The systemic inflammatory response syndrome following cardiac surgery: different expression of proinflammatory cytokines and procalcitonin in patients with and without multiorgan dysfunctions

Sablotzki, Armin; Friedrich, Ivar; Mühling, Jörg; Dehne, Marius G; Spillner, Jan; Silber, Rolf E; Czeslik, Elke
March 2002
Perfusion;Mar2002, Vol. 17 Issue 2, p103
Academic Journal
Cardiopulmonary bypass is associated with an injury that may cause pathophysiological changes in the form of systemic inflammatory response syndrome (SIRS) or multiple organ dysfunction syndrome (MODS). In the present study, we investigated the inflammatory response of patients with multiple organ dysfunctions following open-heart surgery. Plasma levels of cytokines (IL-1β, IL-6, IL-8, IL-18) and procalcitonin (PCT) were measured on the first four postoperative days in 12 adult male patients with SIRS and two or more organ dysfunctions after myocardial revascularization (MODS group), and 15 patients without organ dysfunctions (SIRS group). All cytokines (except IL-1β) and PCT were significantly elevated in MODS patients, with peak values at the first two post-operative days. The results of our study show a different expression of members of the IL-1 family following extracorporeal circulation. For the first time, we can document that IL-18 is involved in the inflammatory response and the initiation of the MODS following cardiopulmonary bypass. In addition to APACHE-II score, PCT, IL-8, and IL-18 may be used as parameters for the prognosis of patients with organ dysfunctions after cardiac surgery. Furthermore, it must be noted that the duration of the surgical procedure is one of the most important factors for the initiation of the inflammatory response.


Related Articles

  • VASA PRIVATA AND VASA PUBLICA. Blond, K. // Angiology;May1965, Vol. 16 Issue 5, p246 

    Provides the medical information about vasa afferentia and vas publicum afferens of the liver. Causes of the changes of the venous patterns; Terminologies for the bypass of the lung and the liver; Inclusions of the pathologic conditions.

  • Book reviews. Anderson, Jon; Toomasian, John M. // Perfusion;Mar2001, Vol. 16 Issue 2, p175 

    Reviews two books on cardiopulmonary management. 'Cardiopulmonary Bypass: Principles and Practice,' 2nd edition, edited by G.P. Gravlee, R.F. Davis, M. Kurusz, J.P. Utley; 'ECMO: Extracorporeal Cardiopulmonary Support in Critical Care,' 2nd edition, edited by J.B. Zwischenberger, R.H....

  • Reporting of perfusion-related incidents: pitfalls and limitations. Svenmarker, Staffan; Appelblad, Micael // Perfusion;Sep2005, Vol. 20 Issue 5, p243 

    Presents a study on the safety and risk-containment associated with cardiopulmonary bypass procedures (CPB). Development of the extracorporeal technology; Concern of air embolism; Inclusion of the historical glimpses of safety assessment in cardiopulmonary bypass.

  • Cardiopulmonary Bypass Surgery in Children: Minimizing the Incidence of Postoperative Junctional Ectopic Tachycardia after Surgical Technique Modification. Azhar, Ahmad Saeed // American Journal of Biomedical Sciences;Jan2012, Vol. 4 Issue 1, p79 

    Background: Mechanical injury to tissues in and surrounding the Atrioventricular node is considered a major factor in the aetiology of postoperative Junctional Ectopic Tachycardia (JET). Objectives: The study aims to evaluate the effect of retractor modification used during cardiopulmonary...

  • States of low pulmonary blood flow can be detected non-invasively at the bedside measuring alveolar dead space. Tusman, Gerardo; Suarez-Sipmann, Fernando; Paez, Gabriel; Alvarez, Jorge; Bohm, Stephan // Journal of Clinical Monitoring & Computing;Jun2012, Vol. 26 Issue 3, p183 

    We tested whether the ratio of alveolar dead space to alveolar tidal volume (VD/VT) can detect states of low pulmonary blood flow (PBF) in a non-invasive way. Fifteen patients undergoing cardiovascular surgeries with cardiopulmonary bypass (CPB) were studied. CPB is a technique that excludes the...

  • CORR Insights: Complications of Cemented Long-stem Hip Arthroplasties in Metastatic Bone Disease Revisited. Terek, Richard // Clinical Orthopaedics & Related Research;Oct2013, Vol. 471 Issue 10, p3308 

    The article comments on the article ''Complications of Cemented Long-stem Hip Arthroplasties in Metastatic Bone Disease Revisited''. It states that the authors of the article reported the transient cardiopulmonary derangements and long-stem femoral implants as a feasible surgical option. It also...

  • Intrapericardial immature teratoma in a newborn: a case report. Milovanovic, Vladimir; Lukac, Marija; Krstic, Zoran // Cardiology in the Young;Feb2014, Vol. 24 Issue 1, p164 

    Intrapericardial teratomas are extremely rare and most often benign tumours. In this paper, we have described a case of intrapericardial teratoma diagnosed prenatally and successfully operated. The presented case is noteworthy as an example of potentially catastrophic cardiorespiratory distress...

  • ANTI-INFLAMMATORY MONOCYTES ARE INDUCED FOLLOWING CARDIOPULMONARY BYPASS SURGERY. Philippidis, P.; Taylor, K. M.; Haskard, D. O.; Landis, R. C. // Heart;May2004 Supplement 2, Vol. 90, pA29 

    This article focuses on a study that shows anti-inflammatory monocytes are induced following cardiopulmonary bypass surgery. Circulating monocyte activation at 2-4 hours following the onset of cardiopulmonary bypass surgery is commonly thought to potentiate systemic inflammatory responses and...

  • Modified Blalock Taussig shunt: a not-so-simple palliative procedure. Dirks, Verena; Prêtre, René; Knirsch, Walter; Valsangiacomo Buechel, Emanuela R.; Seifert, Burkhardt; Schweiger, Martin; Hübler, Michael; Dave, Hitendu // European Journal of Cardio-Thoracic Surgery;Dec2013, Vol. 44 Issue 6, p1096 

    OBJECTIVES Thirty-two consecutive isolated modified Blalock Taussig (BT) shunts performed in infancy since 2004 were reviewed and analysed to identify the risk factors for shunt intervention and mortality. METHODS Sternotomy was the only approach used. Median age and weight were 10.5 (range...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics