New melanoma drug requires gene mutation test

Thompson, Cheryl A.
October 2011
American Journal of Health-System Pharmacy;10/1/2011, Vol. 68 Issue 19, p1764
Academic Journal
The article reports the FDA approval of vemurafenib, marketed as Zelboraf by Roche Group's Genentech, for use against melanoma having a V600E genetic mutation in the gene that encodes the protein kinase BRAF. The article mentions that a study shows that vemurafenib helps improve overall survival in patients, with a risk of cutaneous squamous cell carcinoma in 26 percent of treated patients. It is mentioned that the drug is available only through specialty pharmacies.


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