TITLE

Cocaine- and amphetamine-regulated transcript promotes the differentiation of mouse bone marrow-derived mesenchymal stem cells into neural cells

PUB. DATE
January 2011
SOURCE
BMC Neuroscience;2011, Vol. 12 Issue 1, p67
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on a study on the promotion of the differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs) into neural cells by cocaine- and amphetamine-regulated transcript (CART). It describes the study on mouse in which MSCs from bone marrow were isolated and identified, co-cultured with CART, and immunofluorescence analysis was done on differentiated BM-MSCs. The study showed that CART can promote the differentiation of BM-MSCs into neural cells.
ACCESSION #
65243783

 

Related Articles

  • Relevance of deep decortication and vascularization in a case of post-traumatic femoral non-union treated with grafts, platelet gel and bone marrow stromal cells. Dallari, Dante; Savarino, Lucia; Greco, Michelina; Rani, Nicola; Piccolo, Nicolandrea; Baldini, Nicola // Knee Surgery, Sports Traumatology, Arthroscopy;Sep2012, Vol. 20 Issue 9, p1834 

    Purpose: A male patient suffering from non-union of the femoral diaphysis after a traumatic fracture was treated with deep decortication and grafted with lyophilized bone, platelet gel (PG) and autologous bone marrow stromal cells (BMSCs). After 40 days from surgery, he was re-operated, due to...

  • The Effect of miR-210 Up-regulation on Proliferation and Survival of Mouse Bone Marrow Derived Mesenchymal Stem Cell. Minayi, Neda; Alizadeh, Shaban; Dargahi, Hosein; Soleimani, Masoud; Khatib, Zahra Kashani; tayebi, behnoosh; Mohammadian, Mozhde; Alijani, Sadegh; Karami, Farshid // International Journal of Hematology-Oncology & Stem Cell Researc;Jan2014, Vol. 8 Issue 1, p15 

    Background: Bone marrow derived mesenchymal stem cells (MSCs) are a population of multipotent progenitors which have the capacity of proliferation and differentiation into mesenchymal lineage cells. Hypoxia could promote the proliferation of MSCs. Micro-RNAs are endogenous RNAs that can play an...

  • The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells. Igarashi, Hidemitsu; Akahoshi, Noriyuki; Ohto-Nakanishi, Takayo; Yasuda, Daisuke; Ishii, Satoshi // Scientific Reports;6/19/2015, p11410 

    Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that acts through G protein-coupled receptors (LPA1-6). Although several biological roles of LPA4 are becoming apparent, its role in hematopoiesis has remained unknown. Here, we show a novel regulatory role for LPA4 in hematopoiesis....

  • Distinct Roles of Bcl-2 and Bcl-Xl in the Apoptosis of Human Bone Marrow Mesenchymal Stem Cells during Differentiation. Oliver, Lisa; Hue, Erika; Rossignol, Julien; Bougras, Gwenola; Hulin, Philippe; Naveilhan, Philippe; Heymann, Dominique; Lescaudron, Laurent; Vallette, François M. // PLoS ONE;2011, Vol. 6 Issue 5, p1 

    Background: Adult mesenchymal stem cells (MSCs) can be maintained over extended periods of time before activation and differentiation. Little is known about the programs that sustain the survival of these cells. Principal Findings: Undifferentiated adult human MSCs (hMSCs) did not undergo...

  • Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study. RENHONG HE; JIANZHONG FAN // Molecular Medicine Reports;2014, Vol. 10 Issue 5, p2427 

    Poor viability of transplanted bone marrow mesenchymal stem cells (BMSCs) is well-known, but developing methods for enhancing the viability of BMSCs requires further investigation. The aim of the present study was to elucidate the effects of infrasound on the proliferation and apoptosis of...

  • Mesenchymal Stem Cells and Articular Cartilage Repair: Clinical Studies and Future Direction. Punwar, Shahid; Khan, Wasim S. // Open Orthopaedics Journal;2011 Special Issue 002, Vol. 5 Issue S2, p296 

    Cartilage is frequently injured but shows little capacity for repair. Current treatment options include the use of procedures that stimulate repair through the stimulation of subchondral bone marrow and result in the formation of fibrocartilage. There is considerable interest in the use of...

  • Human Bone Marrow-derived Mesenchymal Stem Cell: A Source for Cell-Based Therapy. Ayatollahi, M.; Geramizadeh, B.; Zakerinia, M.; Ramzi, M.; Yaghobi, R.; Hadadi, P.; Rezvani, A. R.; Aghdai, M.; Azarpira, N.; Karimi, H. // International Journal of Organ Transplantation Medicine;2012, Vol. 3 Issue 1, p32 

    Background: The ability of mesenchymal stem cells (MSCs) to differentiate into many cell types, and modu-late immune responses, makes them an attractive therapeutic tool for cell transplantation and tissue engineering. Objective: This project was designed for isolation, culture, and...

  • The myofibroblast, multiple origins for major roles in normal and pathological tissue repair. Micallef, Ludovic; Vedrenne, Nicolas; Billet, Fabrice; Coulomb, Bernard; Darby, Ian A.; Desmoulière, Alexis // Fibrogenesis & Tissue Repair;2012, Vol. 5 Issue Suppl 1, p1 

    Myofibroblasts differentiate, invade and repair injured tissues by secreting and organizing the extracellular matrix and by developing contractile forces. When tissues are damaged, tissue homeostasis must be re-established, and repair mechanisms have to rapidly provide harmonious mechanical...

  • Regulation of hematopoietic and leukemic stem cells by the immune system. Riether, C; Schürch, C M; Ochsenbein, A F // Cell Death & Differentiation;Feb2015, Vol. 22 Issue 2, p187 

    Hematopoietic stem cells (HSCs) are rare, multipotent cells that generate via progenitor and precursor cells of all blood lineages. Similar to normal hematopoiesis, leukemia is also hierarchically organized and a subpopulation of leukemic cells, the leukemic stem cells (LSCs), is responsible for...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics