TITLE

Recent advances in somatic gene therapy for hereditary respiratory diseases

AUTHOR(S)
Owen, C A
PUB. DATE
April 1992
SOURCE
Thorax;Apr1992, Vol. 47 Issue 4, p315
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
66073643

 

Related Articles

  • Gene Therapy for Lung Diseases Development in the Vector Biology and Novel Concepts for Gene Therapy Applications. Suzuki, M.; Matsuse, T.; Isigatsubo, Y. // Current Molecular Medicine;Mar2001, Vol. 1 Issue 1, p67 

    The lung represents an attractive target organ for somatic gene therapy strategy in that, (1) it is easily accessible by vectors, (2) most frequent hereditary disorders, cystic fibrosis (CF) and alpha1-antitrypsin deficiency (alpha1AT), occur in the lung, and (3) carcinoma of the lung is...

  • Is Genie Having a Cure for Oral Cancer - Genetic Dentistry. Lakshman, Anusha Rangare; Deepak, R. S.; Karthik, R. S.; Lakshman, Shruthi Rangare; Lakshman, Amithash Rangare; Ashwini, G. S.; Anushree, M.; Hanchate, Lalith // Journal of Marmara University Institute of Health Sciences;2013, Vol. 3 Issue 4, p215 

    Worldwide, oral carcinoma is one of the most prevalent cancers and it is the sixth most common cancer globally. Oral cancer is associated with genetic mutations which occur due to the exposure to tobacco, alcohol, betel quid. Advances over recent decades in the surgical, radiotherapeutic and...

  • Proximal spinal muscular atrophy: current orthopedic perspective. Haaker, Gerrit; Fujak, Albert // Application of Clinical Genetics;2013, Vol. 6, p113 

    Spinal muscular atrophy (SMA) is a hereditary neuromuscular disease of lower motor neurons that is caused by a defective "survival motor neuron" (SMN) protein that is mainly associated with proximal progressive muscle weakness and atrophy. Although SMA involves a wide range of disease severity...

  • Gene Therapy Fulfilling Its Promise. Kohn, Donald B.; Candotti, Fabio // New England Journal of Medicine;1/29/2009, Vol. 360 Issue 5, p518 

    The authors reflect on gene therapy. They suggest that from its earliest conception, gene therapy was proposed as a therapy that could correct inherited diseases by inserting a normal copy of a relevant gene into somatic cells. They argue that in 2009 the prospects for continuing advancement of...

  • Molecular Pathology of Hereditary and Sporadic Medullary Thyroid Carcinomas. Chernock, Rebecca D.; Hagemann, Ian S. // American Journal of Clinical Pathology;2015, Vol. 143 Issue 6, p768 

    Objectives: Medullary thyroid carcinoma (MTC) is a relatively uncommon type of thyroid malignancy, with unique histologic features and molecular pathology. It is important to recognize, because its management, which is in part driven by the genetic basis of this disease, is different from...

  • Familial Central Nervous System Tumor Syndromes. Hottinger, Andreas F.; Khakoo, Yasmin; Abrey, Lauren E. // Current Cancer Therapy Reviews;2006, Vol. 2 Issue 4, p281 

    The vast majority of nervous system neoplasms occur sporadically. However, most adult and pediatric tumors have a hereditary equivalent. These hereditary forms are an invaluable resource in the identification of genes that may be important for sporadic tumor development. In recent years there...

  • Natural history of Duchenne muscular dystrophy. KE Qing; ZHANG Li // Chinese Journal of Contemporary Neurology & Neurosurgery;May2015, Vol. 15 Issue 5, p355 

    Duchenne muscular dystrophy (DMD) is X-linked recessive hereditary disease. DMD gene mutations result in dystrophin deficiency, which causes not only muscle movement disorders but also scoliosis, cognitive dysfunction, urinary tract diseases, respiratory diseases and heart diseases. Most...

  • Interventions in the Human Genome: Some Moral and Ethical Considerations. Richter, Gerd; Bacchetta, Matthew D. // Journal of Medicine & Philosophy;May98, Vol. 23 Issue 3, p303 

    In the debate regarding the different possibilities for gene therapy, it is presupposed that the manipulations are limited to the nuclear genome (nDNA). Given recent advances in genetics, mitochondrial genome (mtDNA) and diseases must be considered as well. In this paper, we propose a three...

  • Epidermis: An Attractive Target Tissue for Gene Therapy. Greenhalgh, Pavid A.; Rothnagel, Joseph A.; Roop, Dennis R. // Journal of Investigative Dermatology;Nov94 Supplement, Vol. 103, p63S 

    Important advances have been made within the past several years in understanding diseases at the molecular and cellular levels, which may enable the application of somatic gene therapy to a wide variety of genetic and acquired diseases. The initial clinical trials involving somatic gene therapy...

  • Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes. Landrette, Sean F.; Tian Xu // PLoS Genetics;Jul2011, Vol. 7 Issue 7, Special section p1 

    With recent advances in genomic technologies, candidate human disease genes are being mapped at an accelerated pace. There is a clear need to move forward with genetic tools that can efficiently validate these mutations in vivo. Murine somatic mutagenesis is evolving to fulfill these needs with...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics