Correlation of GM-CSF mRNA in bronchoalveolar fluid with indices of clinical activity in sarcoidosis

Itoh, A; Yamaguchi, E; Furuya, K; Hizawa, N; Ohnuma, N; Kawakami, Y; Kuzumaki, N
December 1993
Thorax;Dec1993, Vol. 48 Issue 12, p1230
Academic Journal
No abstract available.


Related Articles

  • Altered Cyclooxygenase-2 Expression in Pulmonary Sarcoidosis is not Related to Clinical Classifications. Kiszałkiewicz, Justyna; Piotrowski, Wojciech; Pastuszak-Lewandoska, Dorota; Górski, Paweł; Antczak, Adam; Górski, Witold; Domańska-Senderowska, Daria; Migdalska-Sęk, Monika; Czarnecka, Karolina; Nawrot, Ewa; Brzeziańska-Lasota, Ewa // Inflammation;Aug2016, Vol. 39 Issue 4, p1302 

    Elevated COX-2 activity is associated with the development of chronic lung diseases leading to bronchial obstruction, including sarcoidosis. The aim of the study was to examine expression pattern of COX-2 messenger RNA (mRNA). Expression was performed by q-PCR method in bronchoalveolar lavage...

  • Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis. Malur, Anagha; Kavuru, Mani S.; Marshall, Irene; Barna, Barbara P.; Huizar, Isham; Karnekar, Reema; Thomassen, Mary Jane // Respiratory Research;Jun2012, Vol. 13 Issue 6, p1 

    Rationale: Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant...

  • Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes. Dalrymple, Heidi; Barna, Barbara P.; Malur, Anagha; Malur, Achut G.; Kavuru, Mani S.; Thomassen, Mary Jane // BMC Immunology;2013, Vol. 14 Issue 1, p1 

    Background: Activin A is a pleiotrophic regulatory cytokine, the ablation of which is neonatal lethal. Healthy human alveolar macrophages (AMs) constitutively express activin A, but AMs of patients with pulmonary alveolar proteinosis (PAP) are deficient in activin A. PAP is an autoimmune lung...

  • Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis. Idali, Farah; Wahlström, Jan; Dahlberg, Benita; Khademi, Mohsen; Olsson, Tomas; Eklund, Anders; Johan6Grunewald // Respiratory Research;2009, Vol. 10, p1 

    Background: Activated T helper (Th)-1 pulmonary CD4+ cells and their mediators are essential for the inflammation and granulomatous process in sarcoidosis. Recently, T-cell immunoglobulin and mucin domain (TIM) molecules were suggested to be important regulators of immune function. In this...

  • Expression of Cytokine mRNA in Bronchoalveolar Lavage Cells from Atopic Asthmatics before Late Antigen-Induced Reaction. Miadonna, A.; Gibelli, S.; Lorini, M.; Tedeschi, A.; Oddera, S.; Rossi, G.A.; Crimi, E. // Lung;1997, Vol. 175 Issue 3, p195 

    Recently, much attention has been given to the possible role of lymphocytes and their soluble products in causing and maintaining allergic inflammation. The aim of this study was to assess the production of mRNAs for interleukins (IL) in bronchoalveolar lavage (BAL) cells obtained from...

  • Antifibrotic Role of HGF in Sarcoidosis. Faehling, Martin; Hetzel, Martin; Anders, Diana; Trischler, Gerlinde; Bachem, Max // Lung;Jun2012, Vol. 190 Issue 3, p303 

    Background: Pulmonary sarcoidosis has a variable course ranging from self-limiting disease to progressive fibrosis. Activation of fibroblasts, myofibroblast transformation, and matrix production may contribute to pulmonary damage in sarcoidosis. These processes are influenced by pulmonary...

  • Differential gene expression pattern in alveolar macrophages of patients with sarcoidosis and tuberculosis. Gaede, Karoline I.; Mamat, Uwe; Müller-Quernheim, Joachim // Journal of Molecular Medicine;Mar2004, Vol. 82 Issue 3, p206 

    Sarcoidosis is a multisystem granulomatous disorder of unknown origin characterized by the presence of epitheloid granulomata in the affected organs. Histological and clinical similarities between sarcoidosis and tuberculosis caused by M. tuberculosis suggest a shared underlying pathophysiology....

  • Carbon Nanotube-Induced Pulmonary Granulomatous Disease: Twist1 and Alveolar Macrophage M1 Activation. Barna, Barbara P.; Huizar, Isham; Malur, Anagha; McPeek, Matthew; Marshall, Irene; Jacob, Mark; Dobbs, Larry; Kavuru, Mani S.; Thomassen, Mary Jane // International Journal of Molecular Sciences;Dec2013, Vol. 14 Issue 12, p23858 

    Sarcoidosis, a chronic granulomatous disease of unknown cause, has been linked to several environmental risk factors, among which are some that may favor carbon nanotube formation. Using gene array data, we initially observed that bronchoalveolar lavage (BAL) cells from sarcoidosis patients...

  • Time Course of Gene Expression of Inflammatory Mediators in Rat Lung after Diesel Exhaust Particle Exposure. Rao, K. Murali Krishna; Ma, Jane Y. C.; Meighan, Terence; Barger, Mark W.; Pack, Donna; Vallyathan, Val // Environmental Health Perspectives;May2005, Vol. 113 Issue 5, p612 

    Diesel exhaust particles (DEPs) at three concentrations (5, 35, and 50 mg/kg body weight) were instilled into rats intratracheally. We studied gene expression at 1, 7, and 30 days postexposure in cells obtained by bronchoalveolar lavage (BAL) and in lung tissue. Using real-time reverse...

  • Telomerase reverse transcriptase mRNA expression and telomerase activity in hepatocellular carcinoma. Nagao, Kumi; Tomimatsu, Masahiko; Endo, Hitoshi; Hisatomi, Hisashi; Hikiji, Kazumasa // Journal of Gastroenterology;1999, Vol. 34 Issue 1, p83 

    Abstract: Human telomerase reverse transcriptase (hTERT) has been identified as the catalytic subunit of human telomerase. To clarify the clinical significance of hTERT mRNA in hepatocellular carcinoma (HCC), we investigated the relationship between telomerase activity and hTERT mRNA in human...


Read the Article


Sign out of this library

Other Topics