TITLE

Persistence of Individual Variations in Glycated Hemoglobin

AUTHOR(S)
WILSON, DARRELL M.; DONGYUAN XING; JING CHENG; BECK, ROY W.; HIRSCH, IRL; KOLLMAN, CRAIG; LAFFEL, LORI; LAWRENCE, JEAN M.; MAURAS, NELLY; RUEDY, KATRINA J.; TSALIKIAN, EVA; WOLPERT, HOWARD
PUB. DATE
June 2011
SOURCE
Diabetes Care;Jun2011, Vol. 34 Issue 6, p1315
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE--To determine the individual persistence of the relationship between mean sensor glucose (MG) concentrations and hemoglobin A],. (A1C) from the Juvenile Diabetes Re- search Foundation Continuous Glucose Monitoring (CGM) Randomized Trial. RISIAIICH DISIGN AND MITHODS--MG was calculated using CGM data for 3 months before A1C measurements at 3, 6, 9, and 12 months for the CGM group and at 9 and 12 months for the control group. An MG-to-A1C ratio was included in analysis for subjects who averaged ->4 days/week of CGM use. RESULTS--Spearman correlations of the MG-to-A1 C ratio between consecutive visits 3 months apart ranged from 0.70 to 0.79. The correlations for children and youth were slightly smaller than those for adults. No meaningful differences were observed by device type or change in A1C CONCLUSIONS--Individual variations in the rate of hemoglobin glycation are persistent and contribute to the inaccuracy in estimating MGs calculated from A1C levels.
ACCESSION #
65098995

 

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