High throughput optical readout of dense arrays of nanomechanical systems for sensing applications

Martínez, N. F.; Kosaka, P. M.; Tamayo, J.; Ramírez, J.; Ahumada, O.; Mertens, J.; Hien, T. D.; Rijn, C. V.; Calleja, M.
December 2010
Review of Scientific Instruments;Dec2010, Vol. 81 Issue 12, p125109
Academic Journal
We present an instrument based on the scanning of a laser beam and the measurement of the reflected beam deflection that enables the readout of arrays of nanomechanical systems without limitation in the geometry of the sample, with high sensitivity and a spatial resolution of few micrometers. The measurement of nanoscale deformations on surfaces of cm2 is performed automatically, with minimal need of user intervention for optical alignment. To exploit the capability of the instrument for high throughput biological and chemical sensing, we have designed and fabricated a two-dimensional array of 128 cantilevers. As a proof of concept, we measure the nanometer-scale bending of the 128 cantilevers, previously coated with a thin gold layer, induced by the adsorption and self-assembly on the gold surface of several self-assembled monolayers. The instrument is able to provide the static and dynamic responses of cantilevers with subnanometer resolution and at a rate of up to ten cantilevers per second. The instrumentation and the fabricated chip enable applications for the analysis of complex biological systems and for artificial olfaction.


Related Articles

  • Odour Detection Methods: Olfactometry and Chemical Sensors. Brattoli, Magda; de Gennaro, Gianluigi; de Pinto, Valentina; Loiotile, Annamaria Demarinis; Lovascio, Sara; Penza, Michele // Sensors (14248220);2011, Vol. 11 Issue 5, p5290 

    The complexity of the odours issue arises from the sensory nature of smell. From the evolutionary point of view olfaction is one of the oldest senses, allowing for seeking food, recognizing danger or communication: human olfaction is a protective sense as it allows the detection of potential...

  • Flow and evaporation in single micrometer and nanometer scale pipes. Velasco, A. E.; Yang, C.; Siwy, Z. S.; Toimil-Molares, M. E.; Taborek, P. // Applied Physics Letters;7/21/2014, Vol. 105 Issue 3, p1 

    We report measurements of pressure driven flow of fluids entering vacuum through a single pipe of micrometer or nanometer scale diameter. Nanopores were fabricated by etching a single ion track in polymer or mica foils. A calibrated mass spectrometer was used to measure the flow rates of...

  • Nature Nanotechnology: Huge study finds brain networks connected to teen drug abuse.  // Biomedical Market Newsletter;5/5/2012, Vol. 21, p1 

    The article reports that the Engineers at Brown University in Providence, Rhode Island and QD Vision Inc. have invented a nanoscale single crystal that could produce red, green, and blue laser lights which are used in digital displays.

  • Submicrometer resolution far field high sensitivity Kerr microscopy for in-plane magnetization detection. Wang, C. H.; Yang, Z. // Review of Scientific Instruments;Jul2009, Vol. 80 Issue 7, p073107 

    We report that a far field magneto-optical system designed for detecting the off-plane magnetization in polar configuration can also detect the in-plane magnetization, while preserving the high sensitivity by using symmetric illumination and photoelastic modulation, even though the optical axis...

  • A correlation force spectrometer for single molecule measurements under tensile load. Radiom, Milad; Honig, Christopher D. F.; Walz, John Y.; Paul, Mark R.; Ducker, William A. // Journal of Applied Physics;Jan2013, Vol. 113 Issue 1, p013503 

    The dynamical-mechanical properties of a small region of fluid can be measured using two closely spaced thermally stimulated micrometer-scale cantilevers. We call this technique correlation force spectroscopy (CFS). We describe an instrument that is designed for characterizing the extensional...

  • Repairing nanoscale scratched grooves on polycrystalline ceramics using optical near-field assisted sputtering. Nomura, W.; Yatsui, T.; Yanase, Y.; Suzuki, K.; Fujita, M.; Kamata, A.; Naruse, M.; Ohtsu, M. // Applied Physics B: Lasers & Optics;Apr2010, Vol. 99 Issue 1/2, p75 

    We propose an optical near-field assisted sputtering method for repairing scratches on the surface of polycrystalline ceramics in a self-assembling manner. An Al2O3 source was sputtered on substrates with laser radiation of wavelength 473 nm. The average depth of the scratched grooves on...

  • Simultaneous imaging of the topography and dynamic properties of nanomechanical systems by optical beam deflection microscopy. Kosaka, P. M.; Tamayo, J.; Gil-Santos, E.; Mertens, J.; Pini, V.; Martínez, N. F.; Ahumada, O.; Calleja, M. // Journal of Applied Physics;Mar2011, Vol. 109 Issue 6, p064315 

    We present an optical microscopy technique based on the scanning of a laser beam across the surface of a sample and the measurement of the deflection of the reflected laser beam in two dimensions. The technique is intended for characterization of nanomechanical systems. It provides the height of...

  • Note: Particle adhesion and imaging of particle/surface breakage zone. Pettersson, Torbjörn; Utsel, Simon; Wågberg, Lars // Review of Scientific Instruments;Oct2012, Vol. 83 Issue 10, p106107 

    An AFM methodology to enable measurement of the adhesion of micrometre sized objects, having contact areas in the range of nanometre to micrometer, is reported. The method also enables imaging of the actual breakage zone on both the surface and the removed object to obtain further information...

  • Superhydrophobic coatings A review. Srivastava, Sankalp; Khanuja, Gagandeep // Paintindia;Mar2016, Vol. 66 Issue 3, p51 

    Wetting of a solid surface by a liquid plays an important role in several phenomena and applications. Wetting of rough surfaces has attracted great scientific interest in recent decades. Superhydrophobic surfaces, which possess extraordinary water repelling properties due to their low surface...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics