TITLE

NEUROPROTECTIVE EFFECT OF VITAMIN C AGAINST PTZ INDUCED APOPTOTIC NEURODEGENERATION IN ADULT RAT BRAIN

AUTHOR(S)
NASEER, MUHAMMAD IMRAN; ULLAH, IKRAM; ULLAH, NAJEEB; HAE YOUNG LEE; EUN WOO CHEON; CHUNG, JONGIL; MYEONG OK KIM
PUB. DATE
July 2011
SOURCE
Pakistan Journal of Pharmaceutical Sciences;Jul2011, Vol. 24 Issue 3, p263
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The present study was designed to observe the effect of PTZ on expression of caspsae-3, and to evaluate the neuroprotective role of vitamin C (vit-C) against PTZ-induced apoptotic neurodegeneration in adult rat brain. We observed that administration of a single conclusive dose of pentylenetetrazol (PTZ 50mg/kg) in adults rats induced epileptic seizure and increased activation of caspase-3 and caused neuronal death. Further, rats were injected with vit-C (250 mg/kg) 30 min before PTZ injection. The protective effect of vit-C against PTZ- induced apoptotic neurodegeneration in adult rat brain was observed using Western blot analysis and Nissl staining. The results showed that conclusive dose of PTZ-induced seizure, increased expression of caspase-3 and neuronal apoptosis in adult rat brain. Whereas, the pretreatment of vit-C along with PTZ showed significantly decreased expression of caspase-3 as compare to control group. Finally, our results indicated that vit-C can prevent some of the deleterious effect of seizure and neuronal degeneration induced by PTZ in adult rat brain.
ACCESSION #
65176087

 

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