TITLE

Interrelation of Cell Apoptosis and Proliferation in the Thymus during Its Involution

AUTHOR(S)
Linkova, N.; Polyakova, V.; Kvetnoy, I.
PUB. DATE
August 2011
SOURCE
Bulletin of Experimental Biology & Medicine;Aug2011, Vol. 151 Issue 4, p460
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In people over 60 years, thymocytes contain proliferation protein Ki67 and proapoptotic protein P53. During aging, apoptosis of thymus cell prevails over proliferation, though thymocytes retain proliferative capacity even in long-livers.
ACCESSION #
65181652

 

Related Articles

  • Changes in Apoptosis and Cell Proliferation in Human Pineal Gland during Aging. Polyakova, V. O.; Linkova, N. S.; Pichugin, S. A. // Bulletin of Experimental Biology & Medicine;Feb2011, Vol. 150 Issue 4, p468 

    Immunohistochemical analysis of the expression of proapoptotic protein P53 and proliferation protein Ki-67 in human pineal gland showed that in people over 60 years pinealocyte proliferation is virtually absent. Moreover, pinealocyte apoptosis is more pronounced in elderly, whereas in senile and...

  • Age-Related Features of Expression of Cell Renewal Factors in the Intestinal Peyer's Patches. Grabezhev, L. A.; Sevostjanova, N. N.; Kolmakov, A. N.; Konovalov, S. S.; Polyakova, V. O.; Kvetnoy, I. M. // Bulletin of Experimental Biology & Medicine;Feb2011, Vol. 150 Issue 4, p465 

    Immunohistochemical study with markers of proapoptotic protein P53 and proliferation protein Ki-67 revealed an age-related decrease in proliferative activity of lymphocyte in the intestinal Peyer's patches and an increase in the ratio of apoptotic cells in humans. These changes aggravate atrophy...

  • p53-Induced Apoptosis and Inhibitors of p53. Nayak, Surendra Kumar; Panesar, Paramjit Singh; Kumar, Harish // Current Medicinal Chemistry;Jul2009, Vol. 16 Issue 21, p2627 

    Protein p53 is a key player in mitochondrial mediated apoptotic cell death and excess p53 activity has been implicated in many disease states such athrosclerosis, diabetes, osteoarthritis, Alzheimer's disease, Parkinson's disease, Huntington's disease, AIDS, P. falciparum and S. typhimurium...

  • Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pathway. Tinel, Antoine; Janssens, Sophie; Lippens, Saskia; Cuenin, Solange; Logette, Emmanuelle; Jaccard, Bastienne; Quadroni, Manfredo; Tschopp, Jürg // EMBO Journal;1/10/2007, Vol. 26 Issue 1, p197 

    Upon DNA damage, a complex called the PIDDosome is formed and either signals NF-κB activation and thus cell survival or alternatively triggers caspase-2 activation and apoptosis. PIDD (p53-induced protein with a death domain) is constitutively processed giving rise to a 48-kDa N-terminal...

  • Inactivation of HAUSP in vivo modulates p53 function. Kon, N.; Kobayashi, Y.; Li, M.; Brooks, C. L.; Ludwig, T.; Gu, W. // Oncogene;3/4/2010, Vol. 29 Issue 9, p1270 

    Hausp is a deubiquitinase that has been shown to regulate the p53–Mdm2 pathway. Cotransfection of p53 and Hausp stabilizes p53 through the removal of ubiquitin moieties from polyubiquitinated p53. Interestingly, knockout or RNA interference-mediated knockdown of Hausp in human cells also...

  • p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Kruiswijk, Flore; Labuschagne, Christiaan F.; Vousden, Karen H. // Nature Reviews Molecular Cell Biology;Jul2015, Vol. 16 Issue 7, p393 

    The function of p53 as a tumour suppressor has been attributed to its ability to promote cell death or permanently inhibit cell proliferation. However, in recent years, it has become clear that p53 can also contribute to cell survival. p53 regulates various metabolic pathways, helping to balance...

  • Senescence: A family trait. McCarthy, Nicola // Nature Reviews Cancer;Jan2010, Vol. 10 Issue 1, p8 

    The article presents a study on the tumour suppressing tendency of p73 and p63, siblings of p53 which is known to suppress tumour development. It states that p63 is expressed in ΔNp63 isoforms which promote proliferation while TAp63 isoforms induce apoptosis. It notes that the induction of...

  • Regulation of MDM2 Stability After DNA Damage. Li, Jiaqi; Kurokawa, Manabu // Journal of Cellular Physiology;Oct2015, Vol. 230 Issue 10, p2318 

    Cells in our body are constantly exposed to various stresses and threats to their genomic integrity. The tumor suppressor protein p53 plays a critical role in successful defense against these threats by inducing apoptotic cell death or cell cycle arrest. In unstressed conditions, p53 levels and...

  • P63 regulates tubular formation via epithelial-to-mesenchymal transition. Zhang, Y; Yan, W; Chen, X // Oncogene;3/20/2014, Vol. 33 Issue 12, p1548 

    P63, a p53 family member, is expressed as TA and ΔN isoforms. Interestingly, both TAp63 and ΔNp63 are transcription factors, and regulate both common and distinct sets of target genes. p63 is required for survival of some epithelial cell lineages, and lack of p63 leads to loss of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics