closely for possible injection site reactions, systemic reactions (including changes in rectal body temperature) and adverse events. The results from both studies showed no significant differences between the vaccinated cats and the control or placebo-treated cats with regard to local or systemic reactions. A few mild to moderate local reactions were noted, but these were evenly distributed between the vaccinated and placebo-treated cats and resolved within a few days. No severe or serious adverse events related to the vaccinations were observed.
ACCESSION #
66291044

 

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