TITLE

Hormones, Neurons and Anxiety

PUB. DATE
September 2011
SOURCE
BioWorld Today;9/6/2011, Vol. 22 Issue 172, Special section p2
SOURCE TYPE
Periodical
DOC. TYPE
Article
ABSTRACT
The article discusses a study, conducted by researchers from the German Max Planck Institute for Psychiatry, which presented new insights into corticotropin-releasing hormone receptor 1 (CRHR1).
ACCESSION #
65321020

 

Related Articles

  • Corticotropin-Releasing Factor Receptor Antagonists in Affective Disorders and Drug Dependence - An Update. Steckler, Thomas; Dautzenberg, Frank M. // CNS & Neurological Disorders - Drug Targets;2006, Vol. 5 Issue 2, p147 

    Dysfunctioning of corticotropin-releasing factor (CRF) and its receptors (CRF1 and CRF2) has been linked to the development of stress-related disorders, such as affective disorders and drug abuse. The molecular characterization of CRF1 and CRF2 receptors and their splice variants has generated...

  • The Role of Corticotropin-Releasing Hormone in the Pathophysiology of Depression: Therapeutic Implications. Lloyd, R. Brett; Nemeroff, Charles B. // Current Topics in Medicinal Chemistry;Mar2011, Vol. 11 Issue 6, p609 

    Stress responses have been posited to be a key component of mental health and disease by playing essential roles both in normal adaptive processes and maladaptive physiological responses that in part underlie the pathogenesis of certain subtypes of mood and anxiety disorders. Early research...

  • CRF Receptor Antagonists: Utility in Research and Clinical Practice. Chatzaki, E.; Minas, V.; Zoumakis, E.; Makrigiannakis, A. // Current Medicinal Chemistry;2006, Vol. 13 Issue 23, p2751 

    CRF, CRF-related peptides and CRF receptors constitute a complex physiological system which has a key role in facilitating the adaptation of the organism to the stressful stimuli of the environment. The behavioral, endocrine, autonomic and immune branches of stress response are considered to be...

  • Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919). Post, Anke; Ohl, Frauke; Almeida, Osborne F. X.; Binder, Elisabeth B.; Rücker, Monika; Welt, Sandra; Binder, Elke; Holsboer, Florian; Sillaber, Inge // Psychopharmacology;Jun2005, Vol. 180 Issue 1, p150 

    Presents a study which discussed the molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone (CRH) receptor 1 antagonist NBI30775. Role of the neuropeptide CRH; Link between the hyperactivity of the hypothalamic-pituitary-adrenal axis with mood and...

  • Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans. Licinio, J.; O'Kirwan, F.; Irizarry, K.; Merriman, B.; Thakur, S.; Jepson, R.; Lake, S.; Tantisira, K. G.; Weiss, S. T.; Wong, M.-L. // Molecular Psychiatry;Dec2004, Vol. 9 Issue 12, p1075 

    There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression. CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety. We...

  • Behavioural genetics: Dipsomaniac mice? López, Juan Carlos // Nature Reviews Genetics;Jun2002, Vol. 3 Issue 6, p408 

    Discusses research on the enhanced and delayed stress-induced alcohol drinking in mice lacking functional corticotropin-releasing hormone (CRH). Reference to a study by L. Sillaber and colleagues published in the 2002 issue of "Science" journal; Influence of stress on alcohol intake; CRH...

  • The CRF Receptor Structure, Function and Potential for Therapeutic Intervention. Grigoriadis, D.E.; Haddach, M.; Ling, N.; Saunders, J. // Current Medicinal Chemistry - Central Nervous System Agents;May2001, Vol. 1 Issue 1, p63 

    Two distinct sub-types of receptor encoded by separate genes have been described to date, CRF1 and CRF2, and they belong to the Class-B subdivision within the G-protein coupled receptor (GPCR) super family. All known CRF receptors positively regulate the accumulation of cAMP in response to CRF...

  • Corticotropin-Releasing Factor Binding Protein - A Ligand Trap? Jahn, Olaf; Radulovic, Jelena; Stiedl, Oliver; Tezval, Hossein; Eckart, Klaus; Spiess, Joachim // Mini Reviews in Medicinal Chemistry;Oct2005, Vol. 5 Issue 10, p953 

    The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of...

  • Time course of hypothalamic-pituitary-adrenocortical axis activity during treatment with reboxetine and mirtazapine in depressed patients. Schüle, Cornelius; Baghai, Thomas; Eser, Daniela; Zwanzger, Peter; Jordan, Martina; Buechs, Renate; Rupprecht, Rainer // Psychopharmacology;Jul2006, Vol. 186 Issue 4, p601 

    Rationale: In healthy subjects, cortisol and ACTH secretion are acutely stimulated by reboxetine and inhibited by mirtazapine. However, it was not investigated so far whether reboxetine and mirtazapine may also differ in their impact on hypothalamic-pituitary-adrenocortical (HPA) axis activity...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics