Hyperfibrinolysis during intracranial surgery: effect of high dose aprotinin

Palmer, J D; Francis, D A; Roath, O S; Francis, J L; Iannotti, F
January 1995
Journal of Neurology, Neurosurgery & Psychiatry;Jan1995, Vol. 58 Issue 1, p104
Academic Journal
journal article
No abstract available.


Related Articles

  • EVIDENCE-BASED REVIEW OF THE ROLE OF APROTININ IN BLOOD CONSERVATION DURING ORTHOPAEDIC SURGERY. Kokoszka, Agnieszka; Kuflik, Paul; Bitan, Fabien; Casden, Andrew; Neuwirth, Michael // Journal of Bone & Joint Surgery, American Volume;May2005, Vol. 87-A Issue 5, p1129 

    Investigates the role of aprotinin in blood conservation during orthopedic surgery through evidence-based medicine. Characteristics of aprotinin; Capability of aprotinin to reduce blood loss as well as transfusion requirements during hip, knee, and spine surgery; Need for high-quality randomized...

  • Topical application of aprotinin in cardiac surgery. Isgro, Frank; Stanisch, Oliver; Kiessling, Arndt-H; G├╝rler, Semih; Hellstern, Peter; Saggau, Werner // Perfusion;Sep2002, Vol. 17 Issue 5, p347 

    The aim of our study was to compare a systemic and a local aprotinin application in patients during coronary artery bypass graft (CABG) surgery. The advantage of a topical aprotinin application is seen in the fact that this may not lead to systemic side effects. A prospective, randomized study...

  • Antifibrinolytics in liver surgery. Makwana, Jalpa; Paranjape, Saloni; Goswami, Jyotsna // Indian Journal of Anaesthesia;Nov/Dec2010, Vol. 54 Issue 6, p489 

    Hyperfibrinolysis, a known complication of liver surgery and orthotopic liver transplantation (OLT), plays a significant role in blood loss. This fact justifies the use of antifibrinolytic drugs during these procedures. Two groups of drug namely lysine analogues [epsilon aminocaproic acid (EACA)...

  • Perioperative Safety of Aprotinin in Coronary Artery Bypass Graft Surgery. Augoustides, John G. // Drug Safety;2008, Vol. 31 Issue 7, p557 

    The article discusses the perioperative safety of Aprotinin in Coronary Artery Bypass Graft Surgery (CABG). It says that propensity-adjusted multivariate analysis demonstrated that the adverse outcomes after CABG were not only significantly associated with aprotinin exposure but also that they...

  • Aprotinin: An Update of its Pharmacology and Therapeutic Use in Open Heart Surgery and Coronary Artery Bypass Surgery. Peters, D.C.; Noble, S. // Drugs;Feb1999, Vol. 57 Issue 2, p233 

    Cardiopulmonary bypass (CPB) is associated with defective haemostasis which results in bleeding and the requirement for allogenic blood product transfusions in many patients undergoing open heart surgery (OHS) and/or coronary artery bypass graft surgery (CABG) with CPB. Conservation of blood has...

  • Re-Evaluation of the Role of Antifibrinolytic Therapy with Lysine Analogs in Liver Transplantation in The Post-Aprotinin Era. Lucci, F.; Dauri, M.; Mallett, S. V.; Freeman, J. W.; Coniglione, F.; Fabbi, E.; Puliti, R.; Giuliano, I.; Manzia, T. M.; Tisone, G. // Journal of Anesthesia & Clinical Research;Special2012, Vol. 3 Issue S, Special section p1 

    Purpose of review: Hemorrhage, blood and blood product transfusions and the need for surgical re-exploration for bleeding can have a detrimental effect on patient outcome during liver surgery. Following the suspension of aprotinin from the market only the antifibrinolytics tranexamic acid (TA)...

  • Antifibrinolytics in cardiac surgery. Dhir, Achal // Annals of Cardiac Anaesthesia;Apr-Jun2013, Vol. 16 Issue 2, p117 

    Cardiac surgery exerts a significant strain on the blood bank services and is a model example in which a multi-modal blood-conservation strategy is recommended. Significant bleeding during cardiac surgery, enough to cause re-exploration and/or blood transfusion, increases morbidity and...

  • Review and application of serine protease inhibition in coronary artery bypass graft surgery. Engles, Laura // American Journal of Health-System Pharmacy;9/15/2005 Supplement 4, Vol. 62, pS9 

    Purpose. Current pharmacologic agents, aprotinin, epsilon aminocaproic acid, and tranexamic acid, used to decrease blood loss and transfusion requirements during coronary artery bypass graft (CABG) surgery are discussed. Aprotinin is the only agent that also modulates the systemic inflammatory...

  • The Value of Phase 4 Clinical Testing. Vlahakes, Gus J. // New England Journal of Medicine;1/26/2006, Vol. 354 Issue 4, p413 

    This article discusses a study of the limiting of blood loss in patients undergoing cardiac surgery using aprotinin. Cost and potential risks are two reasons why aprotinin is not used in all patients. Higher doses may be required to modulate systemic inflammatory response associated with cardiac...

  • Low dose aprotinin increases mortality and morbidity in coronary artery bypass surgery. Sabzi, Feridoun; Moradi, Gholam Reza; Dadkhah, Heidar; Poormotaabed, Alireza; Dabiri, Samsam // Journal of Research in Medical Sciences;Jan2012, Vol. 17 Issue 1, p74 

    BACKGROUND: The low dose aprotinin consistently reduces blood and transfusion requirement in adults during cardiac surgical procedures but its effectiveness in some ethnical groups were debated and controversy about its effect on mortality and morbidity precludes its routine use. This study was...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics