Fatal 2009 pandemic influenza A (H1N1) in a bone marrow transplant recipient

Abdo, Anselmo; Alfonso, Carlos; Diaz, Guillermo; Wilford, Mario; Rocha, Maykel; Verdecia, Niurka
February 2011
Journal of Infection in Developing Countries;Feb2011, Vol. 5 Issue 2, p131
Academic Journal
Conditions characterized by immunosuppression have been recently reported as risk factors for severe novel swine-origin influenza A (H1N1) virus (S-OIV) infection during the current 2009 pandemic. We report clinical and virological findings, antiviral therapy, and post- mortem study of S-OIV in an adult bone marrow transplant recipient. The viral genome was amplified by real time reverse transcriptase polymerase chain reaction (RT-PCR) from a nasopharyngeal swab specimen. The patient developed acute respiratory distress syndrome, septic shock, and eventually succumbed with a severe pulmonary haemorrhage. To the best of our knowledge, the entire clinical/therapy management and pathological examination in a transplant recipient infected with the S-OIV has not been previously documented. The fatal ending in this bone marrow transplant recipient supports recommendations that call for education measures, S-OIV vaccination, early diagnosis and aggressive treatment in the transplant population.


Related Articles

  • Full-genome analysis of avian influenza virus H9N2 from Bangladesh reveals internal gene reassortments with two distinct highly pathogenic avian influenza viruses. Parvin, Rokshana; Heenemann, Kristin; Halami, Mohammad; Chowdhury, Emdadul; Islam, M.; Vahlenkamp, Thomas // Archives of Virology;Jul2014, Vol. 159 Issue 7, p1651 

    Low-pathogenic avian influenza viruses (LPAIVs) of subtype H9N2 have become widespread in poultry in many Asian countries with relevance to respiratory diseases of multifactorial origin. In Bangladesh, LPAIVs of subtype H9N2 co-circulate simultaneously with highly pathogenic avian influenza...

  • Detection and characterization of porcine caliciviruses in Italy. Di Bartolo, Ilaria; Tofani, Silvia; Angeloni, Giorgia; Ponterio, Eleonora; Ostanello, Fabio; Ruggeri, Franco // Archives of Virology;Sep2014, Vol. 159 Issue 9, p2479 

    Porcine noroviruses and sapoviruses have been sporadically reported in European countries, and more rarely in Italy. In this study, stools samples were collected from both asymptomatic and diarrheic pigs from northern Italy and were screened for caliciviruses by RT-PCR. Sapoviruses were detected...

  • Molecular detection and characterization of bovine viral diarrhea virus in Mongolian cattle and yaks. Ochirkhuu, Nyamsuren; Konnai, Satoru; Odbileg, Raadan; Odzaya, Battogtokh; Gansukh, Shura; Murata, Shiro; Ohashi, Kazuhiko // Archives of Virology;Aug2016, Vol. 161 Issue 8, p2279 

    Bovine viral diarrhea virus (BVDV) is classified into two species, namely, Bovine viral diarrhea virus 1 and Bovine viral diarrhea virus 2, and affects cattle worldwide, resulting in significant economic loss. The prevalence of BVDV-1 and BVDV-2 infections and its genotypes in Mongolian animals...

  • Phylogenetic and molecular characterization of coxsackievirus A24 variant isolates from a 2010 acute hemorrhagic conjunctivitis outbreak in Guangdong, China.  // Virology Journal;2012, Vol. 9 Issue 1, p41 

    The article discusses a study which analyzed phylogenetic and molecular characterization of coxsackievirus A24 variant isolates from a 2010 acute hemorrhagic conjunctivitis outbreak in Guangdong, China. As part of the study, full nucleotide sequences for four representative isolates in 2010 and...

  • Infectivity and complete nucleotide sequence of cucumber fruit mottle mosaic virus isolate Cm cDNA. Rhee, Sun-Ju; Hong, Jin-Sung; Lee, Gung // Archives of Virology;Jul2014, Vol. 159 Issue 7, p1807 

    Three isolates of cucumber fruit mottle mosaic virus (CFMMV) were collected from melon, cucumber, and pumpkin plants in Korea. A full-length cDNA clone of CFMMV-Cm (melon isolate) was produced and evaluated for infectivity after T7 transcription in vitro (pT7CF-Cm). The complete CFMMV genome...

  • An Influenza A/H1N1/2009 Hemagglutinin Vaccine Produced in Escherichia coli. Aguilar-Yáñez, José M.; Portillo-Lara, Roberto; Mendoza-Ochoa, Gonzalo I.; García-Echauri, Sergio A.; López-Pacheco, Felipe; Bulnes-Abundis, David; Salgado-Gallegos, Johari; Lara-Mayorga, Itzel M.; Webb-Vargas, Yenny; León-Angel, Felipe O.; Rivero-Aranda, Ramón E.; Oropeza-Almazán, Yuriana; Ruiz-Palacios, Guillermo M.; Zertuche-Guerra, Manuel I.; DuBois, Rebecca M.; White, Stephen W.; Schultz-Cherry, Stacey; Russell, Charles J.; Alvarez, Mario M. // PLoS ONE;2010, Vol. 5 Issue 7, p1 

    Background: The A/H1N1/2009 influenza pandemic made evident the need for faster and higher-yield methods for the production of influenza vaccines. Platforms based on virus culture in mammalian or insect cells are currently under investigation. Alternatively, expression of fragments of the...

  • Surveillance of pathogens causing gastroenteritis and characterization of norovirus and sapovirus strains in Shenzhen, China, during 2011. Wu, Wei; Yang, Hong; Zhang, Hai-long; Xian, Hui-Xia; Yao, Xiang-Jie; Zhao, De-Jian; Chen, Long; Shu, Bai-hua; Zhou, Yi-kai; He, Ya-Qing // Archives of Virology;Aug2014, Vol. 159 Issue 8, p1995 

    Viral gastroenteritis is one of the most common diseases in humans, and it is primarily caused by rotaviruses (RVs), astroviruses (AstVs), adenoviruses (AdVs), noroviruses (NoVs), and sapoviruses (SaVs). In this study, we determined the distribution of viral gastroenteritis and human calicivirus...

  • Detection of dengue-4 virus in pune, western india after an absence of 30 years - its association with two severe cases. Cecilia, Dayaraj; Kakade, Mahadeo B.; Bhagat, Asha B.; Vallentyne, Joyprashant; Singh, Anand; Patil, Jayashri A.; Todkar, Shankar M.; Varghese, Sunitha B.; Shah, Paresh S. // Virology Journal;2011, Vol. 8 Issue 1, p46 

    Background: Difference in severity of dengue outbreaks has been related to virus serotype, genotype and clades within genotypes. Till the 1980 s, India and Sri Lanka reported low number of dengue hemorrhagic fever (DHF) cases despite circulation of all four serotypes of dengue virus (DENV)....

  • Acute Hemorrhagic Conjunctivitis Outbreaks Caused by Coxsackievirus A24v -- Uganda and Southern Sudan, 2010. Wamala, J.; Makumbi, I.; Mugagga, M.; Bakamutumaho, B.; Wasike, S.; Downing, R.; Kirbak, A. Laku; Ugiji, T.; Hassen, J. John; Abias, A. Gordon; Lagu, J.; Atem, N.; Yona, K. M.; Abubakar, A.; Njenga, M. K.; Gikundi, S.; Nderitu, L.; Rogers, S. L.; Oberste, M. S.; Pallansch, M. // MMWR: Morbidity & Mortality Weekly Report;8/20/2010, Vol. 59 Issue 32, p1024 

    The article focuses on acute hemorrhagic conjunctivitis (AHC) outbreaks caused by coxsackievirus A24v in Uganda and Southern Sudan in 2010. As of August, reported cases of AHC in Uganda and Southern Sudan reached 6, 818 and 428, respectively. Reverse transcription-polymerase chain reaction...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics