Drug resistance in malaria

Parija, SC; Praharaj, I
July 2011
Indian Journal of Medical Microbiology;Jul2011, Vol. 29 Issue 3, p243
Academic Journal
Antimalarial chemotherapy is an important component of all malaria control programmes throughout the world. This is especially so in light of the fact that there are no antimalarial vaccines which are available for clinical use at present. Emergence and spread of malaria parasites which are resistant to many of the available antimalarials today is, therefore, a major cause for concern. Till date, resistance to all groups of antimalarials excluding artemisinin has been reported. In recent years, in vitro resistance to even artemisinin has been described. While resistance to antibacterial agents has come to prominence as a clinical problem in recent years, antiparasitic resistance in general and antimalarial resistance in particular has not received much attention, especially in the Indian scenario. The present review deals with commonly used antimalarial drugs and the mechanisms of resistance to them. Various methods of detecting antimalarial resistance and avoiding the same have also been dealt with. Newer parasite targets which can be used in developing newer antimalarial agents and antimalarials obtained from plants have also been mentioned.


Related Articles

  • Antimicrobial resistance and disease control.  // Veterinary Record: Journal of the British Veterinary Association;3/15/2003, Vol. 152 Issue 11, p314 

    Reports on issues relating to antimicrobial resistance and disease control in Great Britain as discussed during a meeting organized by the Comparative Medicine Section of the Royal Society of Medicine. Threat of multiresistant strains of salmonella introduced through importation of foodstuffs;...

  • Essential Medicines. Schwarte, S.; Ringwald, P.; Mendis, K.; Bosman, A. // WHO Drug Information;2010, Vol. 24 Issue 2, p98 

    Continued use of oral artemisinin-based monotherapy is widely considered as one of the main contributing factors to the development and spread of resistance to artemisinin and its derivatives. Few patients take the full seven–day course of monotherapy required to achieve high cure rates...

  • Surveillance of Travellers: An Additional Tool for Tracking Antimalarial Drug Resistance in Endemic Countries. Gharbi, Myriam; Flegg, Jennifer A.; Pradines, Bruno; Berenger, Ako; Ndiaye, Magatte; Djimdé, Abdoulaye A.; Roper, Cally; Hubert, Véronique; Kendjo, Eric; Venkatesan, Meera; Brasseur, Philippe; Gaye, Oumar; Offianan, André T.; Penali, Louis; Le Bras, Jacques; Guérin, Philippe J.; Study, Members of the French National Reference Center for Imported Malaria // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    Introduction: There are growing concerns about the emergence of resistance to artemisinin-based combination therapies (ACTs). Since the widespread adoption of ACTs, there has been a decrease in the systematic surveillance of antimalarial drug resistance in many malaria-endemic countries. The aim...

  • Embracing ecology to limit antimicrobial resistance. Nicolle, Lindsay; Conly, John M.; MacDonald, Noni // CMAJ: Canadian Medical Association Journal;2/17/2009, Vol. 180 Issue 4, p371 

    The authors reflect on the prevalence of antimicrobial resistance infection in Canada. They cite that the greater the intensity of antimicrobial use, the more rapid the resistance strain occur. They note that appropriate microbial use is the most effective strategy against antimicrobial...

  • Sigurnost hrane i antimikrobna rezistencija. Zdolec, Nevijo // MESO;Jan2011, Vol. 13 Issue 1, p18 

    No abstract available.

  • Implementing a Strategy for Monitoring Inpatient Antimicrobial Use Among Hospitals in the United States. Fridkin, Scott K.; Srinivasan, Arjun // Clinical Infectious Diseases;Feb2014, Vol. 58 Issue 3, p401 

    The Centers for Disease Control and Prevention is pursuing 3 distinct, complementary efforts focused on providing data for action, including facility-level use metrics for benchmarking across comparable patient care settings, national estimates of usage patterns using sentinel surveillance...

  • EC sets out guidance on prudent use of antimicrobials.  // Veterinary Record: Journal of the British Veterinary Association;9/26/2015, Vol. 177 Issue 12, p297 

    The article reports on the guidelines issued by the European Commission (EC) on the use of antimicrobials in veterinary medicine, which aim to address the principles of prudent use and development and implementation of national strategies to combat antimicrobial resistance (AMR). The ultimate...

  • Antimicrobial resistance - moving forward? Lomazzi, Marta; Moore, Michael; Johnson, April; Balasegaram, Manica; Borisch, Bettina // BMC Public Health;7/2/2019, Vol. 19 Issue 1, pN.PAG 

    Background: When microorganisms (such as bacteria or viruses) are highly exposed to antimicrobial drugs, they can develop the capacity to defeat the drugs designed to eradicate them. Long-term accumulation of adaptations to survive drug exposure can lead to the development of...

  • Rise in Highly Resistant S. pneumoniae Seen in Massachusetts.  // Clinical Infectious Diseases;12/15/2007, Vol. 45 Issue 12, piii 

    The article reports on the increase in serotype 19A Streptococcus pneumoniae, which is often resistant to multiple antibiotics, occurred in Massachusetts. Researchers revealed that the overall rates of invasive pneumococcal disease held steady during the study period. At the same time, a drop...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics