Ileal Intussusception Due to Intestinal Metastase from Primary Malignant Melanoma of the Lung

Testini, Mario; Di Venere, Beatrice; Trabucco, Senia; Piscitelli, Domenico; Albaugh, Gregory; Vemulapalli, Pratibha; Kann, Brian; Pello, Mark
April 2002
American Surgeon;Apr2002, Vol. 68 Issue 4, p377
Academic Journal
Primary malignant melanoma of the lung (PMML) is an uncommon tumor with very few cases reported in the literature that satisfy the required criteria to establish a primary bronchial origin. We report a case of a 44-year-old man with acute abdominal distress and a right pulmonary roentgenographic opacity. A cranial-thoracic-abdominal CT scan confirmed the presence of a pulmonary nodule with bilateral cerebral metastases and marked dilatation of intestinal loops. At laparotomy an ileal intussusception was noted and an ileal resection was done. The resected intestinal segment contained three endoluminal polypoidal formations. Histological and immunohistochemical analyses showed the presence of multiple sites of melanoma. These lesions as well as the brain lesions clearly appeared metastatic. The patient underwent further evaluation to identify a primary site of melanoma; bronchoscopy was performed with biopsy of the pulmonary nodule. Pathology revealed a neoplastic process of fusiform cells, with focal presence of melanic inter- and extracellular pigment. The immunohistochemical analysis confirmed the diagnosis of PMML. We discuss the criteria for diagnosis and histogenesis of PMML along with this unusual presentation.


Related Articles

  • Search for genes that suppress cancer metastasis. Fidler, Isaiah J.; Radinsky, Robert // JNCI: Journal of the National Cancer Institute;12/4/96, Vol. 88 Issue 23, p1700 

    Editorial. Addresses the importance of the study on the search for genes that suppress cancer metastasis. Pathogenesis of cancer metastasis; Recognition of the heterogeneity of neoplasms for metastatic properties; Mechanisms for genetic regulation of the metastatic processes.

  • Critical factors in the biology of human cancer metastasis. Fiddler, Isaiah J. // American Surgeon;Dec1995, Vol. 61 Issue 12, p1065 

    Examines the risk factors in human cancer metastasis. Mortality rate of cancer patients; Reasons for the failure to treat metastasis; Proposal for the improvement of cancer research; Principles of neoplasms.

  • Cutaneous metastases from primary internal malignancies: a retrospective study from a tertiary dermatological center in Northern Greece. Papadopoulos, I.; Ioannides, D.; Lefaki, I. // Hippokratia;2014, Vol. 18 Issue 2, p187 

    A letter to the editor is presented regarding the cutaneous metastases from primary internal malignancies in Northern Greece dermatological center.

  • ERRATUM.  // Archives of Pathology & Laboratory Medicine;Dec2011, Vol. 135 Issue 12, p1521 

    No abstract available.

  • New view of metastasis is spreading. Holzman, David // JNCI: Journal of the National Cancer Institute;10/2/96, Vol. 88 Issue 19, p1336 

    Reports on results of experiments conducted on metastasis using the technique called intravital videomicroscopy. Success of metastatic cells of entering circulation; Importance of the enzymes called metalloproteinases; Features of the model chorioallantoic membrane.

  • Erratum.  // JNCI: Journal of the National Cancer Institute;6/20/2007, Vol. 99 Issue 12, p977 

    A correction to the article "Requirement of KISS1 Secretion for Multiple Organ Metastatis Suppression and Maintenance of Tumor Dormancy" that was published in the no. 4, 2007 issue is presented.

  • Researchers Get New Insights into How Cancer Spreads.  // AARC Times;Aug2015, Vol. 39 Issue 8, p123 

    The article discusses research being done on microfluidic chip that can capture clusters of circulating tumor cells (CTCs), which references a study by Mehmet Toner et al. published in the May 18, 2015 issue of the journal "Nature Methods."

  • Which Squamous Cell Lesions. Barone Are Most Likely to Metastasize?, Pat // Dermatology Times;Mar1997, Vol. 18 Issue 3, p54 

    Presents significant statistics about squamous cell lesions that have the possibility to metastasize according to Dr. Ronald L. Moy. Indicators of metastasis potential; The use of Moh's micrographic surgery, standard surgical excision and radiation; Pathology and histology as an important...

  • Respiratory medicine.  // Clinical & Investigative Medicine;Aug97 Supplement, Vol. 20, pS96 

    Presents an abstract of the research manuscript `Weaning failure due to medullary metastasis,' by S. Corne et al.

  • Alveolar soft part sarcoma metastatic to small bowel mucosa causing polyposis and intussuseption. Sabel, Michael S.; Gibbs, John F.; Litwin, Allan; McGrath, Brian; Kraybill, William B.; Brooks, John J. // Sarcoma;Sep2001, Vol. 5 Issue 3, p133 

    A report of alveolar soft part sarcoma metastatic to the small bowel is presented. Hematogenous metastases to the small bowel from primary tumors outside the abdominal cavity are uncommon, and most remain asymptomatic and are not discovered until autopsy. However, small bowel metastases can lead...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics