Phase transformation of calcium phosphates in the presence of glutamic acid

Tsai, Tim W. T.; Chen, Wei-Ya; Tseng, Yao-Hung; Chan, Jerry C. C.
July 2011
Canadian Journal of Chemistry;Jul2011, Vol. 89 Issue 7, p885
Academic Journal
This work describes a phase-transformation pathway of calcium phosphate in the presence of glutamic acid. The route follows the order starting from amorphous calcium phosphate and brushite, then octacalcium phosphate (OCP), and finally hydroxyapatite (HAp). The preferred growth direction of the intermediate OCP and the final HAp phases lies along the c axis. On the basis of our scanning electron microscopy, X-ray powder diffraction, and 31P solid-state NMR data, we suggest that the transformation is via the dissolution-reprecipitation process, which is facilitated in the presence of glutamic acid. The effect on the transformation kinetics is rationalized by the disruption of the water layer bound on the crystal surface.


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