TITLE

Study on association of the polymorphic variants of ACE (I/D), AT2R1 (A1166C), TNF-α (G308A), MTHFR (C677T) genes and their combinations with the risk of development of perinatal pathology and gestation reduction

AUTHOR(S)
Gorovenko, N. G.; Kyryachenko, S. P.; Rossokha, Z. I.
PUB. DATE
June 2011
SOURCE
Biopolymers & Cell;Jun2011, Vol. 27 Issue 3, p206
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim. To study the association of the polymorphic variants of ACE (I/D), AT2R1 (A1166C), TNF-á (G308A), MTHFR (C677T) genes and their combinations with the risk of perinatal pathology and gestation reduction. Methods. The polymorphic variants of genes were analyzed by PCR and RFLP in 235 newborns with severe perinatal pathology and 110 clinically healthy term newborns. Results. An increased risk of severe perinatal pathology was associated with such genotypes: DD and ID (ACE), 1166AC, 1166CC (AT2R1), 677CT (MTHFR), 308AA and 308AG (TNF-a), this risk for homozygotes is almost 2-fold higher than for heterozygotes. Reduction of terms of gestation is associated with the genotype 677TT (MTHFR), and resistance to diseases in the perinatal period – with the genotype II (ACE) and 1166AA (AT2R1), 677CC (MTHFR) and the 308GG (TNFa), particularly when com- bined. Conclusions. The identified associations evidence the role of polymorphic variants of ACE, AT2R1, TNF-a, MTHFR genes in the development of severe perinatal pathology and can be used for its early prediction with subsequent correction of treatment.
ACCESSION #
65172256

 

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