Enhanced type III collagen gene expression during bleomycin induced lung fibrosis

Shahzeidi, S; Mulier, B; de Crombrugghe, B; Jeffery, P K; McAnulty, R J; Laurent, G J
June 1993
Thorax;Jun1993, Vol. 48 Issue 6, p622
Academic Journal
journal article
No abstract available.


Related Articles

  • The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells. Mitsuhiro Yamada; Hiroshi Kubo; Chiharu Ota; Toru Takahashi; Yukiko Tando; Takaya Suzuki; Naoya Fujino; Tomonori Makiguchi; Kiyoshi Takagi; Takashi Suzuki; Masakazu Ichinose // Respiratory Research;Sep2013, Vol. 14 Issue 9, p1 

    Background: The excess and persistent accumulation of fibroblasts due to aberrant tissue repair results in fibrotic diseases such as idiopathic pulmonary fibrosis. Recent reports have revealed significant changes in microRNAs during idiopathic pulmonary fibrosis and evidence in support of a role...

  • Fra-1/AP-1 Transcription Factor Negatively Regulates Pulmonary Fibrosis In Vivo. Rajasekaran, Subbiah; Vaz, Michelle; Reddy, Sekhar P. // PLoS ONE;Jul2012, Vol. 7 Issue 7, p1 

    The Fra-1/AP-1 transcription factor plays a key role in tumor epithelial cell progression; however, its role in pathogenic lung fibrosis remains unclear. In the present study, using a genetic approach (Fra-1 deficient mice), we have demonstrated a novel regulatory (protective) role for Fra-1 in...

  • Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents. Dong, Jie; Yu, Xiaoqing; Porter, Dale; Battelli, Lori; Kashon, Michael; Ma, Qiang // Archives of Toxicology;Feb2016, Vol. 90 Issue 2, p385 

    Pulmonary fibrosis results from the excessive deposition of collagen fibers and scarring in the lungs with or without an identifiable cause. The mechanism(s) underlying lung fibrosis development is poorly understood, and effective treatment is lacking. Here we compared mouse lung fibrosis...

  • The In Vivo Fibrotic Role of FIZZ1 in Pulmonary Fibrosis. Liu, Tianju; Yu, Hongfeng; Ullenbruch, Matthew; Jin, Hong; Ito, Toshihiro; Wu, Zhe; Liu, Jianhua; Phan, Sem H. // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    FIZZ (found in inflammatory zone) 1, a member of a cysteine-rich secreted protein family, is highly induced in lung allergic inflammation and bleomycin induced lung fibrosis, and primarily expressed by airway and type II alveolar epithelial cells. This novel mediator is known to stimulate...

  • Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis. Srivastava, Mrigank; Steinwede, Kathrin; Kiviranta, Riku; Morko, Jukka; Hoymann, Heinz-Gerd; Länger, Florian; Buhling, Frank; Welte, Tobias; Maus, Ulrich A. // Respiratory Research;2008, Vol. 9, Special section p1 

    Background: Lung fibrosis is a devastating pulmonary disorder characterized by alveolar epithelial injury, extracellular matrix deposition and scar tissue formation. Due to its potent collagenolytic activity, cathepsin K, a lysosomal cysteine protease is an interesting target molecule with...

  • Role of IGF-1 pathway in lung fibroblast activation. Chi F. Hung; Rohani, Maryam G.; Sung-soon Lee; Peter Chen; Schnapp, Lynn M. // Respiratory Research;Oct2013, Vol. 14 Issue 10, preceding p1 

    Background: IGF-1 is elevated in pulmonary fibrosis and acute lung injury, where fibroblast activation is a prominent feature. We previously demonstrated that blockade of IGF pathway in murine model of lung fibrosis improved outcome and decreased fibrosis. We now expand that study to examine...

  • Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice. Yan Cai; Mitsuhiro Yoneda; Takeshi Tomita; Reiko Kurotani; Minoru Okamoto; Taketomo Kido; Hiroyuki Abe; Mitzner, Wayne; Guha, Arjun; Shioko Kimura // BMC Pulmonary Medicine;Jul2015, Vol. 15 Issue 1, p1 

    Background: Secretoglobin (SCGB) 3A2, a cytokine-like secretory protein of small molecular weight, is predominantly expressed in airway epithelial cells. While SCGB3A2 is known to have anti-inflammatory, growth factor, and anti-fibrotic activities, whether SCGB3A2 has any other roles,...

  • Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury. Failla, Marco; Genovese, Tiziana; Mazzon, Emanuela; Gili, Elisa; Muià, Carmelo; Sortino, Mariangela; Crimi, Nunzio; Caputi, Achille P.; Cuzzocrea, Salvatore; Vancheri, Carlo // Respiratory Research;2006, Vol. 7, p137 

    Leukotrienes are increased locally in idiopathic pulmonary fibrosis. Furthermore, a role for these arachidonic acid metabolites has been thoroughly characterized in the animal bleomycin model of lung fibrosis by using different gene knock-out settings. We investigated the efficacy of...

  • C/EBPβ-Thr217 Phosphorylation Signaling Contributes to the Development of Lung Injury and Fibrosis in Mice. Buck, Martina; Chojkier, Mario // PLoS ONE;2011, Vol. 6 Issue 10, p1 

    Background: Although C/EBPβko mice are refractory to Bleomycin-induced lung fibrosis the molecular mechanisms remain unknown. Here we show that blocking the ribosomal S-6 kinase (RSK) phosphorylation of the CCAAT/Enhancer Binding Protein (C/EBP)-β on Thr217 (a RSK phosphoacceptor) with...

  • Berberine inhibits Smad and non-Smad signaling cascades and enhances autophagy against pulmonary fibrosis. Chitra, Palanivel; Saiprasad, Gowrikumar; Manikandan, Ramar; Sudhandiran, Ganapasam // Journal of Molecular Medicine;Sep2015, Vol. 93 Issue 9, p1015 

    Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative lung disorder of unknown aetiology. Transforming growth factor-β1 (TGF-β1)-mediated Smad and non-Smad signaling cascades are considered as central players in accelerating pulmonary fibrosis. We earlier reported berberine's...


Read the Article


Sign out of this library

Other Topics