Ticagrelor Tablets (Brilinta)

Elliott, William T.; Chan, James
August 2011
Internal Medicine Alert;8/29/2011, Vol. 33 Issue 16, p126
The article offers information on Ticagrelor, an adenosine diphosphate receptor P2Y12 inhibitor which has been approved by the U.S. Food and Drug Administration (FDA) to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome (ACS).


Related Articles

  • Sulfonylurea Receptor.  // Encyclopedic Reference of Molecular Pharmacology;2004, p891 

    An encyclopedia entry for sulfonylurea receptor is presented. This refers to a regulatory subunit of the adenosine triphosphate-dependent potassium channel. It contains two nucleotide-binding folds and multiple transmembrane domains. Loss of sulfonylurea receptor may result to spontaneous...

  • Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes. Wallentin, Lars; Becker, Richard C.; Budaj, Andrzej; Cannon, Christopher P.; Emanuelsson, H�kan; Held, Claes; Horrow, Jay; Husted, Steen; James, Stefan; Katus, Hugo; Mahaffey, Kenneth W.; Scirica, Benjamin M.; Skene, Allan; Steg, Philippe Gabriel; Storey, Robert F.; Harrington, Robert A. // New England Journal of Medicine;9/10/2009, Vol. 361 Issue 11, p1045 

    Background: Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel. Methods: In this multicenter, double-blind, randomized trial, we compared ticagrelor (180-mg...

  • Reversal of Thienopyridine-Induced Platelet Dysfunction Following Desmopressin Administration. Levine, Michael; Swenson, Steve; McCormick, Taylor; Henderson, Sean; Thomas, Stephen; Markland, Francis // Journal of Medical Toxicology;Jun2013, Vol. 9 Issue 2, p139 

    Adenosine diphosphate (ADP)-receptor antagonists are widely used for thrombus prevention, although reversing their platelet dysfunction is difficult. This study evaluated the ability of desmopressin to reverse clopidogrel-induced platelet dysfunction. Sprague-Dawley rats received either...

  • Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP): Novel Regulators of Ca 2+-Signaling and Cell Function. Guse, Andreas H. // Current Molecular Medicine;May2002, Vol. 2 Issue 3, p273 

    Ca 2+ ions are involved in the regulation of many diverse functions in animal and plant cells, e.g. muscle contraction, secretion of neurotransmitters, hormones and enzymes, fertilization of oocytes, and lymphocyte activation and proliferation. The intracellular Ca 2+ concentration can be...

  • High Throughput Fluorescence-Based Assays for Cyclic ADP-Ribose, NAADP, and Their Metabolic Enzymes. Graeff, Richard M.; Hon Cheung Lee // Combinatorial Chemistry & High Throughput Screening;Jun2003, Vol. 6 Issue 4, p367 

    Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two novel Ca2+ messengers derived respectively from NAD and NADP. Since their discovery in sea urchin eggs, both have now been shown to serve messenger functions in a wide range of cells from plant to human....

  • Platelet ADP Receptors and their Antagonists. Benoit, Patricia; Dogne, Jean-Michel // Mini Reviews in Medicinal Chemistry;Mar2003, Vol. 3 Issue 2, p145 

    ADP plays a crucial role in haemostasis and thrombosis and its receptors are potential target for antithrombotic drugs.The knowledge of the ADP-receptors has been amplified by recent discoveries. This review highlights the ADP-receptors models and their antagonists described in the recent...

  • Membrane Traffic: Sort and transport. Smallridge, Rachel // Nature Reviews Molecular Cell Biology;Feb2003, Vol. 4 Issue 2, p89 

    Discusses research being done on the interactions that deliver Golgi-localized, γ-ear-containing, adenosine diphosphate-ribosylation factor-binding (GGA) proteins to endosomes. Reference to a study published in 'The EMBO Journal'; Interaction of the human GGA with Rabaptin-5 protein; Change...

  • The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family. Gabelli, Sandra B.; Bianchet, Mario A.; Bessman, Maurice J.; Amzel, L. Mario // Nature Structural Biology;May2001, Vol. 8 Issue 5, p467 

    Regulation of cellular levels of ADP-ribose is important in preventing nonenzymatic ADP-ribosylation of proteins. The Escherichia coli ADP-ribose pyrophosphatase, a Nudix enzyme, catalyzes the hydrolysis of ADP-ribose to ribose-5-P and AMP, compounds that can be recycled as part of nucleotide...

  • The Colinearity of the Sh2/A1 Orthologous Region in Rice, Sorghum and Maize is Interrupted and Accompanied by Genome Expansion in the Triticeae. Wanlong Li; Gill, Bikram S. // Genetics;Mar2002, Vol. 160 Issue 3, p1153 

    Examines the colinearity ofSh2/A1 orthologous region in rice, sorghum and maize for genome expansion in the triticeae. Description on subcloning and sequence analysis; Isolation of adenosine diphosphate pyrophosphorylase from wheat; Demonstration on tandem duplication of functional A1 genes in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics