- Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet. Kassel, Karen M.; Guo, Grace L.; Tawfik, Ossama; Luyendyk, James P. // Laboratory Investigation (00236837);Dec2010, Vol. 90 Issue 12, p1794
Monocyte chemoattractant protein-1 (MCP-1, Ccl2) expression is increased in livers of patients with nonalcoholic steatohepatitis and in murine models of steatohepatitis. Several studies in rodents indicate that MCP-1 contributes to liver steatosis induced by feeding a high-fat diet. However, the...
- Cardiovascular changes in patients with adult-onset growth hormone deficiency assessed by CMR. Dattani, Abhishek; Thomas, Julia; Zemrak, Filip; Burchell, Thomas R.; Petersen, Steffen E.; Grossman, Ashley; Korbonits, Marta; Davies, Ceri // Journal of Cardiovascular Magnetic Resonance (BioMed Central);2012 Supplement, Vol. 14 Issue Suppl 1, p1
An abstract of the article "Cardiovascular changes in patients with adult-onset growth hormone deficiency assessed by CMR," by Abhishek Dattani and colleagues is presented.
- Sorafenib. // Reactions Weekly;Jul2015, Vol. 1561 Issue 1, p162
An abstract of the article "Fulminant hepatitis in a patient with hepatocellular carcinoma related to nonalcoholic steatohepatitis treated with sorafenib," by G. Brandi and colleagues is presented.
- Increased Thickness of Abdominal Subcutaneous Adipose Tissue Occurs More Frequently in Steatohepatitis Than in Simple Steatosis. Fiel, M. Isabel; Reza Sima, Hamid; Desman, Garrett; Azarian, Amirabbas; Lento, Patrick; Schiano, Thomas D. // Archives of Pathology & Laboratory Medicine;May2013, Vol. 137 Issue 5, p642
Context.-The incidence of obesity is increasing and contributes to the rising incidence of fatty liver. Body mass index (BMI) is used to assess the degree of obesity but does not take into account the pattern of body fat distribution. Objectives.-To confirm the increasing incidence of fatty...
- Controversy about Treatment of Growth Hormone-Deficient Adults: A Commentary. Frohman, Lawrence A. // Annals of Internal Medicine;8/6/2002, Vol. 137 Issue 3, p202
Editorial. Comments on the controversy about the treatment of growth hormone deficiency in adults. Complexity of the diagnosis and therapy of patients with growth hormone deficiency; Degrees of growth hormone deficiency.
- High-sensitivity C-reactive protein and metabolic syndrome (insulin resistance syndrome), including nonalcoholic steatohepatitis. Oda, Eiji; Watanabe, Kenichi // Journal of Gastroenterology;2008, Vol. 43 Issue 4, p312
A letter to the editor is presented in response to the Yoneda et al report on high-sensitivity C-reactive protein (CRP) as an independent marker in non-alcoholic steatohepatitis (NASH) from nonprogressive hepatic steatosis.
- A Role for Low Hepatic Copper Concentrations in Nonalcoholic Fatty Liver Disease. Aigner, Elmar; Strasser, Michael; Haufe, Heike; Sonnweber, Thomas; Hohla, Florian; Stadlmayr, Andreas; Solioz, Marc; Tilg, Herbert; Patsch, Wolfgang; Weiss, Guenter; Stickel, Felix; Datz, Christian // American Journal of Gastroenterology;Sep2010, Vol. 105 Issue 9, p1978
OBJECTIVES:Copper has a role in antioxidant defense, lipid peroxidation, and mitochondrial function, and copper deficiency has been linked to atherogenic dyslipidemia. We aimed to investigate the potential role of copper availability in the pathogenesis of nonalcoholic fatty liver disease...
- NLRP3 inflammasome activation is required for fibrosis development in NAFLD. Wree, Alexander; McGeough, Matthew; Peña, Carla; Schlattjan, Martin; Li, Hongying; Inzaugarat, Maria; Messer, Karen; Canbay, Ali; Hoffman, Hal; Feldstein, Ariel // Journal of Molecular Medicine;Oct2014, Vol. 92 Issue 10, p1069
NLR inflammasomes, caspase 1 activation platforms critical for processing key pro-inflammatory cytokines, have been implicated in the development of nonalcoholic fatty liver disease (NAFLD). As the direct role of the NLRP3 inflammasome remains unclear, we tested effects of persistent NLRP3...
- Prolonged hepatitis caused by cytomegalovirus and non-alcoholic steatohepatitis in 16-year-old obese boy. Kanda, Tatsuo; Yokosuka, Osamu; Suzuki, Yutaka // European Journal of Pediatrics;Apr2005, Vol. 164 Issue 4, p212
Recently, the prevalence of non-alcoholic steatohepatitis (NASH) has been increasingly reported in patients with type 2 diabetes and obesity. NASH exists not only in adults but also in children. We report on an 16-year-old boy with prolonged hepatitis associated with NASH after cytomegalovirus...
- KÃ¶tÃ¼ KontrollÃ¼ Tip 1 Diabetes Mellitusa EÅŸlik Eden Muhtemel Bir Hepatik Glikojenozis VakasÄ±. Kılıç Kan, Elif; Cengiz Ecemiş, Gülçin; Tura Bahadır, Çiğdem; Atmaca, Hulusi; Çolak, Ramis; Atmaca, Ayşegül // Turkish Journal of Endocrinology & Metabolism;Dec2012, Vol. 16 Issue 4, p79
The major causes of hepatomegaly and elevated transaminases in patients with diabetes mellitus are glycogenosis or fatty liver and nonalcoholic steatohepatitis (NASH). Although hepatic glycogenosis is common in this population, hepatomegaly or elevated transaminase are more often attributed to...