TITLE

Levels of inflammatory markers in the blood processed by autotransfusion devices during cardiac surgery associated with cardiopulmonary bypass circuit

AUTHOR(S)
Amand, T; Pincemail, J; Blaffart, F; Larbuisson, R; Limet, R; Defraigne, JO
PUB. DATE
March 2002
SOURCE
Perfusion;Mar2002, Vol. 17 Issue 2, p117
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Intraoperative blood salvage devices allowing a reinfusion of red blood cells (RBCs) after processing of shed blood and stagnantblood in the mediastinal cavity are more and more used to reduce homologous blood requirements in cardiac surgery with cardiopulmonary bypass (CPB). As the proinflammatory activity of the shed blood also contributes to morbidity during CPB, we conducted a prospective study in order to examine the quality of autologous blood before and after processing with five different devices [BRAT2, Sequestra, Compact Advanced, Cell Saver 5 (CS5), Continuous Autologous Transfusion System (CATS)]. All systems resulted in an excellent haemoconcentration, ranging from 53.7% (Compact) to 68.9% (CATS). The concentrations and elimination rates of several inflammatory markers [IL-1β, IL-2, IL-8, TNFα, myeloperoxidase (MPO), elastase] were examined. Except for the Sequestra, an important increase in concentration of IL-1β (between 30% and 220%) has been observed after processing with each device. In contrast, the attenuation rate of IL-6 and TNFα (95%) was optimal for all investigated blood salvages systems. Regarding IL-8, only the CATS and CS5 systems were able to attenuate this biological parameter with an excellent efficacy. The rate of attenuation in MPO and elastase, as markers of leukocyte activation, was higher than 80% for all devices. In conclusion, the different RBC washing systems tested in this study resulted in a significant attenuation of the inflammatory response. Increased levels of IL-1β after processing remained, however, unclear. According to the type of protocol, based on inlet haematocrit, fill and wash speeds, and wash volumes, small variations in reducing the inflammatory response have been observed from one device to another.
ACCESSION #
6567726

 

Related Articles

  • XAD-4 resin hemoperfusion for digitoxic patients with renal failure. Hoy, Wendy E.; Gibson, Thomas P.; Rivero, Alejandro J.; Jain, Vijay K.; Talley, Thomas T.; Bayer, Richard M.; Montondo, Daniel F.; Freeman, Richard B. // Kidney International;Jan1983, Vol. 23 Issue 1, p79 

    The article aims to discuss the clinical course and characteristics of XAD-4 hemoperfusion in three patients with renal failure and refractory manifestations of digoxin toxicity. The researchers quantified the plasma digoxin by radioimmunoassay and measured the red blood cell (RBC)-surface...

  • Hyperkalemia of the blood-primed ECLS circuit does not result in post-initiation hyperkalemia in infants <10 kg. Fleming, Geoffrey M; Remenapp, Robert T; Bartlett, Robert H; Annich, Gail M // Perfusion;May2006, Vol. 21 Issue 3, p173 

    Objective: To assess the risk of hyperkalemia with blood-primed extracorporeal life support (ECLS) circuits in infants <10 kg. Design: Retrospective cohort study of all neonatal and pediatric patients <10 kg placed on ECLS from May 1998 to April 2001. Measurements and main results: Data...

  • Postoperative Morbidity Following Red Cell Deformability Changes During Cardiopulmonary Bypass Using Bubble and Membrane Oxygenators. Belboul, Ali; Khaja, Najib Al; Bergman, Per; Roberts, Donald; William-Olsson, Göran // Vascular Surgery;Jul/Aug1989, Vol. 23 Issue 4, p258 

    The preoperative blood cell trauma and postoperative morbidity were compared in a prospective randomized study in two groups of patients undergoing cardiac surgery with extracorporeal circulation (ECC). One group was oxygenated during ECC with a membrane oxygenator (MO) and the other with a...

  • Changes in potassium concentration and haematocrit associated with cardiopulmonary bypass in paediatric cardiac surgery. Vohra, Hunaid A.; Adluri, Krishna; Willets, Robert; Horsburgh, Angela; Barron, David J.; Brawn, William J. // Perfusion;Mar2007, Vol. 22 Issue 2, p87 

    Introduction: A blood prime is frequently required for paediatric bypass surgery to maintain adequate haematocrit (Hct). However, stored blood can have high extracellular potassium levels and this study aims to investigate the effect of stored blood on the potassium concentration, both in the...

  • The minimized extracorporeal circulation system causes less inflammation and organ damage. Kofidis, T.; Baraki, H.; Singh, H.; Kamiya, H.; Winterhalter, M.; Didilis, V.; Emmert, M.; Woitek, F.; Haverich, A.; Klima, U. // Perfusion;May2008, Vol. 23 Issue 3, p147 

    The minimized extracorporeal circulation system (MECC) is being used to reduce priming volume and blood/polymer contact during cardiac procedures. In this study, we evaluated the efficacy and potential advantages of the system in coronary artery bypass graft (CABG) patients. We included two...

  • heart-lung machine. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p370 

    An encyclopedia entry for "heart-lung machine" is presented. It refers to a machine that temporarily takes over the function of the heart and lungs in order to facilitate operations. The machine is used in open heart surgery, heart transplant and heart-lung transplant. Complications of the use...

  • Designer arteries. Campbell, Julie; Campbell, Gordon // Australasian Science;Oct2000, Vol. 21 Issue 9, p36 

    Discusses the development of artificial arteries which can be used to replace or bypass diseased arteries. Limitations of synthetic vascular implants; Benefits of artificial arteries.

  • Trouble with Your Ticker? Bag It. Kirschner, Suzanne Kantra; Moyer, Michael // Popular Science;Feb2002, Vol. 260 Issue 2, p11 

    Introduces a mesh-like jacket that protects the heart's muscles against the stretching resulted from stress that leads to heart failure.

  • Study buoys Vascomedical.  // Long Island Business News (7/1993 to 5/2009);9/13/2002, Vol. 49 Issue 39, p9A 

    Reports on the research about the effect of the external counterpulsation system of Vasomedical Inc. on coronary blood flow in Westbury, New York. Increase in the blood flow; Efficacy of the system.

Share

Read the Article

Courtesy of

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics