Inhibition of microvascular endothelial cell proliferation by vitreous following retinal scatter photocoagulation

Singh, A; Boulton, M; Lane, C; Forrester, J; Gaal, J; McLeod, D
June 1990
British Journal of Ophthalmology;Jun1990, Vol. 74 Issue 6, p328
Academic Journal
No abstract available.


Related Articles

  • Increased Vitreous Shedding of Microparticles in Proliferative Diabetic Retinopathy Stimulates Endothelial Proliferation. Chahed, Sadri; Leroyer, Aurélie S.; Benzerroug, Mounir; Gaucher, David; Georgescu, Adriana; Picaud, Serge; Silvestre, Jean-Sébastien; Gaudric, Alain; Tedgui, Alain; Massin, Pascale; Boulanger, Chantal M. // Diabetes;Mar2010, Vol. 59 Issue 3, p694 

    OBJECTIVE--Diabetic retinopathy is associated with progressive retinal capillary activation and proliferation, leading to vision impairment and blindness. Microparticles are submicron membrane vesicles with biological activities, released following cell activation or apoptosis. We tested the...

  • Diabetic Retinopathy at the Molecular and Cellular Level.  // Ophthalmology Times;4/1/2005 Supplement 5, Vol. 30, p5 

    Presents two physicians' views on diabetic retinopathy at the molecular and cellular level. Effect of diabetes-induced high glucose concentrations on the pericyte cells of retinal capillaries; Effect of laser pan-retinal photocoagulation on vascular endothelial growth factor levels in the...

  • KLF4 Promotes Angiogenesis by Activating VEGF Signaling in Human Retinal Microvascular Endothelial Cells. Wang, Yinan; Yang, Chuanhe; Gu, Qingqing; Sims, Michelle; Gu, Weiwang; Pfeffer, Lawrence M.; Yue, Junming // PLoS ONE;Jun2015, Vol. 10 Issue 6, p1 

    The transcription factor Krüppel-like factor 4 (KLF4) has been implicated in regulating cell proliferation, migration and differentiation in a variety of human cells and is one of four factors required for the induction of pluripotent stem cell reprogramming. However, its role has not been...

  • Investigating the Global Dispersal of Chickens in Prehistory Using Ancient Mitochondrial DNA Signatures. Storey, Alice A.; Stephen Athens, J.; Bryant, David; Carson, Mike; Emery, Kitty; DeFrance, Susan; Higham, Charles; Huynen, Leon; Intoh, Michiko; Jones, Sharyn; Kirch, Patrick V.; Ladefoged, Thegn; McCoy, Patrick; Morales-Muñiz, Arturo; Quiroz, Daniel; Reitz, Elizabeth; Robins, Judith; Walter, Richard; Matisoo-Smith, Elizabeth // PLoS ONE;Jul2012, Vol. 7 Issue 7, p1 

    Retinal neovascularization is a critical component in the pathogenesis of common ocular disorders that cause blindness, and treatment options are limited. We evaluated the therapeutic effect of a DNA enzyme targeting c-jun mRNA in mice with preexisting retinal neovascularization. A single...

  • Erythropoietin as a Retinal Angiogenic Factor in Proliferative Diabetic Retinopathy. Watanabe, Daisuke; Suzuma, Kiyoshi; Matsui, Shigeyuki; Kurimoto, Masafumi; Kiryu, Junichi; Kita, Mihori; Suzuma, Izumi; Ohashi, Hirokazu; Ojima, Tomonari; Murakami, Tomoaki; Kobayashi, Toshihiro; Masuda, Seiji; Nagao, Masaya; Yoshimura, Nagahisa; Takagi, Hitoshi // New England Journal of Medicine;8/25/2005, Vol. 353 Issue 8, p782 

    Background: Although vascular endothelial growth factor (VEGF) is a primary mediator of retinal angiogenesis, VEGF inhibition alone is insufficient to prevent retinal neovascularization. Hence, it is postulated that there are other potent ischemia-induced angiogenic factors. Erythropoietin...

  • Management of Diabetic Retinopathy: An Overview. Boniuk, Isaac // Angiology;Jul1980, Vol. 31 Issue 7, p462 

    This article focuses on the management of diabetic retinopathy. Diabetic retinopathy can occur in three stages: nonproliferative, proliferative, or vitreous contracture. The background or nonproliferative stage is characterized by microaneurysms, retinal edema, hard exudates, retinal...

  • Recombinant α2(IV)NC1 domain of type IV collagen is an effective regulator of retinal capillary endothelial cell proliferation and inhibits pre-retinal neovascularisation. Gary Coleman; Tom Gardiner; Ariel Boutaud; Alan Stitt // Graefe's Archive of Clinical & Experimental Ophthalmology;Apr2007, Vol. 245 Issue 4, p581 

    AbstractBackground  A recombinant form of the α2(IV)NC1 domain of type IV collagen has been shown to have potent anti-angiogenic activity although this peptide has not been studied in the context of proliferative retinopathies. In the current investigation we examined the potential for...

  • (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy. Kanda, A.; Noda, K.; Saito, W.; Ishida, S. // Diabetologia;Nov2012, Vol. 55 Issue 11, p3104 

    Aims/hypothesis: The renin-angiotensin system (RAS) potentially has a role in the development of end-organ damage, and tissue RAS activation has been suggested as a risk factor for diabetic retinopathy. We have recently shown significant involvement of (pro)renin receptor ([P]RR) in retinal...

  • Basic Fibroblast Growth Factor Contributes to a Shift in the Angioregulatory Activity of Retinal Glial (Müller) Cells. Yafai, Yousef; Iandiev, Ianors; Lange, Johannes; Yang, Xiu Mei; Wiedemann, Peter; Bringmann, Andreas; Eichler, Wolfram // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    Basic fibroblast growth factor (bFGF) is a pleiotropic cytokine with pro-angiogenic and neurotrophic effects. The angioregulatory role of this molecule may become especially significant in retinal neovascularization, which is a hallmark of a number of ischemic eye diseases. This study was...

  • Role of Vascular Endothelial Growth Factor in the Breakdown of the Blood-Aqueous Barrier After Retinal Laser Photocoagulation in Pigmented Rabbits. Chen, Muh-Shy; Chang, Ching-Chung; Lin, Chang-Ping; Wang, Peng-Chen; Lin, Li-Rong; Hou, Ping-Kang; Ho, Tzyy-Chang // Journal of Ocular Pharmacology & Therapeutics;Feb2012, Vol. 28 Issue 1, p83 

    Purpose: Retinal laser photocoagulation is used to treat a variety of retinal diseases. Breakdown of the blood-aqueous barrier has been noted after retinal laser photocoagulation. The effect of vascular endothelial growth factor (VEGF) on the function of the blood-aqueous barrier after retinal...


Read the Article


Sign out of this library

Other Topics