Stability of levothyroxine injection in glass, polyvinyl chloride, and polyolefin containers

Frenette, Anne Julie; MacLean, Robert D.; Williamson, David; Marsolais, Pierre; Donnelly, Ronald F.
September 2011
American Journal of Health-System Pharmacy;9/15/2011, Vol. 68 Issue 18, p1723
Academic Journal
Purpose. The 24-hour stability of a levothyroxine solution admixed and stored in three common infusion containers and infused through polyvinyl chloride (PVC) tubing was evaluated. Methods. Levothyroxine sodium 1-mg/mL injection prepared in glass bottles and PVC and polyolefin bags were assayed using high-performance liquid chromatography at 0, 1, 3, 6, 12, and 24 hours; samples drawn directly from the containers, as well as from the distal end of attached PVC tubing, were assayed. The area under the time-versus-concentration curve (AUC) for predicted and delivered doses was calculated; analysis of variance was used for comparison of the percentages of predicted and actual AUC values. Results. The levothyroxine concentration was stable in glass bottles and polyolefin bags through 24 hours (mean ± S.D. percentage of initial concentration remaining, 103.5% ± 2.5% and 100.0% ± 2.9%, respectively). In the PVC infusion bags, the amount of drug decreased to 90% of the initial concentration within 1 hour and then rose and remained within acceptability limits. The levothyroxine concentration of the samples infused through PVC line from glass and polyolefin containers decreased after 1 hour by about 13%; the loss of the drug from the samples infused from PVC bags was higher (18%), presumably due to additive adsorptive effects. In all samples tested, the drug concentration rebounded and remained above 90% to the end of the study. Conclusion. Levothyroxine sodium 1-μg/ mL solution was stable for 24 hours in glass bottles and polyolefin bags but when stored in PVC bags, the concentration decreased by 10% after 1 hour.


Related Articles

  • Infusion pump update. Skokal, Wendy A.; Moore, Amy Slugg // RN;Oct97, Vol. 60 Issue 10, p35 

    Presents an overview of infusion pumps on the market for 1997. Information on infusion regulation; Features of these devices; How these devices simplify intravenous (IV) therapy; How to determine which device is best. INSET: What's new in infusion pumps..

  • Pressure infusion cuff.  // Materials Management in Health Care;Feb97, Vol. 6 Issue 2, p52 

    Features the pressure infusion cuffs from Kawasumi Laboratories America. Design; Advantages.

  • WHO Addresses Safety For Patients Worldwide.  // RN;Dec2005, Vol. 68 Issue 12, p18 

    This article focuses on the efforts of the World Health Organization (WHO) to address healthcare errors harming patients around the world. The WHO Collaborating Centre would create international information campaigns to highlight best safety practices. The WHO has also created hand hygiene...

  • Antioxidant and Antiradical Activities of Manihot esculenta Crantz (Euphorbiaceae) Leaves and Other Selected Tropical Green Vegetables Investigated on Lipoperoxidation and Phorbol-12-myristate-13-acetate (PMA) Activated Monocytes. Tsumbu, Cesar N.; Deby-Dupont, Ginette; Tits, Monique; Angenot, Luc; Franck, Thierry; Serteyn, Didier; Mouithys-Mickalad, Ange // Nutrients;Sep2011, Vol. 3 Issue 9, p818 

    Abelmoschus esculentus (Malvaceae), Hibiscus acetosella (Malvaceae), Manihot esculenta Crantz (Euphorbiaceae) and Pteridium aquilinum (Dennstaedtiaceae) leaves are currently consumed as vegetables by migrants from sub-Saharan Africa living in Western Europe and by the people in the origin...

  • Influence of Implant Geometry on Primary Insertion Stability and Simulated Peri-implant Bone Loss: An In Vitro Study Using Resonance Frequency Analysis and Damping Capacity Assessment. Lachmann, Stefan; Laval, Johannes Yves; Axmann, Detlef; Weber, Heiner // International Journal of Oral & Maxillofacial Implants;2011, Vol. 26 Issue 2, p347 

    Purpose: To investigate the influence of implant geometry on primary stability and on peri-implant bone loss in an in vitro model using the Periotest and Osstell devices. Materials and Methods: Screw-type implants of various diameters and lengths were inserted into bovine bone blocks of...

  • In vivo biofilm formation on different dental ceramics. Bremer, Felicia; Grade, Sebastian; Kohorst, Philipp; Stiesch, Meike // Quintessence International;2011, Vol. 42 Issue 7, p565 

    Objectives: To investigate the formation of oral biofilm on various dental ceramics in vivo. Method and Materials: Five different ceramic materials were included: a veneering glass- ceramic, a lithium disilicate glass-ceramic, a yttrium-stabilized zirconia (Y-TZP), a hot isostatically pressed...

  • Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R. Parker and its phytochemical analysis. Afsar, Tayyaba; Khan, Muhammad Rashid; Razak, Suhail; Ullah, Shafi; Mirza, Bushra // BMC Complementary & Alternative Medicine;2015, Vol. 15 Issue 1, p1 

    Background: Inflammation and pain underlies several pathological conditions. Synthetic drugs used for the management of these conditions carry severe toxic effects. Globally efforts are ongoing to introduce novel medicinal plants to develop effective, economic and innocuous drugs. The current...

  • Antipyretic and antinociceptive potential of extract/fractions of Potentilla and its isolated compound, acacetin. Rauf, Abdur; Khan, Rehan; Khan, Haroon; Ullah, Barkat; Pervez, Samreen // BMC Complementary & Alternative Medicine;2014, Vol. 14 Issue 1, p1 

    Background Fever and pain management is a very challenging job for the clinician as the available synthetic agents are causing serious side effects. The present research article deals with the antipyretic and antinociceptive activity of extract/fractions of Potentilla evestita and acacetin...

  • PAIN Portable relive for terminal patients. Hannon, Dawn; Wrobel, Sharon; Dennis, Ellen // RN;Jan85, Vol. 48 Issue 1, p37 

    Presents a procedure that makes use of ambulatory infusion pumps to administer intravenous morphine sulfate for patients at home. Effectiveness of the procedure for controlling pain; Details on the use of ambulatory infusion pumps with a terminal renal cancer patient.

  • infusion pump.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1194 

    A reference entry for "infusion pump" which refers to a pump employed to provide fluids into an artery, vein, or enteral tube is presented.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics