TITLE

PHARMACOKINETICS OF ENROFLOXACIN IN DOGS WITH EXPERIMENTAL STAPHYLOCOCCAL INFECTION

AUTHOR(S)
DIMITROVA, D.; BORISSOV, I.; CHAPRAZOV, T. S.; GEORGIEVA, T.; YANEV, S.; PANDOVA, B.
PUB. DATE
September 2011
SOURCE
Bulgarian Journal of Veterinary Medicine;Sep2011, Vol. 14 Issue 3, p158
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The study investigated the effect of experimental Staphylococcus aureus bacterial infection on enrofloxacin pharmacokinetics in dogs. After infection, serum blood enrofloxacin concentrations and the values of AUC0→∞, Cmax, Tmax and t 1/2abs were higher. Other pharmacokinetic parameters (t1/2ß , MRT) exhibited an insignificant decrease. The infection resulted in lower serum concentrations of ciprofloxacin, the main metabolite of enrofloxacin. Statistically significantly lower biological half-life, lower AUC0→∞, Tmax, Cmax and MR were also observed.
ACCESSION #
65826790

 

Related Articles

  • Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus.  // BMC Microbiology;2011, Vol. 11 Issue 1, p241 

    The article focuses on a study conducted to analyze the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus. To characterize the efflux activity of 52 S. aureus isolates resistant to ciprofloxacin, several methodologies were used. In 12 out...

  • Correction: Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus. Costa, Sofia Santos; Falcão, Celeste; Viveiros, Miguel; Machado, Diana; Martina, Marta; Melo-Cristino, José; Amaral, Leonard; Couto, Isabel // BMC Microbiology;2013, Vol. 13 Issue 1, p1 

    A correction to the article "Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus" that was published in the previous issue is presented.

  • Shift in dominant hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) clones over time. Knight, Gwenan M.; Budd, Emma L.; Whitney, Laura; Thornley, Alastair; Al-Ghusein, Hasan; Planche, Timothy; Lindsay, Jodi A. // Journal of Antimicrobial Chemotherapy (JAC);Oct2012, Vol. 67 Issue 10, p2514 

    Objectives The majority of HA-MRSA infections are caused by endogenous infection and by only a small number of clones. The reasons for the success of some clones over others are unknown. Methods We investigated the evolution of an MRSA population from a large, acute-care teaching hospital in...

  • Functional relationship between bacterial cell density and the efficacy of antibiotics. Klas I. Udekwu; Nicholas Parrish; Peter Ankomah; Fernando Baquero; Bruce R. Levin // Journal of Antimicrobial Chemotherapy (JAC);Apr2009, Vol. 63 Issue 4, p745 

    Objectives To determine the functional relationship between the density of bacteria and the pharmacodynamics of antibiotics, and the potential consequences of this inoculum effect on the microbiological course of antibiotic treatment of Staphylococcus aureus infections. Methods In vitro...

  • Meticillin-resistant staphylococci in companion animals. Heller, Jane // Veterinary Record: Journal of the British Veterinary Association;7/16/2011, Vol. 169 Issue 3, p68 

    The author discusses several studies on meticillin-resistant Staphylococcus aureus (MRSA) in dogs and cats. Humans were responsible for MRSA in dogs and cats, according to the results of molecular typing. Staphylococcus pseudintermedius is identified as the most common staphylococcal commensal...

  • Kill kinetics of advanced-generation fluoroquinolones compared in study. Guttman, Cheryl // Ophthalmology Times;9/15/2009, Vol. 34 Issue 18, p28 

    The article reports on the findings of an in vitro kill kinetics study in 18 human ophthalmic Staphylococcus isolates, comparing the bacterial efficacy of fluoroquinolones. The study found that the commercial formulation of gatifloxacin has demonstrated superior activity which consistently...

  • Preop antibiotic offers infection prophylaxis. O'Callaghan, Richard J.; Eiferman, Richard; Lane, Stephen S. // Ophthalmology Times;11/01/2000, Vol. 25 Issue 21, p1 

    Reports on the true prophylaxis produced by ciproflaxin antibiotic against Staphylococcus aureus infection. Views on antibiotic effectiveness; Effectiveness of the antibiotic applied on occular area compared to oflaxin antibiotic; Clinical relevance of both antibiotic.

  • Ciprofloxacin-loaded Chitosan nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections. De Giglio, Elvira; Trapani, Adriana; Cafagna, Damiana; Ferretti, Concetta; Iatta, Roberta; Cometa, Stefania; Ceci, Edmondo; Romanelli, Antonella; Mattioli-Belmonte, Monica // Nano Biomedicine & Engineering;2012, Vol. 4 Issue 4, p163 

    Orthopaedic infections represent one of the major causes of implant failure. Systemic treatment is limited due to dosing, side-effects, patient compliance, treatment length and resistant bacteria. The choice of antibiotic incorporation method has been the subject of many investigations and,...

  • Antimicrobial activity induced by a Sulfathiazole derivative on Staphylococcus aureus, and Vibrio cholerae. L. Figueroa-Valverde; F. Díaz-Cedillo; A . Camacho-Luis; E. García-Cervera; E. Pool-Gómez; M. López-Ramos; B. Sarabia-Alcocer; I. May-Gil; A. Sarao-Álvarez; G. Ancona-Leon // International Journal of PharmTech Research;Jul-Sep2013, Vol. 5 Issue 3, p1247 

    In this work the antibacterial activity of asulfathiazole derivative was evaluated against both Staphylococcus aureus and Vibrio cholerae using cefotaxime, gentamicin, ciprofloxacin and sulfathiazole as controls. The evaluation of antimicrobial effect of the different compounds on the bacterial...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics