Effect of fluticasone propionate on neutrophil chemotaxis, superoxide generation, and extracellular proteolytic activity in vitro

Llewellyn-Jones, C G; Hill, S L; Stockley, R A
March 1994
Thorax;Mar1994, Vol. 49 Issue 3, p207
Academic Journal
No abstract available.


Related Articles

  • Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils. Jen-pei LEE; Yi-ching LI; Hung-yi CHEN; Ruey-hseng LIN; Shiang-suo HUANG; Hui-ling CHEN; Pai-chuan KUAN; Mao-fang LIAO; Chun-jung CHEN; Yu-hsiang KUAN // Acta Pharmacologica Sinica;Jul2010, Vol. 31 Issue 7, p831 

    AbstractAim:To investigate whether luteolin, the major polyphenolic components of Lonicera japonica, has beneficial effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) and to determine whether the protective mechanism involves anti-inflammatory effects on...

  • The Effects of Bruton Tyrosine Kinase Inhibition on Chemotaxis and Superoxide Generation in Human Neutrophils. Broides, Arnon; Hadad, Nurit; Levy, Jacov; Levy, Rachel // Journal of Clinical Immunology;Jul2014, Vol. 34 Issue 5, p555 

    Purpose: The role of the Bruton tyrosine kinase (Btk) protein in neutrophil function has been evaluated using neutrophils from healthy volunteers after incubation with a Btk inhibitor, leflunomide metabolite analog (LFM-A13), suggesting an important role for Btk in neutrophil function. We sought...

  • Salmeterol/Fluticasone Propionate. McKeage, Kate; Keam, Susan J. // Drugs;2009, Vol. 69 Issue 13, p1799 

    Salmeterol/fluticasone propionate (Seretide/Advair Diskus® [dry powder inhaler] or Seretide/Advair® inhalation aerosol [metered-dose inhaler]) is a fixed-dose combination inhalation agent containing a long-acting b2-adrenoceptor agonist (LABA) plus a corticosteroid. In patients with...

  • PDK1 Regulates Chemotaxis in Human Neutrophils. Yagi, M.; Kantarci, A.; Iwata, T.; Omori, K.; Ayilavarapu, S.; Ito, K.; Hasturk, H.; Van Dyke, T. E. // Journal of Dental Research;Dec2009, Vol. 88 Issue 12, p1119 

    Phosphoinositide-dependent kinase (PDK1) plays a central role in signal transduction mediated by phosphatidylinositol 3-kinases (PI3K) and regulates cellular functions in neutrophils. Neutrophils from individuals diagnosed with localized aggressive periodontitis (LAP) present an in vivo...

  • Effect of verocytotoxins (Shiga-like toxins) on human neutrophils in vitro. Holle, Julie U.; Williams, Julie M.; Harper, Lorraine; Savage, Caroline O.; C. Mark; Taylor // Pediatric Nephrology;Sep2005, Vol. 20 Issue 9, p1237 

    Neutrophil activation occurs in diarrhoea-associated HUS and correlates with disease severity, implying a role in pathogenesis. Verocytotoxin (Shiga-like toxin) has been shown to stimulate endothelium to release chemokines and express leukocyte adhesion molecules that would lead to indirect...

  • A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Weathington, Nathaniel M.; van Houwelingen, Anneke H.; Noerager, Brett D.; Jackson, Patricia L.; Kraneveld, Aletta D.; Galin, F. Shawn; Folkerts, Gert; Nijkamp, Frans P.; Blalock, J. Edwin // Nature Medicine;Mar2006, Vol. 12 Issue 3, p317 

    We describe the tripeptide neutrophil chemoattractant N-acetyl Pro-Gly-Pro (PGP), derived from the breakdown of extracellular matrix (ECM), which shares sequence and structural homology with an important domain on alpha chemokines. PGP caused chemotaxis and production of superoxide through CXC...

  • Pharmacological Studies on the Anti-inflammatory Action of Phenolic Compounds. AZUMA, Y.; OZASA, N.; UEDA, Y.; TAKAGI, N. // Journal of Dental Research;Jan1986, Vol. 65 Issue 1, p53 

    The mechanism of the anti-inflammatory action of phenolic compounds was examined using neutrophil chemotaxis. Chemotactic activity of guinea pig peritoneal neutrophils to N-formylmethionyl-leucyl-phenylalanine (FMLP) was suppressed in a concentration-dependent manner. The order of drug potency...

  • Assessment of peripheral neutrophil functions in patients with localized aggressive periodontitis in the Indian population. Bhansali, Rahul S.; Yeltiwar, R. K.; Bhat, K. G. // Journal of Indian Society of Periodontology;Nov/Dec2013, Vol. 18 Issue 6, p731 

    Background: Localized aggressive periodontitis (LAP) patients exhibit abnormal neutrophil functions to a variety of environmental and host stimuli. The aim of the present study was to evaluate neutrophils chemotaxis, phagocytosis, microbicidal activity and superoxide generation in LAP patients...

  • Lucigenin- and Luminol-Dependent Chemiluminescence of Blood Neutrophils in Patients with Renal Cancer. Shkapova, E.; Kurtasova, L.; Savchenko, A. // Bulletin of Experimental Biology & Medicine;Feb2010, Vol. 149 Issue 2, p239 

    High basal production of primary active oxygen forms was detected in the peripheral blood neutrophils of patients with renal cell cancer. In vitro stimulation of neutrophils led to more rapid release of superoxide radicals into extracellular space and to a reduction of cell capacity to more...

  • Thymosin β 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids. Young, J.D.; Lawrence, A.J.; MacLean, A.G.; Leung, B.P.; McInnes, I.B.; Canas, B.; Pappin, D.J.C.; Stevenson, R.D. // Nature Medicine;Dec99, Vol. 5 Issue 12, p1424 

    The possibility that glucocorticoids upregulate the expression of anti-inflammatory mediators is an exciting prospect for therapy in inflammatory diseases, because these molecules could give the therapeutic benefits of steroids without toxic side effects. Supernatants from monocytes and...


Read the Article


Sign out of this library

Other Topics