TITLE

Effects of combined balanced colloid and crystalloid on rotational thromboelastometry in vitro

AUTHOR(S)
Lindroos, A-C; Schramko, AA; Niiya, T; Suojaranta-Ylinen, RT; Niemi, TT
PUB. DATE
September 2011
SOURCE
Perfusion;Sep2011, Vol. 26 Issue 5, p422
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Our objective was to investigate the in vitro effects of a totally balanced fluid concept on whole blood coagulation. Venous blood from 12 healthy volunteers was diluted by 20% and 40% with a combination of an equal amount of colloid (balanced or unbalanced 6% HES 130/0.4, or 4% gelatin) and crystalloid (balanced or unbalanced Ringer’s acetate). Blood samples were analyzed with rotational thromboelastometry (ROTEM®).The initiation of coagulation was delayed in all dilutions except for the 20 vol% gelatin-dilution. In the extrinsic activation test, maximum clot firmness was decreased and clot formation time prolonged after 40 vol% hemodilution with a balanced Ringer’s/unbalanced HES combination, more than in the corresponding gelatin hemodilution. In the fibrin-based test, after both 20- and 40 vol% hemodilution with unbalanced Ringer’s/gelatin solution, maximum clot firmness was significantly stronger than in the Ringer’s/HES-combinations.The combination of balanced colloid and crystalloid has similar coagulation effects in vitro as their respective combination of unbalanced solutions.
ACCESSION #
65285378

 

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