Mihăilescu, Alexandra; Riga, Sorin; Riga, Dan; Iamandescu, Ioan-Bradu
June 2011
Romanian Medical Journal;2011, Vol. 58 Issue 2, p92
Academic Journal
Acute and chronic stress have a negative impact on health (in general) and mental health (in particular). The stress/vulnerability binomial initiates the etiopathogenetic cascade stress ↔ impairments ↔ agings ↔ polypathology. Stress genomics demonstrates the importance of vulnerability concept in anxiety and depression disorders in young people. Serotonin transporter gene (SLC6A4), glucocorticoid receptor gene (NR3C1), IL-6 (Interleukin-6) gene, dopamine receptor gene (DRD4), monoamine oxidase A enzyme (MAO-A) gene can cause vulnerability or resistance to distress. Therefore, genomics and stress medicine hold an essential role in public health, mental health, healthy human medicine, in primary prophylaxis of mental disorders, family medicine and personalized medicine.


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