Antimicrobial resistance in typhoidal salmonellae

Harish, BN; Menezes, GA
July 2011
Indian Journal of Medical Microbiology;Jul2011, Vol. 29 Issue 3, p223
Academic Journal
Infections with Salmonella are an important public health problem worldwide. On a global scale, it has been appraised that Salmonella is responsible for an estimated 3 billion human infections each year. The World Health Organization (WHO) has estimated that annually typhoid fever accounts for 21.7 million illnesses (217,000 deaths) and paratyphoid fever accounts for 5.4 million of these cases. Infants, children, and adolescents in south central and South-eastern Asia experience the greatest burden of illness. In cases of enteric fever, including infections with S. Typhi and S. Paratyphi A and B, it is often necessary to commence treatment before the results of laboratory sensitivity tests are available. Hence, it is important to be aware of options and possible problems before beginning treatment. Ciprofloxacin has become the first-line drug of choice since the widespread emergence and spread of strains resistant to chloramphenicol, ampicillin, and trimethoprim. There is increase in the occurrence of strains resistant to ciprofloxacin. Reports of typhoidal salmonellae with increasing minimum inhibitory concentration (MIC) and resistance to newer quinolones raise the fear of potential treatment failures and necessitate the need for new, alternative antimicrobials. Extendedspectrum cephalosporins and azithromycin are the options available for the treatment of enteric fever. The emergence of broad spectrum â-lactamases in typhoidal salmonellae constitutes a new challenge. Already there are rare reports of azithromycin resistance in typhoidal salmonellae leading to treatment failure. This review is based on published research from our centre and literature from elsewhere in the world. This brief review tries to summarize the history and recent trends in antimicrobial resistance in typhoidal salmonellae.


Related Articles

  • Bacteremia and Antimicrobial Drug Resistance over Time, Ghana. Groß, Uwe; Amuzu, Sylvarius K.; de Ciman, Ring; Kassimova, Iparkhan; Groß, Lisa; Rabsch, Wolfgang; Rosenberg, Ulrike; Schulze, Marco; Stich, August; Zimmermann, Ortrud // Emerging Infectious Diseases;Oct2011, Vol. 17 Issue 10, p1879 

    Bacterial distribution and antimicrobial drug resistance were monitored in patients with bacterial bloodstream infections in rural hospitals in Ghana. In 2001-2002 and in 2009, Salmonella enterica serovar Typhi was the most prevalent pathogen. Although most S. enterica serovar Typhi isolates...

  • Ciprofloxacin Resistance and Gonorrhea Incidence Rates in 17 Cities, United States, 1991-2006. Chesson, Harrell W.; Kirkcaldy, Robert D.; Gift, Thomas L.; Owusu-Edusei Jr., Kwame; Weinstock, Hillard S. // Emerging Infectious Diseases;Apr2014, Vol. 20 Issue 4, p612 

    Antimicrobial drug resistance can hinder gonorrhea prevention and control efforts. In this study, we analyzed historical ciprofloxacin resistance data and gonorrhea incidence data to examine the possible effect of antimicrobial drug resistance on gonorrhea incidence at the population level. We...

  • Reevaluating Fluoroquinolone Breakpoints for Salmonella enterica Serotype Typhi and for Non-Typhi Salmonellae. Crump, John A.; Barrett, Timothy J.; Nelson, Jennifer T.; Angulo, Frederick J. // Clinical Infectious Diseases;7/1/2003, Vol. 37 Issue 1, p75 

    Salmonella enterica infections cause considerable morbidity and mortality worldwide. Antimicrobial therapy may be lifesaving for patients with extraintestinal infections with S. enterica serotype Typhi or non-Typhi salmonellae. Because antimicrobial resistance to several classes of traditional...

  • Antimicrobial resistance and disease control.  // Veterinary Record: Journal of the British Veterinary Association;3/15/2003, Vol. 152 Issue 11, p314 

    Reports on issues relating to antimicrobial resistance and disease control in Great Britain as discussed during a meeting organized by the Comparative Medicine Section of the Royal Society of Medicine. Threat of multiresistant strains of salmonella introduced through importation of foodstuffs;...

  • Global Health. The World Health Organization's Sixty-Eighth World Health Assembly: Updates and Opportunities. Ferguson, Stephanie L. // Nursing Economic$;Jul/Aug2015, Vol. 33 Issue 4, p236 

    The article presents updates and opportunities for nurses from the 68th World Health Assembly (WHA) of the World Health Organization (WHO) held in Geneva, Switzerland in May 2015. It mentions the role of WHA as the decision-making body of the WHO, work processes at the WHA including plenary...

  • Antimicrobial susceptibility and multi-drug resistance of Salmonella enterica subspecies enterica serovars in Sudan. Elmadiena, Mayha; Hussein, Adil; Muckle, Catherine; Cole, Linda; Wilkie, Elizabeth; Mistry, Ketna; Perets, Ann // Tropical Animal Health & Production;Jun2013, Vol. 45 Issue 5, p1113 

    This study was undertaken to determine the antimicrobial resistance patterns of Salmonella enterica subspecies enterica recovered from human, food, water, and animal samples collected in Khartoum State, Sudan. A total of 64 Salmonella isolates belonging to 28 different serovars were tested for...

  • Systemic and extraintestinal forms of human infection due to non-typhoid salmonellae in Bulgaria, 2005-2010. Asseva, G.; Petrov, P.; Ivanova, K.; Kantardjiev, T. // European Journal of Clinical Microbiology & Infectious Diseases;Nov2012, Vol. 31 Issue 11, p3217 

    The purpose of this investigation was to review the clinical cases diagnosed as systemic or extraintestinal salmonellosis between 2005 and 2010 in Bulgaria, to determine the antimicrobial resistance of the causative salmonellae, and to analyze the pulsed field gel electrophoresis (PFGE) profiles...

  • Antimicrobial Susceptibility Pattern and Characterization of Ciprofloxacin Resistant Salmonella enterica Serovar Typhi Isolates in Kerala, South India. Ayana, N.; Surekha, K. // Research Journal of Microbiology;2008, Vol. 3 Issue 11, p654 

    The aim of the study was to determine antimicrobial susceptibility pattern and to examine the mechanism of increasing quinolone resistance of S. typhi isolates in Kerala, South India. Ciprofloxacin resistant isolates were characterized by mutation analysis of quinolone resistance determining...

  • Antimicrobial resistance in Salmonella enterica serovar Enteritidis in Morocco. Ohmani, Farida; Khedid, Khadija; Britel, Saad; Qasmaoui, Aicha; Charof, Reda; Filali-Maltouf, Abdelkarim; Aouad, Rajae El // Journal of Infection in Developing Countries;Dec2010, Vol. 4 Issue 12, p804 

    Introduction: Salmonella enterica is recognised worldwide as one of the major agents of human gastrointestinal infections. The aim of the present work is to ascertain the antimicrobial susceptibilities of 150 Salmonella enterica serovar Enteritidis isolates from humans in Morocco during the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics