Incidence of gastroduodenal ulcers in patients with rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or placebo: a multicentre, randomised, double blind study

Hawkey, C. J.; Laine, L.; Simon, T; Quan, H.; Shingo, S.; Evans, J.
June 2003
Gut;Jun2003, Vol. 52 Issue 6, p820
Academic Journal
No abstract available.


Related Articles

  • Minerva.  // BMJ: British Medical Journal (International Edition);6/7/2003, Vol. 326 Issue 7401, p1274 

    A man without qualifications worked for 18 months as a senior clinical scientist before being found guilty of defrauding the NHS. Despite the availability of a safe, highly effective, and inexpensive vaccine, measles affects more than 30 million children and claims the lives of almost 750 000...

  • Celecoxib: A Review of its Use in Osteoarthritis, Rheumatoid Arthritis and Acute Pain. Clemett, D.; Goa, K.L. // Drugs;Apr2000, Vol. 59 Issue 4, p957 

    Celecoxib is a cyclo-oxygenase (COX) inhibitor that exhibits relative in vitro and ex vivo selectivity for COX-2 over COX-1. Results of randomised double-blind multicentre studies indicate that celecoxib is superior to placebo and has similar efficacy as conventional nonsteroidal...

  • Rofecoxib: A Review of its Use in the Management of Osteoarthritis, Acute Pain and Rheumatoid Arthritis. Matheson, A.J.; Figgitt, D.P. // Drugs;Apr2001, Vol. 61 Issue 6, p833 

    Rofecoxib is a selective cyclo-oxygenase (COX)-2 inhibitor which has little or no effect on the COX-1 isoenzyme at doses up to 1000 mg/day. Rofecoxib has greater selectivity for COX-2 than celecoxib, meloxicam, diclofenac and indomethacin. In well-controlled clinical trials, rofecoxib 12.5 to...

  • Valdecoxib. Ormrod, D.; Wellington, K.; Wagstaff, A.J. // Drugs;2002, Vol. 62 Issue 14, p2059 

    â–´ In ten large, well-controlled, randomised trials (n = 203 to 1089), valdecoxib, a selective inhibitor of cyclo-oxygenase-2, was significantly more effective than placebo in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with primary dysmenorrhoea, and for...

  • Naproxen in Rheumatoid Arthritis. Bowers, Donn E.; Dyer, Herbert R.; Fosdick, William M.; Keller, Karl E.; Rosenberg, Alan L.; Sussman, Paul; Vancil, Martin E. // Annals of Internal Medicine;Oct75, Vol. 83 Issue 4, p470 

    Evaluates the efficacy of naproxen in treating rheumatoid arthritis patients in a double-blind clinical trial using aspirin as the control drug. Background of rheumatoid arthritis; Information on naproxen; Assessment scores during trial for those patients completing the study; Incidence of side...

  • Reduced Incidence of Gastroduodenal Ulcers With Celecoxib, a Novel Cyclooxygenase-2 Inhibitor, Compared to Naproxen in Patients With Arthritis. Goldstein, J. L.; Correa, P.; Zhao, W. W.; Burr, A. M.; Hubbard, R. C.; Verburg, K. M.; Geis, G. S. // American Journal of Gastroenterology;Apr2001, Vol. 96 Issue 4, p1019 

    OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) block prostaglandin production by inhibiting cyclooxygenase (COX); they are believed to cause gastroduodenal dam-age by inhibiting the COX-1 isoform and to have analgesic and anti-inflammatory effects by inhibiting the COX-2 isoform. As...

  • Rofecoxib. Scott, L.J.; Lamb, H.M. // Drugs;Sep1999, Vol. 58 Issue 3, p499 

    â–´ Rofecoxib selectively inhibits cyclo-oxygenase-2 in a dose-dependent manner in humans. No significant inhibition of cyclo-oxygenase-1 is observed with rofecoxib up to doses of 1000mg. â–´ In 4 large double-blind randomised trials performed in patients with osteoarthritis, rofecoxib...

  • Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis. Simmons, Lee S.; Weaver, Arthur L. // JAMA: Journal of the American Medical Association;11/24/99, Vol. 282 Issue 20, p1921 

    Reports on the anti-inflammatory and upper gastrointestinal effects of the nonsteroidal anti-inflammatory drug celecoxib in the treatment of rheumatoid arthritis. Comparison with a placebo and naproxen; Treatment time for maximal anti-inflammatory and analgesic activity; Incidence of...

  • Aspirin + celecoxib easier to stomach than aspirin + naproxen.  // Reactions Weekly;7/15/2006, Issue 1110, p1 

    This article presents the results of a randomized, double-blind, multicentre study which compares the impact of the administration of celecoxib plus aspirin with naproxen plus aspirin in lowering incidence of endoscopic gastric and duodenal ulcers. The incidence of endoscopic gastric and...

  • A Prospective Randomized Study of the Injurious Effects of Aspirin and Naproxen on the Gastroduodenal Mucosa in Patients with Rheumatoid Arthritis. Mehta, S.; Dasarathy, S.; Tandon, R. K.; Mathur, M.; Malaviya, A. N. // American Journal of Gastroenterology;Aug1992, Vol. 87 Issue 8, p996 

    A prospective double-blind randomized placebo-controlled study was conducted to compare the injurious effects of aspirin and naproxen on the gastroduodenal mucosa. Patients with rheumatoid arthritis attending the immunology clinic of a tertiary care center were included in the study. Ninety...


Read the Article


Sign out of this library

Other Topics