TITLE

Inflammation in Chronic SCI

AUTHOR(S)
GRILL, RAYMONDQ
PUB. DATE
October 2011
SOURCE
PN;Oct2011, Vol. 65 Issue 10, p48
SOURCE TYPE
Trade Publication
DOC. TYPE
Article
ABSTRACT
The article presents a study on the treatment of the inflammation in chronic spinal cord injury (SCI). It utilizes chronically injured rat models treated with Licofelone through oral medication for 30 days. Post-mortem analysis was performed to assess the metabolites within the injured spinal cord of the models. Results show the potential development of Licofelone as novel intervention for chronically injured patients.
ACCESSION #
65525939

 

Related Articles

  • Effect of 4-aminopyridine and single-dose methylprednisolone on functional recovery after a chronic spinal cord injury. Haghighi, Siavash S; Clapper, Adam; Johnson, Gayle C; Stevens, Amy; Prapaisilp, Arisa // Spinal Cord;Jan1998, Vol. 36 Issue 1, p6 

    The demyelination process is an important factor contributing to long term sensory and motor impairments after spinal cord injury (SCI). Exposure of axonal K+ channels after demyelination may contribute to blockage of action potentials across the injury site. A K+ channel blocker,...

  • Histopathological Changes in Knee Joint Components after Spinal Cord Injury in Rats. Kitade, Ippei; Hoso, Masahiro; Matsuzaki, Taro; Inaoka, Pleiades Tiharu; Kamijyo, Akio; Araki, Yoshitaka; Takahashi, Ikufumi // Journal of Physical Therapy Science;2012, Vol. 24 Issue 1, p31 

    The article discusses a study to establish spinal cord injury (SCI) model rats to study histopathological changes in their knee joint components. Dilatation and congestion of the microvasculature and lymphoid infiltration were observed in the synovial membrane in the SCI group. The study...

  • Quercetin attenuates inflammatory processes after spinal cord injury in an animal model. Schültke, E; Griebel, R W; Juurlink, B H J // Spinal Cord;Dec2010, Vol. 48 Issue 12, p857 

    Objectives:We have shown earlier that administration of the flavonoid quercetin significantly contributed to recovery of motor function after spinal cord compression injury in the adult rat. Using the same animal model, we have now designed a set of experiments to test the hypothesis that...

  • Cellular Imaging of Inflammation after Experimental Spinal Cord Injury. Dunn, Elizabeth A.; Weaver, Lynne C.; Dekaban, Gregory A.; Foster, Paula J. // Molecular Imaging;Jan2005, Vol. 4 Issue 1, p53 

    The ability to visualize the cellular inflammatory responses after experimental spinal cord injury (SCI) was investigated using a clinical 1.5-T magnetic resonance imaging scanner, a custom-built, high-strength gradient coil insert, a 3-D fast imaging employing steady-state acquisition (FIESTA)...

  • Glucocorticoid-Induced Leucine Zipper (GILZ) Over-Expression in T Lymphocytes Inhibits Inflammation and Tissue Damage in Spinal Cord Injury. Esposito, Emanuela; Bruscoli, Stefano; Mazzon, Emanuela; Paterniti, Irene; Coppo, Maddalena; Velardi, Enrico; Cuzzocrea, Salvatore; Riccardi, Carlo // Neurotherapeutics;Jan2012, Vol. 9 Issue 1, p210 

    Spinal cord injury (SCI) is a traumatic event that causes a secondary and extended inflammation characterized by infiltration of immune cells, including T lymphocytes, release of pro-inflammatory mediators in the lesion site, and tissue degeneration. Current therapeutic approaches for SCI are...

  • Inflammation & apoptosis in spinal cord injury. Ning Zhang; Ying Yin; Sheng-Jie Xu; Yong-Ping Wu; Wei-Shan Chen // Indian Journal of Medical Research;Mar2012, Vol. 135 Issue 3, p287 

    Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical injury followed by an inflammatory process and apoptosis. Secondary insult is characterized by further destruction of neuronal and glial cells, and leads to expansion of the damage, so that the paralysis can...

  • Neuroprotective effect of ginseng against spinal cord injury induced oxidative stress and inflammatory responses. Wei Wang; Hao Shen; Jing-Jing Xie; Jian Ling; Hua Lu // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 3, p3514 

    The pathophysiological effects of spinal cord injury (SCI) occur as a result of oxidative stress and inflammatory mechanisms. In the present study we analyzed the protective role of ginseng on spinal injury in wistar rats. To evaluate the redox status, we investigated various parameters...

  • Low-Grade Inflammation and Spinal Cord Injury: Exercise as Therapy? da Silva Alves, Eduardo; de Aquino Lemos, Valdir; Ruiz da Silva, Francieli; Santos Lira, Fabio; Vagner Thomathieli dos Santos, Ronaldo; Pereira Rosa, João Paulo; Caperuto, Erico; Tufik, Sergio; Tulio de Mello, Marco // Mediators of Inflammation;2013, Vol. 2013, p1 

    An increase in the prevalence of obesity in people with spinal cord injury can contribute to low-grade chronic inflammation and increase the risk of infection in this population. A decrease in sympathetic activity contributes to immunosuppression due to the lower activation of immune cells in...

  • Enhanced neuropathic pain following intraspinaly injection of Schwann cells in contusion model of spinal cord injury. Pourheydar B.; Joghataei M. T.; Najafzadeh N. // Journal of Urmia Nursing & Midwifery Faculty;May/Jun2012, Vol. 10 Issue 2, p1 

    Background & Aims: Spinal cord injury (SCI) leads to sensorimotor deficits and neuropathic pain (NP). Cell therapy is a common method for treatment of SCI. The mechanism which has been explained for development of NP including: transplantation of stem cell leads to differentiation of these cells...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics