Universal Flu Vaccine Study Yields Success in Mice

July 2011
International Journal of Virology;2011, Vol. 7 Issue 2, p87
Academic Journal
No abstract available.


Related Articles

  • Cross-protection of Lactococcus lactis-displayed HA2 subunit against homologous and heterologous influenza A viruses in mice. Lei, Han; Peng, Xiaojue; Zhao, Daxian; Jiao, Huifeng; Ouyang, Jiexiu // Archives of Virology;Dec2015, Vol. 160 Issue 12, p3011 

    Current influenza vaccines provide strain-specific protection against homologous subtypes and need to be updated annually. Therefore, it is essential to develop a universal vaccine that would induce broadly cross-protective immunity against homologous and heterologous influenza A viruses. The...

  • Immunology: Holistic medicine.  // Nature;9/11/2008, Vol. 455 Issue 7210, p140 

    The article highlights a research, conducted by a team led by Anke Huckriede at the University of Groningen in the Netherlands, that examined the role of viral single-stranded ribonucleic acid (RNA) molecules in enhancing the efficiency of H5N1 influenza vaccine. The team showed that for this...

  • A Synthetic Adjuvant to Enhance and Expand Immune Responses to Influenza Vaccines. Coler, Rhea N.; Baldwin, Susan L.; Shaverdian, Narek; Bertholet, Sylvie; Reed, Steven J.; Raman, Vanitha S.; Xiuhua Lu; DeVos, Joshua; Hancock, Kathy; Katz, Jacqueline M.; Vedvick, Thomas S.; Duthie, Malcolm S.; Clegg, Christopher H.; Van Hoeven, Neal; Reed, Steven G. // PLoS ONE;2010, Vol. 5 Issue 10, p1 

    Safe, effective adjuvants that enhance vaccine potency, including induction of neutralizing Abs against a broad range of variant strains, is an important strategy for the development of seasonal influenza vaccines which can provide optimal protection, even during seasons when available vaccines...

  • Systems biology of vaccination for seasonal influenza in humans. Nakaya, Helder I; Wrammert, Jens; Lee, Eva K; Racioppi, Luigi; Marie-Kunze, Stephanie; Haining, W Nicholas; Means, Anthony R; Kasturi, Sudhir P; Khan, Nooruddin; Li, Gui-Mei; McCausland, Megan; Kanchan, Vibhu; Kokko, Kenneth E; Li, Shuzhao; Elbein, Rivka; Mehta, Aneesh K; Aderem, Alan; Subbarao, Kanta; Ahmed, Rafi; Pulendran, Bali // Nature Immunology;Aug2011, Vol. 12 Issue 8, p786 

    Here we have used a systems biology approach to study innate and adaptive responses to vaccination against influenza in humans during three consecutive influenza seasons. We studied healthy adults vaccinated with trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine...

  • Stabilization of HAC1 Influenza Vaccine by Spray Drying: Formulation Development and Process Scale-Up. Zhu, Changcheng; Shoji, Yoko; McCray, Scott; Burke, Michael; Hartman, Caitlin; Chichester, Jessica; Breit, Jeff; Yusibov, Vidadi; Chen, Dexiang; Lal, Manjari // Pharmaceutical Research;Nov2014, Vol. 31 Issue 11, p3006 

    Purpose: Stable vaccines with long shelf lives and reduced dependency on the cold chain are ideal for stockpiling and rapid deployment during public emergencies, including pandemics. Spray drying is a low-cost process that has potential to produce vaccines stable at a wide range of temperatures....

  • Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain. Okamatsu, Masatoshi; Sakoda, Yoshihiro; Hiono, Takahiro; Yamamoto, Naoki; Kida, Hiroshi // Virology Journal;2013, Vol. 10 Issue 1, p1 

    Background: The pandemic 2009 (H1N1) influenza virus has spread throughout the world and is now causing seasonal influenza. To prepare for the emergence of pandemic influenza, we have established a library of virus strains isolated from birds, pigs, and humans in global surveillance studies....

  • Cross-protective immunity against influenza A/H1N1 virus challenge in mice immunized with recombinant vaccine expressing HA gene of influenza A/H5N1 virus. Song Yang; Shumeng Niu; Zhihua Guo; Ye Yuan; Kun Xue; Sinan Liu; Hong Jin // Virology Journal;2013, Vol. 10 Issue 1, p1 

    Background: Influenza virus undergoes constant antigenic evolution, and therefore influenza vaccines must be reformulated each year. Time is necessary to produce a vaccine that is antigenically matched to a pandemic strain. A goal of many research works is to produce universal vaccines that can...

  • Prokaryote-expressed M2e protein improves H9N2 influenza vaccine efficacy and protection against lethal influenza a virus in mice. Eun-Ha Kim; Jun-Han Lee; Pascua, Philippe Noriel Q.; Min-Suk Song; Yun-Hee Baek; Hyeok-il Kwon; Su-Jin Park; Gyo-Jin Lim; Arun Decano; Chowdhury, Mohammed Y. E.; Su-Kyung Seo; Man Ki Song; Chul-Joong Kim; Young-Ki Choi // Virology Journal;2013, Vol. 10 Issue 1, Special section p1 

    Background: Influenza vaccines are prepared annually based on global epidemiological surveillance data. However since there is no method by which to predict the influenza strain that will cause the next pandemic, the demand to develop new vaccination strategies with broad cross-reactivity...

  • MVA Vectors Expressing Conserved Influenza Proteins Protect Mice against Lethal Challenge with H5N1, H9N2 and H7N1 Viruses. Hessel, Annett; Savidis-Dacho, Helga; Coulibaly, Sogue; Portsmouth, Daniel; Kreil, Thomas R.; Crowe, Brian A.; Schwendinger, Michael G.; Pilz, Andreas; Barrett, P. Noel; Falkner, Falko G.; Schäfer, Birgit // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    Background: The availability of a universal influenza vaccine able to induce broad cross-reactive immune responses against diverse influenza viruses would provide an alternative to currently available strain-specific vaccines. We evaluated the ability of vectors based on modified vaccinia virus...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics