TITLE

Proteomic Analyses of Proteins Differentially Expressed in Recurrent and Primary Pterygia

AUTHOR(S)
Kanamoto, Takashi; Souchelnytskyi, Nazariy; Toda, Ryotaro; Rimayanti, Ulfah; Kiuch, Yoshiaki
PUB. DATE
March 2011
SOURCE
Journal of Proteomics & Bioinformatics;2011, Vol. 4 Issue 3, p58
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We describe a proteomic approach to identify proteins which may be involved in the recurrence of pterygia. Tissues from a recurrent pterygium and from a primary pterygium were surgically resected and were analyzed by proteomics to identify proteins that were significantly up- or down-regulated. The proteins showing significant differences in the two tissues were identified by mass spectrometry. Eleven proteins were differentially expressed; seven proteins were up-regulated and four proteins were down-regulated in the recurrent pterygium. The identified proteins are known to regulate cell cycle, cell organization, extracellular matrix, cholesterol metabolism, and cell signaling. Up- and down-regulation of proteins for cellular signaling are most likely involved in the recurrence of pterygia.
ACCESSION #
65471142

 

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