TITLE

Genetic determinants of coronary heart disease: new discoveries and insights from genome-wide association studies

AUTHOR(S)
Patel, Riyaz S.; Shu Ye
PUB. DATE
September 2011
SOURCE
Heart;Sep2011, Vol. 97 Issue 18, p1463
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
With the advent of the Human Genome Project and the genomic era, new tools and methodologies have revitalised genetic research into coronary heart disease (CHD). Unprecedented collaborative efforts are discovering novel risk variants for CHD, with most in hitherto unknown molecular pathways. These findings have stimulated a plethora of follow-up of functional and isk prediction studies to mine this wealth of new data. This review will explore the current state of knowledge of the genetic basis of CHD, with an emphasis on recent genomic studies and how these may eventually lead to the promised goals of new therapeutics and personalized medicine.
ACCESSION #
65162269

 

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