Lipoxin A4: a novel anti-inflammatory molecule?

Lee, T H
February 1995
Thorax;Feb1995, Vol. 50 Issue 2, p111
Academic Journal
No abstract available.


Related Articles

  • PERSPECTIVES IN BASIC SCIENCE Lipoxins: Potential anti-inflammatory, proresolution, and antifibrotic mediators in renal disease. Kieran, Niamh E.; Maderna, Paola; Godson, Catherine // Kidney International;Apr2004, Vol. 65 Issue 4, p1145 

    Lipoxins: Potential anti-inflammatory, proresolution, and antifibrotic mediators in renal disease. Lipoxins are lipoxygenase-derived lipid mediators with both anti-inflammatory and proresolution properties that have been demonstrated in vivo and in vitro. The bioactivity profile of lipoxins in...

  • LIPOXINS IN CHRONIC INFLAMMATION. Kantarci, Alpdogan; Van Dyke, Thomas E. // Critical Reviews in Oral Biology & Medicine;Jan2003, Vol. 14 Issue 1, p4 

    The discovery of endogenous molecules involved in counterregulation of inflammatory responses that may lead to tissue injury provides an opportunity to explore new therapeutic approaches based on manipulation of new pathways. Natural counterregulatory pathways may reduce the possibility of...

  • An oily, sustained counter-regulatory response to TB. Karp, Christopher L.; Cooper, Andrea M. // Journal of Clinical Investigation;Jun2005, Vol. 115 Issue 6, p1473 

    Lipoxins are potent antiinflammatory lipid mediators that restrain and promote the resolution of a wide variety of inflammatory processes. Recent studies implicating deficient lipoxin production in the pathogenesis of diverse inflammatory diseases, along with numerous reports of the beneficial...

  • Regulation of Inflammation: A Review of Recent Advances in Anti- Inflammatory Strategies. Brenner, P.S.; Krakauer, T. // Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy A;Sep2003, Vol. 2 Issue 3, p274 

    Many chronic debilitating diseases result from uncontrolled inflammation. Inflammatory cells, such as neutrophils, eosinophils, basophils, mast cells, macrophages, endothelial cells, and platelets, respond to inflammatory stimuli and foreign substances by producing bioactive mediators, such as...

  • A defect in Δ6 and Δ5 desaturases may be a factor in the initiation and progression of insulin resistance, the metabolic syndrome and ischemic heart disease in South Asians. Das, Undurti N. // Lipids in Health & Disease;2010, Vol. 9, p130 

    The high incidence of insulin resistance and the metabolic syndrome in South Asians remains unexplained. I propose that a defect in the activity of Δ6 and Δ5 desaturases and consequent low plasma and tissue concentrations of polyunsaturated fatty acids such as g-linolenic acid (GLA),...

  • Leukocyte adhesion promotes biosynthesis of lipoxygenase products by transcellular routes. Brady, Hugh R.; Papayianni, Aikaterina; Serhan, Charles N. // Kidney International Supplement;Feb1994, Issue 45, pS-90 

    Discusses the potential trance pathways for leukotriene and lipoxin generation in glomerulonephritis. Role of adhesion molecules in the recruitment of circulating leukocytes to sites of inflammation; Elucidation of the interplay between leukocyte adhesion and transcellular biosynthetic pathways;...

  • Novel Biphasic Role of LipoxinA4 on Expression of Cyclooxygenase-2 in Lipopolysaccharide-Stimulated Lung Fibroblasts. Shengxing Zheng; Qian Wang; Qian He; Xiaorong Song; Duyun Ye; Fang Gao; Shengwei Jin; QingQuan Lian // Mediators of Inflammation;2011, Vol. 2011, Special section p1 

    Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation. We investigated the effect of lipoxinA4 on the expression of cyclooxygenase-2 in...

  • Lipoxins as biomarkers of lupus and other inflammatory conditions. Das, Undurti N. // Lipids in Health & Disease;2011, Vol. 10 Issue 1, p76 

    Inflammatory events persist in systemic lupus erythematosus (lupus) despite the use of anti-inflammatory (both steroidal and non-steroidal) and immunosuppressive drugs leading to delay in the healing/repair process and so tissue/organ damage continues. The continuation of inflammation in lupus...

  • Nitric Oxide, Aspirin-Triggered Lipoxins and NO-Aspirin in Gastric Protection. Wallace, John L. // Inflammation & Allergy - Drug Targets;Apr2006, Vol. 5 Issue 2, p133 

    The use of nonsteroidal anti-inflammatory drugs is associated with an incidence of severe gastrointestinal adverse events of 2-4%, the most common of which is bleeding. These events are largely attributable to the ability of these drugs to suppress prostaglandin and thromboxane synthesis....

  • G protein-coupled receptors: An endogenous allosteric cannabinoid modulator. Harrison, Charlotte // Nature Reviews Drug Discovery;Jan2013, Vol. 12 Issue 1, p24 

    The article discusses lipoxin A4, which references the study "Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor," by F. A. Pamplona and colleagues in the November 12, 2012 issue of the periodical "Proceedings of the National Academy of Sciences."


Read the Article


Sign out of this library

Other Topics