TITLE

Assessment of antemortem tests used in the control of an outbreak of tuberculosis in llamas (Lama glama)

AUTHOR(S)
Twomey, D. F.; Crawshaw, T. R.; Anscombe, J. E.; Barnett, J. E. F.; Farrant, L.; Evans, L. J.; McElligott, W. S.; Higgins, R. J.; Dean, G. S.; Vordermeier, H. M.; de la Rua-Domenech, R.
PUB. DATE
September 2010
SOURCE
Veterinary Record: Journal of the British Veterinary Association;Sep2010, Vol. 167 Issue 13, p475
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An outbreak of tuberculosis (TB) caused by in a llama herd is described. Over a 25-month period, a total of 70 llamas were selected for postmortem examination using four distinct criteria: clinical suspicion of disease (15 animals), positive tuberculin skin test result (three animals), antibody positive using a novel serological test (Rapid Test, 54 animals) and elective cull (five animals). Some animals qualified on more than one criterion. Gross lesions of TB were detected in 15 animals, with lung and lymph node lesions consistently observed. Samples were collected from 14 of 15 animals with visible lesions as well as those with no visible lesions, for histopathology and mycobacterial culture. All 14 llamas with visible lesions had caseonecrotic granulomatous lesions associated with acid-fast bacteria and variable mineralisation, and was isolated from 13. There were no histopathological lesions of TB in llamas with no grossly visible lesions, and was not isolated from any of these. The predictive value of suspicious gross lesions at postmortem examination was therefore high in the herd. Molecular typing results indicated that the outbreak was caused by a single strain likely to have originated from a local reservoir, probably cattle or wildlife. Antemortem indicators of infection assisted control of the outbreak, but no single test accurately identified all TB cases. Visible lesions were detected in nine of 15 llamas with clinical suspicion of disease, in two of three that had positive tuberculin skin test results and in 10 of 54 that were antibody positive; there was none (zero out of five) in llamas that were electively culled.
ACCESSION #
66092085

 

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