TITLE

Diabetic Peripheral Neuropathy Is Associated With Increased Arterial Stiffness Without Changes in Carotid Intima-Media Thickness in Type 2 Diabetes

AUTHOR(S)
EUN SOOK KIM; SUNG-DAE MOON; HUN-SUNG KIM; DONG JUN LIM; JAE HYOUNG CHO; HYUK SANG KWON; CHUL WOO AHN; KUN HO YOON; MOO IL KANG; BONG YUN CHA; HO YOUNG SON
PUB. DATE
June 2011
SOURCE
Diabetes Care;Jun2011, Vol. 34 Issue 6, p1403
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE--This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima-media thickness (IMT). RESEARCH DESIGN AND METHODS--We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathic symptoms, insensitivity to a 10-g monofilament, abnormal pin-prick sensation, and abnormal current perception threshold. Arterial stiffness was assessed by cardio-ankle vascular index (CAVI), and IMT was assessed by B-mode ultrasonography. RESULTS--Patients with DPN had higher CAVI than those without DPN in multivariateadjusted models, whereas no differences in IMT were observed between patients with and without DPN after adjustment for age and sex. In the multivariate analysis, CAVI was a significant determinant of DPN (odds ratio 1.36 [95% CI 1.13-1.65], P = 0.001). CONCLUSIONS--DPN is significantly associated with arterial stiffness without carotid intimal changes in patients with type 2 diabetes.
ACCESSION #
65099015

 

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