TITLE

T cell receptor genetics, autoimmunity and asthma

AUTHOR(S)
Frew, A J; Dasmahapatra, J
PUB. DATE
September 1995
SOURCE
Thorax;Sep1995, Vol. 50 Issue 9, p919
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
66026057

 

Related Articles

  • Allergic Disease and Autoimmune Effectors Pathways. Rottem, Menachem; Gershwin, M. Eric; Shoenfeld, Yehuda // Developmental Immunology;Sep2002, Vol. 9 Issue 3, p161 

    Allergy and autoimmunity result from dysregulation of the immune system. Until recently, it was generally accepted that the mechanisms that govern these disease processes are quite disparate; however, new discoveries suggest possible common pathogenetic effector pathways. This review illustrates...

  • Systemic Toll-Like Receptor Stimulation Suppresses Experimental Allergic Asthma and Autoimmune Diabetes in NOD Mice. Aumeunier, Aude; Grela, Fran├žoise; Ramadan, Abdulraouf; Van, Linh Pham; Bardel, Emilie; Alcala, Alejandro Gomez; Jeannin, Pascale; Akira, Shizuo; Bach, Jean-Fran├žois; Thieblemont, Nathalie // PLoS ONE;2010, Vol. 5 Issue 7, p1 

    Background: Infections may be associated with exacerbation of allergic and autoimmune diseases. Paradoxically, epidemiological and experimental data have shown that some microorganisms can also prevent these pathologies. This observation is at the origin of the hygiene hypothesis according to...

  • Narcolepsy and the T-cell receptor. Vyse, Timothy J. // Nature Genetics;Jun2009, Vol. 41 Issue 6, p640 

    The etiology of the sleep disorder narcolepsy has not been firmly established, although an autoimmune pathogenesis has been proposed and is supported by a strong genetic association with the HLA. A new genome-wide association study provides further support for the autoimmune basis of narcolepsy...

  • Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases. Stanford, Stephanie M.; Mustelin, Tomas M.; Bottini, Nunzio // Seminars in Immunopathology;Jun2010, Vol. 32 Issue 2, p127 

    A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine...

  • Toll-Like Receptors, Cytokines and the Immunotherapeutics of Asthma. Camateros, P.; Moisan, J.; Henault, J.; De Sanctis, J.; Skamene, E.; Radzioch, D. // Current Pharmaceutical Design;Jul2006, Vol. 12 Issue 19, p2365 

    Asthma is a complex disease caused by a poorly characterized set of genetic and environmental factors whose pathology is a result of immune dysregulation. Toll-like receptors are pathogen associated molecular pattern receptors expressed by many airway and pulmonary tissues as well as cells of...

  • Obesity and Asthma. Hauber, Hans-Peter; Wegmann, Michael // Recent Patents on Endocrine, Metabolic & Immune Drug Discovery;Nov2009, Vol. 3 Issue 3, p162 

    Prevalence of obesity and bronchial asthma is increasing in industrialized countries. Several studies have suggested a relationship between these disorders. Evidence comes from studies with animal models as well as epidemiologic observations. Moreover, pulmonary function parameters, genetic and...

  • CXCR3+CCR5+ T cells and autoimmune diseases: guilty as charged? Mackay, Charles R. // Journal of Clinical Investigation;Sep2014, Vol. 124 Issue 9, p3682 

    Prior to the 1990s, genetic analyses indicated that many autoimmune diseases are driven by T cell responses; however, the identity of the pathogenic T cell populations responsible for dysfunctional autoimmune responses remained unclear. Some 20 years ago, the discovery of numerous chemokines and...

  • B cell responses: Born to be (a bit) wild. Bordon, Yvonne // Nature Reviews Immunology;Dec2012, Vol. 12 Issue 12, p808 

    The article discusses the study which provides insight into the immune functions of Fc receptor B cells in the development of autoimmunity in humans and mice. The researchers have evaluated the functional relevance of genetic variations in mice with increased bystander activation of germinal...

  • Directed evolution for T-cell receptor stability. DeWitt, Natalie // Nature Biotechnology;Jul2000, Vol. 18 Issue 7, p703 

    Focuses on the improvement of robustness of T-cell receptors by directed evolution. Efforts to engineer soluble forms of T-cell receptors as antagonist of autoimmune disease.

  • Drug discovery: New Btk inhibitor holds promise. Hendriks, Rudi W. // Nature Chemical Biology;Jan2011, Vol. 7 Issue 1, p4 

    The article focuses on Bruton's tyrosine kinase (Btk) inhibitor or CGI1746. It states that Btk inhibition could be used for the treatment of autoimmune disorders and B cell lymphoma. It relates on its involvement in signal transduction of high receptors on basophils and mast cells. It adds that...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics